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Items: 1 to 20 of 83


Endothelial-specific expression of WNK1 kinase is essential for angiogenesis and heart development in mice.

Xie J, Wu T, Xu K, Huang IK, Cleaver O, Huang CL.

Am J Pathol. 2009 Sep;175(3):1315-27. doi: 10.2353/ajpath.2009.090094. Epub 2009 Jul 30.


WNK1 protein kinase regulates embryonic cardiovascular development through the OSR1 signaling cascade.

Xie J, Yoon J, Yang SS, Lin SH, Huang CL.

J Biol Chem. 2013 Mar 22;288(12):8566-74. doi: 10.1074/jbc.M113.451575. Epub 2013 Feb 5.


Zebrafish WNK lysine deficient protein kinase 1 (wnk1) affects angiogenesis associated with VEGF signaling.

Lai JG, Tsai SM, Tu HC, Chen WC, Kou FJ, Lu JW, Wang HD, Huang CL, Yuh CH.

PLoS One. 2014 Aug 29;9(8):e106129. doi: 10.1371/journal.pone.0106129. eCollection 2014.


Actions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK.

Dbouk HA, Weil LM, Perera GK, Dellinger MT, Pearson G, Brekken RA, Cobb MH.

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):15999-6004. doi: 10.1073/pnas.1419057111. Epub 2014 Oct 31.


Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity.

You LR, Lin FJ, Lee CT, DeMayo FJ, Tsai MJ, Tsai SY.

Nature. 2005 May 5;435(7038):98-104.


Role of the vascular endothelial growth factor isoforms in retinal angiogenesis and DiGeorge syndrome.

Stalmans I.

Verh K Acad Geneeskd Belg. 2005;67(4):229-76. Review.


Cardiovascular expression of the mouse WNK1 gene during development and adulthood revealed by a BAC reporter assay.

Delaloy C, Hadchouel J, Imbert-Teboul M, Clemessy M, Houot AM, Jeunemaitre X.

Am J Pathol. 2006 Jul;169(1):105-18.


Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms.

Lazrak A, Liu Z, Huang CL.

Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1615-20. Epub 2006 Jan 20.


Notch pathway targets proangiogenic regulator Sox17 to restrict angiogenesis.

Lee SH, Lee S, Yang H, Song S, Kim K, Saunders TL, Yoon JK, Koh GY, Kim I.

Circ Res. 2014 Jul 7;115(2):215-26. doi: 10.1161/CIRCRESAHA.115.303142. Epub 2014 Apr 22.


Nuclear receptor COUP-TFII controls pancreatic islet tumor angiogenesis by regulating vascular endothelial growth factor/vascular endothelial growth factor receptor-2 signaling.

Qin J, Chen X, Yu-Lee LY, Tsai MJ, Tsai SY.

Cancer Res. 2010 Nov 1;70(21):8812-21. doi: 10.1158/0008-5472.CAN-10-0551. Epub 2010 Oct 26.


The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development.

Pereira FA, Qiu Y, Zhou G, Tsai MJ, Tsai SY.

Genes Dev. 1999 Apr 15;13(8):1037-49.


WNK1/HSN2 mutation in human peripheral neuropathy deregulates KCC2 expression and posterior lateral line development in zebrafish (Danio rerio).

Bercier V, Brustein E, Liao M, Dion PA, Lafrenière RG, Rouleau GA, Drapeau P.

PLoS Genet. 2013;9(1):e1003124. doi: 10.1371/journal.pgen.1003124. Epub 2013 Jan 3.


COUP-TFII is a major regulator of cell cycle and Notch signaling pathways.

Chen X, Qin J, Cheng CM, Tsai MJ, Tsai SY.

Mol Endocrinol. 2012 Aug;26(8):1268-77. doi: 10.1210/me.2011-1305. Epub 2012 Jun 25.


Essential roles of COUP-TFII in Leydig cell differentiation and male fertility.

Qin J, Tsai MJ, Tsai SY.

PLoS One. 2008 Sep 26;3(9):e3285. doi: 10.1371/journal.pone.0003285.


Arterial-venous specification during development.

Swift MR, Weinstein BM.

Circ Res. 2009 Mar 13;104(5):576-88. doi: 10.1161/CIRCRESAHA.108.188805. Review.


WNK1-related Familial Hyperkalemic Hypertension results from an increased expression of L-WNK1 specifically in the distal nephron.

Vidal-Petiot E, Elvira-Matelot E, Mutig K, Soukaseum C, Baudrie V, Wu S, Cheval L, Huc E, Cambillau M, Bachmann S, Doucet A, Jeunemaitre X, Hadchouel J.

Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14366-71. doi: 10.1073/pnas.1304230110. Epub 2013 Aug 12.


WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II.

Xu B, English JM, Wilsbacher JL, Stippec S, Goldsmith EJ, Cobb MH.

J Biol Chem. 2000 Jun 2;275(22):16795-801.


Tsc1 deficiency-mediated mTOR hyperactivation in vascular endothelial cells causes angiogenesis defects and embryonic lethality.

Ma A, Wang L, Gao Y, Chang Z, Peng H, Zeng N, Gui YS, Tian X, Li X, Cai B, Zhang H, Xu KF.

Hum Mol Genet. 2014 Feb 1;23(3):693-705. doi: 10.1093/hmg/ddt456. Epub 2013 Sep 18.


Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform.

Subramanya AR, Yang CL, Zhu X, Ellison DH.

Am J Physiol Renal Physiol. 2006 Mar;290(3):F619-24. Epub 2005 Oct 4.

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