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Items: 1 to 20 of 98

1.

No increases in biomarkers of genetic damage or pathological changes in heart and brain tissues in male rats administered methylphenidate hydrochloride (Ritalin) for 28 days.

Witt KL, Malarkey DE, Hobbs CA, Davis JP, Kissling GE, Caspary W, Travlos G, Recio L.

Environ Mol Mutagen. 2010 Jan;51(1):80-8. doi: 10.1002/em.20515.

2.

DNA damage in rats after treatment with methylphenidate.

Andreazza AC, Frey BN, Valvassori SS, Zanotto C, Gomes KM, Comim CM, Cassini C, Stertz L, Ribeiro LC, Quevedo J, Kapczinski F, Berk M, Gonçalves CA.

Prog Neuropsychopharmacol Biol Psychiatry. 2007 Aug 15;31(6):1282-8. Epub 2007 Jun 2.

PMID:
17614179
3.

Flow cytometric detection of Pig-A mutant red blood cells using an erythroid-specific antibody: application of the method for evaluating the in vivo genotoxicity of methylphenidate in adolescent rats.

Dobrovolsky VN, Boctor SY, Twaddle NC, Doerge DR, Bishop ME, Manjanatha MG, Kimoto T, Miura D, Heflich RH, Ferguson SA.

Environ Mol Mutagen. 2010 Mar;51(2):138-45. doi: 10.1002/em.20519.

PMID:
19658152
4.

No elevated genomic damage in children and adolescents with attention deficit/hyperactivity disorder after methylphenidate therapy.

Walitza S, Kämpf K, Artamonov N, Romanos M, Gnana Oli R, Wirth S, Warnke A, Gerlach M, Stopper H.

Toxicol Lett. 2009 Jan 10;184(1):38-43. doi: 10.1016/j.toxlet.2008.10.011. Epub 2008 Oct 28.

PMID:
19015014
5.

Methylphenidate increases glucose uptake in the brain of young and adult rats.

Réus GZ, Scaini G, Titus SE, Furlanetto CB, Wessler LB, Ferreira GK, Gonçalves CL, Jeremias GC, Quevedo J, Streck EL.

Pharmacol Rep. 2015 Oct;67(5):1033-40. doi: 10.1016/j.pharep.2015.03.005. Epub 2015 Mar 23.

PMID:
26398400
6.

Methylphenidate regulates c-fos and fosB expression in multiple regions of the immature rat brain.

Chase TD, Carrey N, Brown RE, Wilkinson M.

Brain Res Dev Brain Res. 2005 Apr 21;156(1):1-12.

PMID:
15862622
7.

Early postnatal exposure to methylphenidate alters stress reactivity and increases hippocampal ectopic granule cells in adult rats.

Torres-Reveron A, Gray JD, Melton JT, Punsoni M, Tabori NE, Ward MJ, Frys K, Iadecola C, Milner TA.

Brain Res Bull. 2009 Mar 16;78(4-5):175-81. doi: 10.1016/j.brainresbull.2008.11.009. Epub 2008 Dec 25.

8.

Evaluation of mutagenic mode of action in Big Blue mice fed methylphenidate for 24 weeks.

Manjanatha MG, Shelton SD, Dobrovolsky VN, Shaddock JG, McGarrity LG, Twaddle NW, Moore MM, Mattison DR, Slikker W Jr, Morris SM.

Mutat Res. 2009 Nov-Dec;680(1-2):43-8. doi: 10.1016/j.mrgentox.2009.09.004. Epub 2009 Sep 22.

PMID:
19778631
9.

Brain apoptosis signaling pathways are regulated by methylphenidate treatment in young and adult rats.

Réus GZ, Scaini G, Jeremias GC, Furlanetto CB, Morais MO, Mello-Santos LM, Quevedo J, Streck EL.

Brain Res. 2014 Oct 2;1583:269-76. doi: 10.1016/j.brainres.2014.08.010. Epub 2014 Aug 13.

PMID:
25128604
10.

Inhibition of mitochondrial respiratory chain in the brain of adult rats after acute and chronic administration of methylphenidate.

Fagundes AO, Scaini G, Santos PM, Sachet MU, Bernhardt NM, Rezin GT, Valvassori SS, Schuck PF, Quevedo J, Streck EL.

Neurochem Res. 2010 Mar;35(3):405-11. doi: 10.1007/s11064-009-0069-7. Epub 2009 Sep 24.

PMID:
19777344
11.
12.

Methylphenidate increases creatine kinase activity in the brain of young and adult rats.

Scaini G, Fagundes AO, Rezin GT, Gomes KM, Zugno AI, Quevedo J, Streck EL.

Life Sci. 2008 Dec 5;83(23-24):795-800. doi: 10.1016/j.lfs.2008.09.019. Epub 2008 Oct 5.

PMID:
18938183
13.

1H MRS-detectable metabolic brain changes and reduced impulsive behavior in adult rats exposed to methylphenidate during adolescence.

Adriani W, Canese R, Podo F, Laviola G.

Neurotoxicol Teratol. 2007 Jan-Feb;29(1):116-25. Epub 2006 Dec 6.

PMID:
17196789
14.

The genetic toxicology of methylphenidate hydrochloride in non-human primates.

Morris SM, Dobrovolsky VN, Shaddock JG, Mittelstaedt RA, Bishop ME, Manjanatha MG, Shelton SD, Doerge DR, Twaddle NC, Chen JJ, Lin CJ, Paule MG, Slikker W Jr, Hotchkiss CE, Petibone D, Tucker JD, Mattison DR.

Mutat Res. 2009 Feb 19;673(1):59-66. doi: 10.1016/j.mrgentox.2008.12.001. Epub 2008 Dec 24.

PMID:
19135169
15.

Cytogenetic assessment of methylphenidate treatment in pediatric patients treated for attention deficit hyperactivity disorder.

Tucker JD, Suter W, Petibone DM, Thomas RA, Bailey NL, Zhou Y, Zhao Y, Muniz R, Kumar V.

Mutat Res. 2009 Jun-Jul;677(1-2):53-8. doi: 10.1016/j.mrgentox.2009.05.005. Epub 2009 May 22.

PMID:
19465145
16.

Genotoxicity of styrene-acrylonitrile trimer in brain, liver, and blood cells of weanling F344 rats.

Hobbs CA, Chhabra RS, Recio L, Streicker M, Witt KL.

Environ Mol Mutagen. 2012 Apr;53(3):227-38. doi: 10.1002/em.21680. Epub 2012 Feb 20.

17.

Methylphenidate treatment induces oxidative stress in young rat brain.

Martins MR, Reinke A, Petronilho FC, Gomes KM, Dal-Pizzol F, Quevedo J.

Brain Res. 2006 Mar 17;1078(1):189-97. Epub 2006 Feb 21.

PMID:
16494852
18.

Antioxidant enzyme activities following acute or chronic methylphenidate treatment in young rats.

Gomes KM, Petronilho FC, Mantovani M, Garbelotto T, Boeck CR, Dal-Pizzol F, Quevedo J.

Neurochem Res. 2008 Jun;33(6):1024-7. Epub 2007 Nov 30.

PMID:
18049893
19.

Methylphenidate differentially regulates c-fos and fosB expression in the developing rat striatum.

Chase TD, Carrey N, Brown RE, Wilkinson M.

Brain Res Dev Brain Res. 2005 Jun 30;157(2):181-91.

PMID:
15916815
20.

Treadmill exercise and methylphenidate ameliorate symptoms of attention deficit/hyperactivity disorder through enhancing dopamine synthesis and brain-derived neurotrophic factor expression in spontaneous hypertensive rats.

Kim H, Heo HI, Kim DH, Ko IG, Lee SS, Kim SE, Kim BK, Kim TW, Ji ES, Kim JD, Shin MS, Choi YW, Kim CJ.

Neurosci Lett. 2011 Oct 17;504(1):35-9. doi: 10.1016/j.neulet.2011.08.052. Epub 2011 Aug 31.

PMID:
21907264

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