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Items: 1 to 20 of 122

1.

XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy.

Hetz C, Thielen P, Matus S, Nassif M, Court F, Kiffin R, Martinez G, Cuervo AM, Brown RH, Glimcher LH.

Genes Dev. 2009 Oct 1;23(19):2294-306. doi: 10.1101/gad.1830709. Epub 2009 Sep 17.

2.

XBP-1 deficiency in the nervous system reveals a homeostatic switch to activate autophagy.

Matus S, Nassif M, Glimcher LH, Hetz C.

Autophagy. 2009 Nov;5(8):1226-8. Epub 2009 Nov 6.

PMID:
19855189
3.

The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS).

Crippa V, Sau D, Rusmini P, Boncoraglio A, Onesto E, Bolzoni E, Galbiati M, Fontana E, Marino M, Carra S, Bendotti C, De Biasi S, Poletti A.

Hum Mol Genet. 2010 Sep 1;19(17):3440-56. doi: 10.1093/hmg/ddq257. Epub 2010 Jun 22.

PMID:
20570967
4.

Autophagy for the avoidance of neurodegeneration.

Madeo F, Eisenberg T, Kroemer G.

Genes Dev. 2009 Oct 1;23(19):2253-9. doi: 10.1101/gad.1858009.

5.

Altered macroautophagy in the spinal cord of SOD1 mutant mice.

Li L, Zhang X, Le W.

Autophagy. 2008 Apr;4(3):290-3. Epub 2008 Jan 7.

PMID:
18196963
6.

Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons.

Castillo K, Nassif M, Valenzuela V, Rojas F, Matus S, Mercado G, Court FA, van Zundert B, Hetz C.

Autophagy. 2013 Sep;9(9):1308-20. doi: 10.4161/auto.25188. Epub 2013 Jun 6.

PMID:
23851366
7.

SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system.

Watanabe S, Ageta-Ishihara N, Nagatsu S, Takao K, Komine O, Endo F, Miyakawa T, Misawa H, Takahashi R, Kinoshita M, Yamanaka K.

Mol Brain. 2014 Aug 29;7:62. doi: 10.1186/s13041-014-0062-1.

8.

ER stress and UPR in familial amyotrophic lateral sclerosis.

Turner BJ, Atkin JD.

Curr Mol Med. 2006 Feb;6(1):79-86.

PMID:
16472115
9.

The role of heat shock proteins in Amyotrophic Lateral Sclerosis: The therapeutic potential of Arimoclomol.

Kalmar B, Lu CH, Greensmith L.

Pharmacol Ther. 2014 Jan;141(1):40-54. doi: 10.1016/j.pharmthera.2013.08.003. Epub 2013 Aug 23. Review.

PMID:
23978556
10.

Superoxide dismutase 1 mutants related to amyotrophic lateral sclerosis induce endoplasmic stress in neuro2a cells.

Oh YK, Shin KS, Yuan J, Kang SJ.

J Neurochem. 2008 Feb;104(4):993-1005. doi: 10.1111/j.1471-4159.2007.05053.x.

11.

Stress signaling from the endoplasmic reticulum: A central player in the pathogenesis of amyotrophic lateral sclerosis.

Walker AK, Atkin JD.

IUBMB Life. 2011 Sep;63(9):754-63. doi: 10.1002/iub.520. Epub 2011 Aug 10. Review.

12.

Protein disulphide isomerase protects against protein aggregation and is S-nitrosylated in amyotrophic lateral sclerosis.

Walker AK, Farg MA, Bye CR, McLean CA, Horne MK, Atkin JD.

Brain. 2010 Jan;133(Pt 1):105-16. doi: 10.1093/brain/awp267. Epub 2009 Nov 10.

PMID:
19903735
13.

Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy.

Vidal RL, Figueroa A, Court FA, Thielen P, Molina C, Wirth C, Caballero B, Kiffin R, Segura-Aguilar J, Cuervo AM, Glimcher LH, Hetz C.

Hum Mol Genet. 2012 May 15;21(10):2245-62. doi: 10.1093/hmg/dds040. Epub 2012 Feb 14.

14.

Derlin-1 overexpression ameliorates mutant SOD1-induced endoplasmic reticulum stress by reducing mutant SOD1 accumulation.

Mori A, Yamashita S, Uchino K, Suga T, Ikeda T, Takamatsu K, Ishizaki M, Koide T, Kimura E, Mita S, Maeda Y, Hirano T, Uchino M.

Neurochem Int. 2011 Feb;58(3):344-53. doi: 10.1016/j.neuint.2010.12.010. Epub 2010 Dec 23.

PMID:
21185345
15.

Histological evidence of protein aggregation in mutant SOD1 transgenic mice and in amyotrophic lateral sclerosis neural tissues.

Watanabe M, Dykes-Hoberg M, Culotta VC, Price DL, Wong PC, Rothstein JD.

Neurobiol Dis. 2001 Dec;8(6):933-41.

PMID:
11741389
17.
18.

MST1 functions as a key modulator of neurodegeneration in a mouse model of ALS.

Lee JK, Shin JH, Hwang SG, Gwag BJ, McKee AC, Lee J, Kowall NW, Ryu H, Lim DS, Choi EJ.

Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):12066-71. doi: 10.1073/pnas.1300894110. Epub 2013 Jul 1.

19.
20.

Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis.

Nassif M, Valenzuela V, Rojas-Rivera D, Vidal R, Matus S, Castillo K, Fuentealba Y, Kroemer G, Levine B, Hetz C.

Autophagy. 2014 Jul;10(7):1256-71. doi: 10.4161/auto.28784. Epub 2014 May 12.

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