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Items: 1 to 20 of 93


Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model.

Bric A, Miething C, Bialucha CU, Scuoppo C, Zender L, Krasnitz A, Xuan Z, Zuber J, Wigler M, Hicks J, McCombie RW, Hemann MT, Hannon GJ, Powers S, Lowe SW.

Cancer Cell. 2009 Oct 6;16(4):324-35. doi: 10.1016/j.ccr.2009.08.015.


An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo.

Hemann MT, Fridman JS, Zilfou JT, Hernando E, Paddison PJ, Cordon-Cardo C, Hannon GJ, Lowe SW.

Nat Genet. 2003 Mar;33(3):396-400. Epub 2003 Feb 3.


Deletion of Irf5 protects hematopoietic stem cells from DNA damage-induced apoptosis and suppresses γ-irradiation-induced thymic lymphomagenesis.

Bi X, Feng D, Korczeniewska J, Alper N, Hu G, Barnes BJ.

Oncogene. 2014 Jun 19;33(25):3288-97. doi: 10.1038/onc.2013.295. Epub 2013 Aug 5.


Suppression of tumorigenesis by the p53 target PUMA.

Hemann MT, Zilfou JT, Zhao Z, Burgess DJ, Hannon GJ, Lowe SW.

Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9333-8. Epub 2004 Jun 10.


FoxOs in tumor suppression and stem cell maintenance.

Arden KC.

Cell. 2007 Jan 26;128(2):235-7. Review.


Down-regulation of SFRP1 as a putative tumor suppressor gene can contribute to human hepatocellular carcinoma.

Huang J, Zhang YL, Teng XM, Lin Y, Zheng DL, Yang PY, Han ZG.

BMC Cancer. 2007 Jul 12;7:126.


Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors.

Horton SJ, Giotopoulos G, Yun H, Vohra S, Sheppard O, Bashford-Rogers R, Rashid M, Clipson A, Chan WI, Sasca D, Yiangou L, Osaki H, Basheer F, Gallipoli P, Burrows N, Erdem A, Sybirna A, Foerster S, Zhao W, Sustic T, Petrunkina Harrison A, Laurenti E, Okosun J, Hodson D, Wright P, Smith KG, Maxwell P, Fitzgibbon J, Du MQ, Adams DJ, Huntly BJP.

Nat Cell Biol. 2017 Sep;19(9):1093-1104. doi: 10.1038/ncb3597. Epub 2017 Aug 21.


Phosphorylation of p53 serine 18 upregulates apoptosis to suppress Myc-induced tumorigenesis.

Sluss HK, Gannon H, Coles AH, Shen Q, Eischen CM, Jones SN.

Mol Cancer Res. 2010 Feb;8(2):216-22. doi: 10.1158/1541-7786.MCR-09-0324. Epub 2010 Feb 9.


Myc-mediated proliferation and lymphomagenesis, but not apoptosis, are compromised by E2f1 loss.

Baudino TA, Maclean KH, Brennan J, Parganas E, Yang C, Aslanian A, Lees JA, Sherr CJ, Roussel MF, Cleveland JL.

Mol Cell. 2003 Apr;11(4):905-14.


Dosage-dependent tumor suppression by histone deacetylases 1 and 2 through regulation of c-Myc collaborating genes and p53 function.

Heideman MR, Wilting RH, Yanover E, Velds A, de Jong J, Kerkhoven RM, Jacobs H, Wessels LF, Dannenberg JH.

Blood. 2013 Mar 14;121(11):2038-50. doi: 10.1182/blood-2012-08-450916. Epub 2013 Jan 17.


miR-146a enhances the oncogenicity of oral carcinoma by concomitant targeting of the IRAK1, TRAF6 and NUMB genes.

Hung PS, Liu CJ, Chou CS, Kao SY, Yang CC, Chang KW, Chiu TH, Lin SC.

PLoS One. 2013 Nov 26;8(11):e79926. doi: 10.1371/journal.pone.0079926. eCollection 2013.


Oncogene-induced senescence as an initial barrier in lymphoma development.

Braig M, Lee S, Loddenkemper C, Rudolph C, Peters AH, Schlegelberger B, Stein H, Dörken B, Jenuwein T, Schmitt CA.

Nature. 2005 Aug 4;436(7051):660-5.


Dissecting p53 tumor suppressor functions in vivo.

Schmitt CA, Fridman JS, Yang M, Baranov E, Hoffman RM, Lowe SW.

Cancer Cell. 2002 Apr;1(3):289-98.


Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance.

Campbell KJ, Bath ML, Turner ML, Vandenberg CJ, Bouillet P, Metcalf D, Scott CL, Cory S.

Blood. 2010 Oct 28;116(17):3197-207. doi: 10.1182/blood-2010-04-281071. Epub 2010 Jul 14.


Absence of manganese superoxide dismutase delays p53-induced tumor formation.

Case AJ, Domann FE.

Redox Biol. 2014 Jan 13;2:220-3. doi: 10.1016/j.redox.2014.01.001. eCollection 2014.


DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation.

Raveh T, Droguett G, Horwitz MS, DePinho RA, Kimchi A.

Nat Cell Biol. 2001 Jan;3(1):1-7.


Multiple tumor suppressor pathways negatively regulate telomerase.

Lin SY, Elledge SJ.

Cell. 2003 Jun 27;113(7):881-9.


Hipk2 cooperates with p53 to suppress γ-ray radiation-induced mouse thymic lymphoma.

Mao JH, Wu D, Kim IJ, Kang HC, Wei G, Climent J, Kumar A, Pelorosso FG, DelRosario R, Huang EJ, Balmain A.

Oncogene. 2012 Mar 1;31(9):1176-80. doi: 10.1038/onc.2011.306. Epub 2011 Jul 25.


A functional genomics approach for the identification of putative tumor suppressor genes: Dickkopf-1 as suppressor of HeLa cell transformation.

Mikheev AM, Mikheeva SA, Liu B, Cohen P, Zarbl H.

Carcinogenesis. 2004 Jan;25(1):47-59. Epub 2003 Oct 10.


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