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Items: 1 to 20 of 91

1.

Direct inhibition of the NOTCH transcription factor complex.

Moellering RE, Cornejo M, Davis TN, Del Bianco C, Aster JC, Blacklow SC, Kung AL, Gilliland DG, Verdine GL, Bradner JE.

Nature. 2009 Nov 12;462(7270):182-8. doi: 10.1038/nature08543. Erratum in: Nature. 2010 Jan 21;463(7279):384.

2.

Chemical biology: A Notch above other inhibitors.

Arora PS, Ansari AZ.

Nature. 2009 Nov 12;462(7270):171-3. doi: 10.1038/462171a. No abstract available.

PMID:
19907487
3.

Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia.

Yashiro-Ohtani Y, Wang H, Zang C, Arnett KL, Bailis W, Ho Y, Knoechel B, Lanauze C, Louis L, Forsyth KS, Chen S, Chung Y, Schug J, Blobel GA, Liebhaber SA, Bernstein BE, Blacklow SC, Liu XS, Aster JC, Pear WS.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):E4946-53. doi: 10.1073/pnas.1407079111. Epub 2014 Nov 4.

4.

DDX5 is a positive regulator of oncogenic NOTCH1 signaling in T cell acute lymphoblastic leukemia.

Lin S, Tian L, Shen H, Gu Y, Li JL, Chen Z, Sun X, You MJ, Wu L.

Oncogene. 2013 Oct;32(40):4845-53. doi: 10.1038/onc.2012.482. Epub 2012 Oct 29.

5.

Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors.

Aste-Am├ęzaga M, Zhang N, Lineberger JE, Arnold BA, Toner TJ, Gu M, Huang L, Vitelli S, Vo KT, Haytko P, Zhao JZ, Baleydier F, L'Heureux S, Wang H, Gordon WR, Thoryk E, Andrawes MB, Tiyanont K, Stegmaier K, Roti G, Ross KN, Franlin LL, Wang H, Wang F, Chastain M, Bett AJ, Audoly LP, Aster JC, Blacklow SC, Huber HE.

PLoS One. 2010 Feb 8;5(2):e9094. doi: 10.1371/journal.pone.0009094.

6.

FHL1C induces apoptosis in Notch1-dependent T-ALL cells through an interaction with RBP-J.

Fu W, Wang K, Zhao JL, Yu HC, Li SZ, Lin Y, Liang L, Huang SY, Liang YM, Han H, Qin HY.

BMC Cancer. 2014 Jun 22;14:463. doi: 10.1186/1471-2407-14-463.

7.

The Notch driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia.

Durinck K, Wallaert A, Van de Walle I, Van Loocke W, Volders PJ, Vanhauwaert S, Geerdens E, Benoit Y, Van Roy N, Poppe B, Soulier J, Cools J, Mestdagh P, Vandesompele J, Rondou P, Van Vlierberghe P, Taghon T, Speleman F.

Haematologica. 2014 Dec;99(12):1808-16. doi: 10.3324/haematol.2014.115683. Epub 2014 Oct 24.

8.

Notch dimerization is required for leukemogenesis and T-cell development.

Liu H, Chi AW, Arnett KL, Chiang MY, Xu L, Shestova O, Wang H, Li YM, Bhandoola A, Aster JC, Blacklow SC, Pear WS.

Genes Dev. 2010 Nov 1;24(21):2395-407. doi: 10.1101/gad.1975210. Epub 2010 Oct 8.

9.

RUNX3 directly interacts with intracellular domain of Notch1 and suppresses Notch signaling in hepatocellular carcinoma cells.

Gao J, Chen Y, Wu KC, Liu J, Zhao YQ, Pan YL, Du R, Zheng GR, Xiong YM, Xu HL, Fan DM.

Exp Cell Res. 2010 Jan 15;316(2):149-57. doi: 10.1016/j.yexcr.2009.09.025. Epub 2009 Oct 2.

PMID:
19800882
10.

Snail inhibits Notch1 intracellular domain mediated transcriptional activation via competing with MAML1.

Kim HS, Jeong H, Lim SO, Jung G.

Biochem Biophys Res Commun. 2013 Mar 29;433(1):6-10. doi: 10.1016/j.bbrc.2013.02.079. Epub 2013 Feb 27.

PMID:
23454378
11.

Notch ankyrin repeat domain variation influences leukemogenesis and Myc transactivation.

Aster JC, Bodnar N, Xu L, Karnell F, Milholland JM, Maillard I, Histen G, Nam Y, Blacklow SC, Pear WS.

PLoS One. 2011;6(10):e25645. doi: 10.1371/journal.pone.0025645. Epub 2011 Oct 13.

12.

Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling.

Weng AP, Nam Y, Wolfe MS, Pear WS, Griffin JD, Blacklow SC, Aster JC.

Mol Cell Biol. 2003 Jan;23(2):655-64.

13.

Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes.

Arnett KL, Hass M, McArthur DG, Ilagan MX, Aster JC, Kopan R, Blacklow SC.

Nat Struct Mol Biol. 2010 Nov;17(11):1312-7. doi: 10.1038/nsmb.1938. Epub 2010 Oct 24.

14.

Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.

Nam Y, Sliz P, Song L, Aster JC, Blacklow SC.

Cell. 2006 Mar 10;124(5):973-83.

15.

Proteasome inhibitors exert cytotoxicity and increase chemosensitivity via transcriptional repression of Notch1 in T-cell acute lymphoblastic leukemia.

Koyama D, Kikuchi J, Hiraoka N, Wada T, Kurosawa H, Chiba S, Furukawa Y.

Leukemia. 2014 Jun;28(6):1216-26. doi: 10.1038/leu.2013.366. Epub 2013 Dec 4.

16.

NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.

Yatim A, Benne C, Sobhian B, Laurent-Chabalier S, Deas O, Judde JG, Lelievre JD, Levy Y, Benkirane M.

Mol Cell. 2012 Nov 9;48(3):445-58. doi: 10.1016/j.molcel.2012.08.022. Epub 2012 Sep 27.

17.
18.

Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL.

Jeannet R, Mastio J, Macias-Garcia A, Oravecz A, Ashworth T, Geimer Le Lay AS, Jost B, Le Gras S, Ghysdael J, Gridley T, Honjo T, Radtke F, Aster JC, Chan S, Kastner P.

Blood. 2010 Dec 16;116(25):5443-54. doi: 10.1182/blood-2010-05-286658. Epub 2010 Sep 9.

19.

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