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Items: 1 to 20 of 93


Reconstitution and engineering of apoptotic protein interactions on the bacterial cell surface.

Sun J, Abdeljabbar DM, Clarke N, Bellows ML, Floudas CA, Link AJ.

J Mol Biol. 2009 Nov 27;394(2):297-305. doi: 10.1016/j.jmb.2009.09.023. Epub 2009 Sep 17.


The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner.

Kazi A, Sun J, Doi K, Sung SS, Takahashi Y, Yin H, Rodriguez JM, Becerril J, Berndt N, Hamilton AD, Wang HG, Sebti SM.

J Biol Chem. 2011 Mar 18;286(11):9382-92. doi: 10.1074/jbc.M110.203638. Epub 2010 Dec 9.


Context-dependent Bcl-2/Bak interactions regulate lymphoid cell apoptosis.

Dai H, Meng XW, Lee SH, Schneider PA, Kaufmann SH.

J Biol Chem. 2009 Jul 3;284(27):18311-22. doi: 10.1074/jbc.M109.004770. Epub 2009 Apr 7.


Regulation of stress-induced nuclear protein redistribution: a new function of Bax and Bak uncoupled from Bcl-x(L).

Lindenboim L, Blacher E, Borner C, Stein R.

Cell Death Differ. 2010 Feb;17(2):346-59. doi: 10.1038/cdd.2009.145. Epub 2009 Oct 9.


p14(ARF)-induced apoptosis in p53 protein-deficient cells is mediated by BH3-only protein-independent derepression of Bak protein through down-regulation of Mcl-1 and Bcl-xL proteins.

Müer A, Overkamp T, Gillissen B, Richter A, Pretzsch T, Milojkovic A, Dörken B, Daniel PT, Hemmati P.

J Biol Chem. 2012 May 18;287(21):17343-52. doi: 10.1074/jbc.M111.314898. Epub 2012 Feb 21.


A comparison of two strategies for affinity maturation of a BH3 peptide toward pro-survival Bcl-2 proteins.

Zhang S, Long A, Link AJ.

ACS Synth Biol. 2012 Mar 16;1(3):89-98. doi: 10.1021/sb200002m. Epub 2011 Oct 7.


Differential regulation of Bax and Bak by anti-apoptotic Bcl-2 family proteins Bcl-B and Mcl-1.

Zhai D, Jin C, Huang Z, Satterthwait AC, Reed JC.

J Biol Chem. 2008 Apr 11;283(15):9580-6. doi: 10.1074/jbc.M708426200. Epub 2008 Jan 4.


Molecular basis for Bcl-2 homology 3 domain recognition in the Bcl-2 protein family: identification of conserved hot spot interactions.

Moroy G, Martin E, Dejaegere A, Stote RH.

J Biol Chem. 2009 Jun 26;284(26):17499-511. doi: 10.1074/jbc.M805542200. Epub 2009 Mar 17.


In non-transformed cells Bak activates upon loss of anti-apoptotic Bcl-XL and Mcl-1 but in the absence of active BH3-only proteins.

Senft D, Weber A, Saathoff F, Berking C, Heppt MV, Kammerbauer C, Rothenfusser S, Kellner S, Kurgyis Z, Besch R, Häcker G.

Cell Death Dis. 2015 Nov 26;6:e1996. doi: 10.1038/cddis.2015.341.


Comparative biophysical characterization of p53 with the pro-apoptotic BAK and the anti-apoptotic BCL-xL.

Sot B, Freund SM, Fersht AR.

J Biol Chem. 2007 Oct 5;282(40):29193-200. Epub 2007 Aug 14.


NBK/BIK antagonizes MCL-1 and BCL-XL and activates BAK-mediated apoptosis in response to protein synthesis inhibition.

Shimazu T, Degenhardt K, Nur-E-Kamal A, Zhang J, Yoshida T, Zhang Y, Mathew R, White E, Inouye M.

Genes Dev. 2007 Apr 15;21(8):929-41. Epub 2007 Apr 2.


Mutual regulation of Bcl-2 proteins independent of the BH3 domain as shown by the BH3-lacking protein Bcl-x(AK).

Plötz M, Hossini AM, Gillissen B, Daniel PT, Stockfleth E, Eberle J.

PLoS One. 2012;7(4):e34549. doi: 10.1371/journal.pone.0034549. Epub 2012 Apr 10.


Physiological restraint of Bak by Bcl-xL is essential for cell survival.

Lee EF, Grabow S, Chappaz S, Dewson G, Hockings C, Kluck RM, Debrincat MA, Gray DH, Witkowski MT, Evangelista M, Pettikiriarachchi A, Bouillet P, Lane RM, Czabotar PE, Colman PM, Smith BJ, Kile BT, Fairlie WD.

Genes Dev. 2016 May 15;30(10):1240-50. doi: 10.1101/gad.279414.116. Epub 2016 May 19.


BH3 domains other than Bim and Bid can directly activate Bax/Bak.

Du H, Wolf J, Schafer B, Moldoveanu T, Chipuk JE, Kuwana T.

J Biol Chem. 2011 Jan 7;286(1):491-501. doi: 10.1074/jbc.M110.167148. Epub 2010 Nov 1.


NMR solution structure of a photoswitchable apoptosis activating Bak peptide bound to Bcl-xL.

Wysoczanski P, Mart RJ, Loveridge EJ, Williams C, Whittaker SB, Crump MP, Allemann RK.

J Am Chem Soc. 2012 May 9;134(18):7644-7. doi: 10.1021/ja302390a. Epub 2012 Apr 25.


Disruption of the VDAC2-Bak interaction by Bcl-x(S) mediates efficient induction of apoptosis in melanoma cells.

Plötz M, Gillissen B, Hossini AM, Daniel PT, Eberle J.

Cell Death Differ. 2012 Dec;19(12):1928-38. doi: 10.1038/cdd.2012.71. Epub 2012 Jun 15.


Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies.

Kim H, Rafiuddin-Shah M, Tu HC, Jeffers JR, Zambetti GP, Hsieh JJ, Cheng EH.

Nat Cell Biol. 2006 Dec;8(12):1348-58. Epub 2006 Nov 19.


Caspase-mediated Bak activation and cytochrome c release during intrinsic apoptotic cell death in Jurkat cells.

Shawgo ME, Shelton SN, Robertson JD.

J Biol Chem. 2008 Dec 19;283(51):35532-8. doi: 10.1074/jbc.M807656200. Epub 2008 Oct 15.

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