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Items: 1 to 20 of 93

1.

Discovery and validation of a series of aryl sulfonamides as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP).

Dahl R, Sergienko EA, Su Y, Mostofi YS, Yang L, Simao AM, Narisawa S, Brown B, Mangravita-Novo A, Vicchiarelli M, Smith LH, O'Neill WC, Millán JL, Cosford ND.

J Med Chem. 2009 Nov 12;52(21):6919-25. doi: 10.1021/jm900383s.

2.

Design and synthesis of pyrazole derivatives as potent and selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP).

Sidique S, Ardecky R, Su Y, Narisawa S, Brown B, Millán JL, Sergienko E, Cosford ND.

Bioorg Med Chem Lett. 2009 Jan 1;19(1):222-5. doi: 10.1016/j.bmcl.2008.10.107. Epub 2008 Oct 31.

3.

Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor.

Pinkerton AB, Sergienko E, Bravo Y, Dahl R, Ma CT, Sun Q, Jackson MR, Cosford NDP, Millán JL.

Bioorg Med Chem Lett. 2018 Jan 1;28(1):31-34. doi: 10.1016/j.bmcl.2017.11.024. Epub 2017 Nov 11.

PMID:
29174347
4.

Identification and characterization of novel tissue-nonspecific alkaline phosphatase inhibitors with diverse modes of action.

Sergienko E, Su Y, Chan X, Brown B, Hurder A, Narisawa S, Millán JL.

J Biomol Screen. 2009 Aug;14(7):824-37. doi: 10.1177/1087057109338517. Epub 2009 Jun 25.

5.

Diarylsulfonamides and their bioisosteres as dual inhibitors of alkaline phosphatase and carbonic anhydrase: Structure activity relationship and molecular modelling studies.

Al-Rashida M, Ejaz SA, Ali S, Shaukat A, Hamayoun M, Ahmed M, Iqbal J.

Bioorg Med Chem. 2015 May 15;23(10):2435-44. doi: 10.1016/j.bmc.2015.03.054. Epub 2015 Mar 27.

PMID:
25865133
6.

Facile dimethyl amino group triggered cyclic sulfonamides synthesis and evaluation as alkaline phosphatase inhibitors.

Bhatti HA, Khatoon M, Al-Rashida M, Bano H, Iqbal N, Zaib-Un-Nisa, Yousuf S, Khan KM, Hameed A, Iqbal J.

Bioorg Chem. 2017 Apr;71:10-18. doi: 10.1016/j.bioorg.2017.01.008. Epub 2017 Jan 18.

PMID:
28139246
7.

Inhibitors of tissue-nonspecific alkaline phosphatase: design, synthesis, kinetics, biomineralization and cellular tests.

Debray J, Chang L, Marquès S, Pellet-Rostaing S, Le Duy D, Mebarek S, Buchet R, Magne D, Popowycz F, Lemaire M.

Bioorg Med Chem. 2013 Dec 15;21(24):7981-7. doi: 10.1016/j.bmc.2013.09.053. Epub 2013 Oct 17.

PMID:
24183741
8.

Synthesis, characterization and biological evaluation of novel chalcone sulfonamide hybrids as potent intestinal alkaline phosphatase inhibitors.

Ejaz SA, Saeed A, Siddique MN, Nisa ZU, Khan S, Lecka J, Sévigny J, Iqbal J.

Bioorg Chem. 2017 Feb;70:229-236. doi: 10.1016/j.bioorg.2017.01.003. Epub 2017 Jan 5.

PMID:
28110961
9.

Synthesis of benzofuran derivatives as selective inhibitors of tissue-nonspecific alkaline phosphatase: effects on cell toxicity and osteoblast-induced mineralization.

Marquès S, Buchet R, Popowycz F, Lemaire M, Mebarek S.

Bioorg Med Chem Lett. 2016 Mar 1;26(5):1457-9. doi: 10.1016/j.bmcl.2016.01.061. Epub 2016 Jan 22.

PMID:
26860736
10.

A method for direct assessment of tissue-nonspecific alkaline phosphatase (TNAP) inhibitors in blood samples.

Sergienko EA, Sun Q, Ma CT.

Methods Mol Biol. 2013;1053:103-13. doi: 10.1007/978-1-62703-562-0_6.

PMID:
23860649
11.

Modulators of intestinal alkaline phosphatase.

Bobkova EV, Kiffer-Moreira T, Sergienko EA.

Methods Mol Biol. 2013;1053:135-44. doi: 10.1007/978-1-62703-562-0_9.

PMID:
23860652
12.
13.

Inhibitors of tissue-nonspecific alkaline phosphatase (TNAP): from hits to leads.

Teriete P, Pinkerton AB, Cosford ND.

Methods Mol Biol. 2013;1053:85-101. doi: 10.1007/978-1-62703-562-0_5.

PMID:
23860648
14.

Identification of novel chromone based sulfonamides as highly potent and selective inhibitors of alkaline phosphatases.

al-Rashida M, Raza R, Abbas G, Shah MS, Kostakis GE, Lecka J, Sévigny J, Muddassar M, Papatriantafyllopoulou C, Iqbal J.

Eur J Med Chem. 2013 Aug;66:438-49. doi: 10.1016/j.ejmech.2013.06.015. Epub 2013 Jun 19.

PMID:
23831808
15.

High-throughput screening of tissue-nonspecific alkaline phosphatase for identification of effectors with diverse modes of action.

Sergienko EA, Millán JL.

Nat Protoc. 2010 Aug;5(8):1431-9. doi: 10.1038/nprot.2010.86. Epub 2010 Jul 15.

16.

Identification of a selective inhibitor of murine intestinal alkaline phosphatase (ML260) by concurrent ultra-high throughput screening against human and mouse isozymes.

Ardecky RJ, Bobkova EV, Kiffer-Moreira T, Brown B, Ganji S, Zou J, Pass I, Narisawa S, Iano FG, Rosenstein C, Cheltsov A, Rascon J, Hedrick M, Gasior C, Forster A, Shi S, Dahl R, Vasile S, Su Y, Sergienko E, Chung TDY, Kaunitz J, Hoylaerts MF, Pinkerton AB, Millán JL.

Bioorg Med Chem Lett. 2014 Feb 1;24(3):1000-1004. doi: 10.1016/j.bmcl.2013.12.043. Epub 2013 Dec 19.

17.

Upregulation of alkaline phosphatase and pyrophosphate hydrolysis: potential mechanism for uremic vascular calcification.

Lomashvili KA, Garg P, Narisawa S, Millan JL, O'Neill WC.

Kidney Int. 2008 May;73(9):1024-30. doi: 10.1038/ki.2008.26. Epub 2008 Feb 20.

18.

Discovery of a novel series of potent and orally bioavailable phosphoinositide 3-kinase γ inhibitors.

Leahy JW, Buhr CA, Johnson HW, Kim BG, Baik T, Cannoy J, Forsyth TP, Jeong JW, Lee MS, Ma S, Noson K, Wang L, Williams M, Nuss JM, Brooks E, Foster P, Goon L, Heald N, Holst C, Jaeger C, Lam S, Lougheed J, Nguyen L, Plonowski A, Song J, Stout T, Wu X, Yakes MF, Yu P, Zhang W, Lamb P, Raeber O.

J Med Chem. 2012 Jun 14;55(11):5467-82. doi: 10.1021/jm300403a. Epub 2012 May 17.

PMID:
22548342
19.

Novel inhibitors of alkaline phosphatase suppress vascular smooth muscle cell calcification.

Narisawa S, Harmey D, Yadav MC, O'Neill WC, Hoylaerts MF, Millán JL.

J Bone Miner Res. 2007 Nov;22(11):1700-10.

20.

Efficacy, pharmacokinetics, and metabolism of tetrahydroquinoline inhibitors of Plasmodium falciparum protein farnesyltransferase.

Van Voorhis WC, Rivas KL, Bendale P, Nallan L, Hornéy C, Barrett LK, Bauer KD, Smart BP, Ankala S, Hucke O, Verlinde CL, Chakrabarti D, Strickland C, Yokoyama K, Buckner FS, Hamilton AD, Williams DK, Lombardo LJ, Floyd D, Gelb MH.

Antimicrob Agents Chemother. 2007 Oct;51(10):3659-71. Epub 2007 Jul 2.

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