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Items: 1 to 20 of 86

1.

GIGYF2 gene disruption in mice results in neurodegeneration and altered insulin-like growth factor signaling.

Giovannone B, Tsiaras WG, de la Monte S, Klysik J, Lautier C, Karashchuk G, Goldwurm S, Smith RJ.

Hum Mol Genet. 2009 Dec 1;18(23):4629-39. doi: 10.1093/hmg/ddp430. Epub 2009 Sep 10.

2.

GIGYF2 is present in endosomal compartments in the mammalian brains and enhances IGF-1-induced ERK1/2 activation.

Higashi S, Iseki E, Minegishi M, Togo T, Kabuta T, Wada K.

J Neurochem. 2010 Oct;115(2):423-37. doi: 10.1111/j.1471-4159.2010.06930.x. Epub 2010 Aug 25.

3.

Negative regulation of Grb10 Interacting GYF Protein 2 on insulin-like growth factor-1 receptor signaling pathway caused diabetic mice cognitive impairment.

Xie J, Wei Q, Deng H, Li G, Ma L, Zeng H.

PLoS One. 2014 Sep 30;9(9):e108559. doi: 10.1371/journal.pone.0108559. eCollection 2014.

4.

Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling.

Giovannone B, Lee E, Laviola L, Giorgino F, Cleveland KA, Smith RJ.

J Biol Chem. 2003 Aug 22;278(34):31564-73. Epub 2003 May 27.

5.

Insulin receptor (IR) pathway hyperactivity in IGF-IR null cells and suppression of downstream growth signaling using the dual IGF-IR/IR inhibitor, BMS-754807.

Dinchuk JE, Cao C, Huang F, Reeves KA, Wang J, Myers F, Cantor GH, Zhou X, Attar RM, Gottardis M, Carboni JM.

Endocrinology. 2010 Sep;151(9):4123-32. doi: 10.1210/en.2010-0032. Epub 2010 Jul 7.

PMID:
20610571
6.

GIGYF2 mutations are not a frequent cause of familial Parkinson's disease.

Di Fonzo A, Fabrizio E, Thomas A, Fincati E, Marconi R, Tinazzi M, Breedveld GJ, Simons EJ, Chien HF, Ferreira JJ, Horstink MW, Abbruzzese G, Borroni B, Cossu G, Dalla Libera A, Fabbrini G, Guidi M, De Mari M, Lopiano L, Martignoni E, Marini P, Onofrj M, Padovani A, Stocchi F, Toni V, Sampaio C, Barbosa ER, Meco G; Italian Parkinson Genetics Network, Oostra BA, Bonifati V.

Parkinsonism Relat Disord. 2009 Nov;15(9):703-5. doi: 10.1016/j.parkreldis.2009.05.001. Epub 2009 May 31.

PMID:
19482505
7.

The insulin-like growth factor type 1 and insulin-like growth factor type 2/mannose-6-phosphate receptors independently regulate ERK1/2 activity in HEK293 cells.

El-Shewy HM, Lee MH, Obeid LM, Jaffa AA, Luttrell LM.

J Biol Chem. 2007 Sep 7;282(36):26150-7. Epub 2007 Jul 9.

8.

Mutations in the GIGYF2 (TNRC15) gene at the PARK11 locus in familial Parkinson disease.

Lautier C, Goldwurm S, Dürr A, Giovannone B, Tsiaras WG, Pezzoli G, Brice A, Smith RJ.

Am J Hum Genet. 2008 Apr;82(4):822-33. doi: 10.1016/j.ajhg.2008.01.015. Epub 2008 Mar 20.

9.

Novel GIGYF2 gene variants in patients with Parkinson's disease in Chinese population.

Wang L, Guo JF, Zhang WW, Xu Q, Zuo X, Shi CH, Luo LZ, Liu J, Hu L, Hu YC, She L, Jiang H, Yan XX, Xia K, Pan Q, Tang BS.

Neurosci Lett. 2010 Apr 5;473(2):131-5. doi: 10.1016/j.neulet.2010.02.037. Epub 2010 Feb 21.

PMID:
20178831
10.
11.

PTP1B deficiency enhances liver growth during suckling by increasing the expression of insulin-like growth factor-I.

Escrivá F, González-Rodriguez A, Fernández-Millán E, Rondinone CM, Alvarez C, Valverde AM.

J Cell Physiol. 2010 Oct;225(1):214-22. doi: 10.1002/jcp.22246.

PMID:
20506299
12.

The adapter protein GRB10 is an endogenous negative regulator of insulin-like growth factor signaling.

Dufresne AM, Smith RJ.

Endocrinology. 2005 Oct;146(10):4399-409. Epub 2005 Jul 21.

PMID:
16037382
13.

The reciprocal regulation of gamma-synuclein and IGF-I receptor expression creates a circuit that modulates IGF-I signaling.

Li M, Yin Y, Hua H, Sun X, Luo T, Wang J, Jiang Y.

J Biol Chem. 2010 Oct 1;285(40):30480-8. doi: 10.1074/jbc.M110.131698. Epub 2010 Jul 29.

14.

GIGYF2 Asn56Ser mutation is rare in Chinese Parkinson's disease patients.

Zhang Y, Zheng L, Zhang T, Wang Y, Xiao Q, Fei QZ, Cui PJ, Cao L, Chen SD.

Neurosci Lett. 2009 Oct 9;463(3):172-5. doi: 10.1016/j.neulet.2009.07.067. Epub 2009 Jul 26.

PMID:
19638301
15.

Follow-up study of the GIGYF2 gene in French families with Parkinson's disease.

Lesage S, Condroyer C, Lohman E, Troiano A, Tison F, Viallet F, Damier P, Tranchant C, Vidhaillet M, Ouvrard-Hernandez AM, Dürr A, Brice A; French Parkinson's Disease Genetics Study Group (FPDGSG).

Neurobiol Aging. 2010 Jun;31(6):1069-71; discussion 1072-4. doi: 10.1016/j.neurobiolaging.2009.06.008. Epub 2009 Dec 8.

PMID:
20004041
16.

Grb10: more than a simple adaptor protein.

Lim MA, Riedel H, Liu F.

Front Biosci. 2004 Jan 1;9:387-403. Review.

PMID:
14766376
17.

Late effects of disturbed IGF signaling in congenital diseases.

Cianfarani S, Geremia C, Puglianiello A, Maiorana A, Germani D.

Endocr Dev. 2007;11:16-27. Review.

PMID:
17986823
18.

Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29.

Rotem-Yehudar R, Galperin E, Horowitz M.

J Biol Chem. 2001 Aug 31;276(35):33054-60. Epub 2001 Jun 21.

19.
20.

Insulin-like growth factor-1-dependent maintenance of neuronal metabolism through the phosphatidylinositol 3-kinase-Akt pathway is inhibited by C2-ceramide in CAD cells.

Arboleda G, Huang TJ, Waters C, Verkhratsky A, Fernyhough P, Gibson RM.

Eur J Neurosci. 2007 May;25(10):3030-8.

PMID:
17561816

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