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Characterization of a novel interaction between transcription factor TFII-I and the inducible tyrosine kinase in T cells.

Sacristán C, Schattgen SA, Berg LJ, Bunnell SC, Roy AL, Rosenstein Y.

Eur J Immunol. 2009 Sep;39(9):2584-95. doi: 10.1002/eji.200839031.


The role of Tec protein-tyrosine kinase in T cell signaling.

Yang WC, Ghiotto M, Barbarat B, Olive D.

J Biol Chem. 1999 Jan 8;274(2):607-17.


Itk, a T cell-specific tyrosine kinase, is required for CD2-mediated interleukin-2 promoter activation in the human T cell line Jurkat.

Tanaka N, Abe H, Yagita H, Okumura K, Nakamura M, Sugamura K.

Eur J Immunol. 1997 Apr;27(4):834-41.


Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation.

Shan X, Czar MJ, Bunnell SC, Liu P, Liu Y, Schwartzberg PL, Wange RL.

Mol Cell Biol. 2000 Sep;20(18):6945-57.


IL-2-inducible T-cell kinase (ITK) finds another (dance) partner...TFII-I.

August A.

Eur J Immunol. 2009 Sep;39(9):2354-7. doi: 10.1002/eji.200939813.


Hematopoietic lineage cell-specific protein 1 is recruited to the immunological synapse by IL-2-inducible T cell kinase and regulates phospholipase Cgamma1 Microcluster dynamics during T cell spreading.

Carrizosa E, Gomez TS, Labno CM, Klos Dehring DA, Liu X, Freedman BD, Billadeau DD, Burkhardt JK.

J Immunol. 2009 Dec 1;183(11):7352-61. doi: 10.4049/jimmunol.0900973.


The SH3 domain of Itk/Emt binds to proline-rich sequences in the cytoplasmic domain of the T cell costimulatory receptor CD28.

Marengère LE, Okkenhaug K, Clavreul A, Couez D, Gibson S, Mills GB, Mak TW, Rottapel R.

J Immunol. 1997 Oct 1;159(7):3220-9. Erratum in: J Immunol 1999 Jul 15;163(2):1092.


Mechanism of Bruton's tyrosine kinase-mediated recruitment and regulation of TFII-I.

Sacristán C, Tussié-Luna MI, Logan SM, Roy AL.

J Biol Chem. 2004 Feb 20;279(8):7147-58.


A conserved motif in the ITK PH-domain is required for phosphoinositide binding and TCR signaling but dispensable for adaptor protein interactions.

Hirve N, Levytskyy RM, Rigaud S, Guimond DM, Zal T, Sauer K, Tsoukas CD.

PLoS One. 2012;7(9):e45158. doi: 10.1371/journal.pone.0045158.


TCR/CD3-Induced activation and binding of Emt/Itk to linker of activated T cell complexes: requirement for the Src homology 2 domain.

Ching KA, Grasis JA, Tailor P, Kawakami Y, Kawakami T, Tsoukas CD.

J Immunol. 2000 Jul 1;165(1):256-62.


A novel function for the Tec family tyrosine kinase Itk in activation of beta 1 integrins by the T-cell receptor.

Woods ML, Kivens WJ, Adelsman MA, Qiu Y, August A, Shimizu Y.

EMBO J. 2001 Mar 15;20(6):1232-44.


Nuclear localization of the tyrosine kinase Itk and interaction of its SH3 domain with karyopherin alpha (Rch1alpha).

Perez-Villar JJ, O'Day K, Hewgill DH, Nadler SG, Kanner SB.

Int Immunol. 2001 Oct;13(10):1265-74.


Emt/Itk associates with activated TCR complexes: role of the pleckstrin homology domain.

Ching KA, Kawakami Y, Kawakami T, Tsoukas CD.

J Immunol. 1999 Dec 1;163(11):6006-13.


Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade.

Bunnell SC, Diehn M, Yaffe MB, Findell PR, Cantley LC, Berg LJ.

J Biol Chem. 2000 Jan 21;275(3):2219-30.

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