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ER stress controls iron metabolism through induction of hepcidin.

Vecchi C, Montosi G, Zhang K, Lamberti I, Duncan SA, Kaufman RJ, Pietrangelo A.

Science. 2009 Aug 14;325(5942):877-80. doi: 10.1126/science.1176639.


Pretreatment with CO-releasing molecules suppresses hepcidin expression during inflammation and endoplasmic reticulum stress through inhibition of the STAT3 and CREBH pathways.

Shin DY, Chung J, Joe Y, Pae HO, Chang KC, Cho GJ, Ryter SW, Chung HT.

Blood. 2012 Mar 15;119(11):2523-32. doi: 10.1182/blood-2011-07-366690. Epub 2012 Jan 19.


Gluconeogenic signals regulate iron homeostasis via hepcidin in mice.

Vecchi C, Montosi G, Garuti C, Corradini E, Sabelli M, Canali S, Pietrangelo A.

Gastroenterology. 2014 Apr;146(4):1060-9. doi: 10.1053/j.gastro.2013.12.016. Epub 2013 Dec 17.


A new wrinkle in the fold: hepcidin links inflammation to the unfolded protein response.

De Domenico I, Kaplan J.

Cell Metab. 2009 Oct;10(4):245-6. doi: 10.1016/j.cmet.2009.09.005.


Iron metabolism in hepcidin1 knockout mice in response to phenylhydrazine-induced hemolysis.

Masaratana P, Latunde-Dada GO, Patel N, Simpson RJ, Vaulont S, McKie AT.

Blood Cells Mol Dis. 2012 Aug 15;49(2):85-91. doi: 10.1016/j.bcmd.2012.04.003. Epub 2012 May 19.


PGC-1α regulates hepatic hepcidin expression and iron homeostasis in response to inflammation.

Qian J, Chen S, Huang Y, Shi X, Liu C.

Mol Endocrinol. 2013 Apr;27(4):683-92. doi: 10.1210/me.2012-1345. Epub 2013 Feb 25.


Regulation of iron metabolism by hepcidin.

Nemeth E, Ganz T.

Annu Rev Nutr. 2006;26:323-42. Review.


Tumor necrosis factor α inhibits expression of the iron regulating hormone hepcidin in murine models of innate colitis.

Shanmugam NK, Ellenbogen S, Trebicka E, Wang L, Mukhopadhyay S, Lacy-Hulbert A, Gallini CA, Garrett WS, Cherayil BJ.

PLoS One. 2012;7(5):e38136. doi: 10.1371/journal.pone.0038136. Epub 2012 May 31.


Orphan nuclear receptor Errγ induces C-reactive protein gene expression through induction of ER-bound Bzip transmembrane transcription factor CREBH.

Misra J, Chanda D, Kim DK, Cho SR, Koo SH, Lee CH, Back SH, Choi HS.

PLoS One. 2014 Jan 22;9(1):e86342. doi: 10.1371/journal.pone.0086342. eCollection 2014. Erratum in: PLoS One. 2015;10(5):e0125536.


Regulation of hepcidin and iron-overload disease.

Lee PL, Beutler E.

Annu Rev Pathol. 2009;4:489-515. doi: 10.1146/annurev.pathol.4.110807.092205. Review.


Low hepcidin accounts for the proinflammatory status associated with iron deficiency.

Pagani A, Nai A, Corna G, Bosurgi L, Rovere-Querini P, Camaschella C, Silvestri L.

Blood. 2011 Jul 21;118(3):736-46. doi: 10.1182/blood-2011-02-337212. Epub 2011 May 31.


Hepcidin regulation of iron transport.

Collins JF, Wessling-Resnick M, Knutson MD.

J Nutr. 2008 Nov;138(11):2284-8. doi: 10.3945/jn.108.096347.


Hepcidin, the recently identified peptide that appears to regulate iron absorption.

Leong WI, Lönnerdal B.

J Nutr. 2004 Jan;134(1):1-4. Review.


Hepcidin, a key regulator of iron metabolism, is transcriptionally activated by p53.

Weizer-Stern O, Adamsky K, Margalit O, Ashur-Fabian O, Givol D, Amariglio N, Rechavi G.

Br J Haematol. 2007 Jul;138(2):253-62.


Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization.

Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, Ganz T, Kaplan J.

Science. 2004 Dec 17;306(5704):2090-3. Epub 2004 Oct 28.


In vivo imaging of hepcidin promoter stimulation by iron and inflammation.

Flanagan JM, Truksa J, Peng H, Lee P, Beutler E.

Blood Cells Mol Dis. 2007 May-Jun;38(3):253-7. Epub 2007 Feb 28.


A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression.

Wang RH, Li C, Xu X, Zheng Y, Xiao C, Zerfas P, Cooperman S, Eckhaus M, Rouault T, Mishra L, Deng CX.

Cell Metab. 2005 Dec;2(6):399-409.


Mechanisms of disease: The role of hepcidin in iron homeostasis--implications for hemochromatosis and other disorders.

Pietrangelo A, Trautwein C.

Nat Clin Pract Gastroenterol Hepatol. 2004 Nov;1(1):39-45. Review.


Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response.

Zhang K, Shen X, Wu J, Sakaki K, Saunders T, Rutkowski DT, Back SH, Kaufman RJ.

Cell. 2006 Feb 10;124(3):587-99.


Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs.

Rivera S, Nemeth E, Gabayan V, Lopez MA, Farshidi D, Ganz T.

Blood. 2005 Sep 15;106(6):2196-9. Epub 2005 Jun 2.

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