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Items: 1 to 20 of 135

1.

Recognition of Borrelia burgdorferi, the Lyme disease spirochete, by TLR7 and TLR9 induces a type I IFN response by human immune cells.

Petzke MM, Brooks A, Krupna MA, Mordue D, Schwartz I.

J Immunol. 2009 Oct 15;183(8):5279-92. doi: 10.4049/jimmunol.0901390. Epub 2009 Sep 30.

2.

Borrelia burgdorferi RNA induces type I and III interferons via Toll-like receptor 7 and contributes to production of NF-κB-dependent cytokines.

Love AC, Schwartz I, Petzke MM.

Infect Immun. 2014 Jun;82(6):2405-16. doi: 10.1128/IAI.01617-14. Epub 2014 Mar 24.

3.

Induction of indoleamine 2,3-dioxygenase by Borrelia burgdorferi in human immune cells correlates with pathogenic potential.

Love AC, Schwartz I, Petzke MM.

J Leukoc Biol. 2015 Feb;97(2):379-90. doi: 10.1189/jlb.4A0714-339R. Epub 2014 Nov 24.

4.

Bruton's tyrosine kinase regulates TLR9 but not TLR7 signaling in human plasmacytoid dendritic cells.

Wang J, Lau KY, Jung J, Ravindran P, Barrat FJ.

Eur J Immunol. 2014 Apr;44(4):1130-6. doi: 10.1002/eji.201344030. Epub 2014 Jan 20.

5.

The Lyme disease spirochete Borrelia burgdorferi utilizes multiple ligands, including RNA, for interferon regulatory factor 3-dependent induction of type I interferon-responsive genes.

Miller JC, Maylor-Hagen H, Ma Y, Weis JH, Weis JJ.

Infect Immun. 2010 Jul;78(7):3144-53. doi: 10.1128/IAI.01070-09. Epub 2010 Apr 19.

6.

Toll-like receptor 7 and 9 defects in common variable immunodeficiency.

Yu JE, Knight AK, Radigan L, Marron TU, Zhang L, Sanchez-Ramón S, Cunningham-Rundles C.

J Allergy Clin Immunol. 2009 Aug;124(2):349-56, 356.e1-3. doi: 10.1016/j.jaci.2009.05.019. Epub 2009 Jul 9.

7.

A critical role for type I IFN in arthritis development following Borrelia burgdorferi infection of mice.

Miller JC, Ma Y, Bian J, Sheehan KC, Zachary JF, Weis JH, Schreiber RD, Weis JJ.

J Immunol. 2008 Dec 15;181(12):8492-503.

8.

Downregulation of TLR7/9 leads to deficient production of IFN-α from plasmacytoid dendritic cells in chronic hepatitis B.

Xu N, Yao HP, Lv GC, Chen Z.

Inflamm Res. 2012 Sep;61(9):997-1004. doi: 10.1007/s00011-012-0493-z. Epub 2012 Jun 10.

PMID:
22684144
9.

Human TLR8 is activated upon recognition of Borrelia burgdorferi RNA in the phagosome of human monocytes.

Cervantes JL, La Vake CJ, Weinerman B, Luu S, O'Connell C, Verardi PH, Salazar JC.

J Leukoc Biol. 2013 Dec;94(6):1231-41. doi: 10.1189/jlb.0413206. Epub 2013 Aug 1.

10.

In vitro immunomodulatory activity of interferon alpha on toll-like receptor 9 signaling pathway in chronic hepatitis B.

Wang X, Zhao YR, Liu HL, Ma XH, Zhang Y.

J Interferon Cytokine Res. 2015 May;35(5):385-91. doi: 10.1089/jir.2014.0182. Epub 2014 Dec 23.

PMID:
25535670
11.

Borrelia burgdorferi arthritis-associated locus Bbaa1 regulates Lyme arthritis and K/B×N serum transfer arthritis through intrinsic control of type I IFN production.

Ma Y, Bramwell KK, Lochhead RB, Paquette JK, Zachary JF, Weis JH, Teuscher C, Weis JJ.

J Immunol. 2014 Dec 15;193(12):6050-60. doi: 10.4049/jimmunol.1401746. Epub 2014 Nov 5.

12.

Phagosomal signaling by Borrelia burgdorferi in human monocytes involves Toll-like receptor (TLR) 2 and TLR8 cooperativity and TLR8-mediated induction of IFN-beta.

Cervantes JL, Dunham-Ems SM, La Vake CJ, Petzke MM, Sahay B, Sellati TJ, Radolf JD, Salazar JC.

Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3683-8. doi: 10.1073/pnas.1013776108. Epub 2011 Feb 14.

13.

Negative regulation of TLR9-mediated IFN-alpha induction by a small-molecule, synthetic TLR7 ligand.

Marshall JD, Heeke DS, Gesner ML, Livingston B, Van Nest G.

J Leukoc Biol. 2007 Sep;82(3):497-508. Epub 2007 Jun 12.

PMID:
17565046
14.

Selective control of type I IFN induction by the Rac activator DOCK2 during TLR-mediated plasmacytoid dendritic cell activation.

Gotoh K, Tanaka Y, Nishikimi A, Nakamura R, Yamada H, Maeda N, Ishikawa T, Hoshino K, Uruno T, Cao Q, Higashi S, Kawaguchi Y, Enjoji M, Takayanagi R, Kaisho T, Yoshikai Y, Fukui Y.

J Exp Med. 2010 Apr 12;207(4):721-30. doi: 10.1084/jem.20091776. Epub 2010 Mar 15.

15.

TRIM35 negatively regulates TLR7- and TLR9-mediated type I interferon production by targeting IRF7.

Wang Y, Yan S, Yang B, Wang Y, Zhou H, Lian Q, Sun B.

FEBS Lett. 2015 May 22;589(12):1322-30. doi: 10.1016/j.febslet.2015.04.019. Epub 2015 Apr 20.

16.

Borrelia burgdorferi induces a type I interferon response during early stages of disseminated infection in mice.

Petzke MM, Iyer R, Love AC, Spieler Z, Brooks A, Schwartz I.

BMC Microbiol. 2016 Mar 8;16:29. doi: 10.1186/s12866-016-0644-4.

17.

Guanine-modified inhibitory oligonucleotides efficiently impair TLR7- and TLR9-mediated immune responses of human immune cells.

Römmler F, Hammel M, Waldhuber A, Müller T, Jurk M, Uhlmann E, Wagner H, Vollmer J, Miethke T.

PLoS One. 2015 Feb 19;10(2):e0116703. doi: 10.1371/journal.pone.0116703. eCollection 2015.

18.

TLR7 agonist 852A inhibition of tumor cell proliferation is dependent on plasmacytoid dendritic cells and type I IFN.

Inglefield JR, Dumitru CD, Alkan SS, Gibson SJ, Lipson KE, Tomai MA, Larson CJ, Vasilakos JP.

J Interferon Cytokine Res. 2008 Apr;28(4):253-63. doi: 10.1089/jir.2007.0097.

PMID:
18439103
19.

Human Metapneumovirus M2-2 Protein Acts as a Negative Regulator of Alpha Interferon Production by Plasmacytoid Dendritic Cells.

Kitagawa Y, Sakai M, Funayama M, Itoh M, Gotoh B.

J Virol. 2017 Sep 27;91(20). pii: e00579-17. doi: 10.1128/JVI.00579-17. Print 2017 Oct 15.

20.

Blocking TLR7- and TLR9-mediated IFN-α production by plasmacytoid dendritic cells does not diminish immune activation in early SIV infection.

Kader M, Smith AP, Guiducci C, Wonderlich ER, Normolle D, Watkins SC, Barrat FJ, Barratt-Boyes SM.

PLoS Pathog. 2013;9(7):e1003530. doi: 10.1371/journal.ppat.1003530. Epub 2013 Jul 25.

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