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Items: 1 to 20 of 68


A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging.

Murga M, Bunting S, Montaña MF, Soria R, Mulero F, Cañamero M, Lee Y, McKinnon PJ, Nussenzweig A, Fernandez-Capetillo O.

Nat Genet. 2009 Aug;41(8):891-8. doi: 10.1038/ng.420. Epub 2009 Jul 20.


Life can be stressful without ATR.

O'Driscoll M.

Nat Genet. 2009 Aug;41(8):866-8. doi: 10.1038/ng0809-866. No abstract available.


Small molecule inhibition of p38 MAP kinase extends the replicative life span of human ATR-Seckel syndrome fibroblasts.

Tivey HS, Rokicki MJ, Barnacle JR, Rogers MJ, Bagley MC, Kipling D, Davis T.

J Gerontol A Biol Sci Med Sci. 2013 Sep;68(9):1001-9. doi: 10.1093/gerona/gls336. Epub 2013 Feb 11.


Mice lacking protein phosphatase 5 are defective in ataxia telangiectasia mutated (ATM)-mediated cell cycle arrest.

Yong W, Bao S, Chen H, Li D, Sánchez ER, Shou W.

J Biol Chem. 2007 May 18;282(20):14690-4. Epub 2007 Mar 21.


ATR-p53 restricts homologous recombination in response to replicative stress but does not limit DNA interstrand crosslink repair in lung cancer cells.

Sirbu BM, Lachmayer SJ, Wülfing V, Marten LM, Clarkson KE, Lee LW, Gheorghiu L, Zou L, Powell SN, Dahm-Daphi J, Willers H.

PLoS One. 2011;6(8):e23053. doi: 10.1371/journal.pone.0023053. Epub 2011 Aug 12.


Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors.

Murga M, Campaner S, Lopez-Contreras AJ, Toledo LI, Soria R, Montaña MF, Artista L, Schleker T, Guerra C, Garcia E, Barbacid M, Hidalgo M, Amati B, Fernandez-Capetillo O.

Nat Struct Mol Biol. 2011 Nov 27;18(12):1331-1335. doi: 10.1038/nsmb.2189.


ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency.

Cao L, Kim S, Xiao C, Wang RH, Coumoul X, Wang X, Li WM, Xu XL, De Soto JA, Takai H, Mai S, Elledge SJ, Motoyama N, Deng CX.

EMBO J. 2006 May 17;25(10):2167-77. Epub 2006 May 4.


ATR kinase is required for global genomic nucleotide excision repair exclusively during S phase in human cells.

Auclair Y, Rouget R, Affar el B, Drobetsky EA.

Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17896-901. doi: 10.1073/pnas.0801585105. Epub 2008 Nov 11.


The role of NBS1 in the modulation of PIKK family proteins ATM and ATR in the cellular response to DNA damage.

Zhou J, Lim CU, Li JJ, Cai L, Zhang Y.

Cancer Lett. 2006 Nov 8;243(1):9-15. Epub 2006 Mar 10. Review.


ATR and H2AX cooperate in maintaining genome stability under replication stress.

Chanoux RA, Yin B, Urtishak KA, Asare A, Bassing CH, Brown EJ.

J Biol Chem. 2009 Feb 27;284(9):5994-6003. doi: 10.1074/jbc.M806739200. Epub 2008 Dec 2.


DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A.

Liu Y, Rusinol A, Sinensky M, Wang Y, Zou Y.

J Cell Sci. 2006 Nov 15;119(Pt 22):4644-9. Epub 2006 Oct 24.


p53-Independent apoptosis disrupts early organogenesis in embryos lacking both ataxia-telangiectasia mutated and Prkdc.

Gladdy RA, Nutter LM, Kunath T, Danska JS, Guidos CJ.

Mol Cancer Res. 2006 May;4(5):311-8.


ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase.

McNees CJ, Tejera AM, Martínez P, Murga M, Mulero F, Fernandez-Capetillo O, Blasco MA.

J Cell Biol. 2010 Mar 8;188(5):639-52. doi: 10.1083/jcb.200908136.


DNA-PK, ATM and ATR collaboratively regulate p53-RPA interaction to facilitate homologous recombination DNA repair.

Serrano MA, Li Z, Dangeti M, Musich PR, Patrick S, Roginskaya M, Cartwright B, Zou Y.

Oncogene. 2013 May 9;32(19):2452-62. doi: 10.1038/onc.2012.257. Epub 2012 Jul 16.


Tel2 regulates the stability of PI3K-related protein kinases.

Takai H, Wang RC, Takai KK, Yang H, de Lange T.

Cell. 2007 Dec 28;131(7):1248-59.


Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.

Denchi EL, de Lange T.

Nature. 2007 Aug 30;448(7157):1068-71. Epub 2007 Aug 8.


Cell-cycle checkpoint kinases: checking in on the cell cycle.

Walworth NC.

Curr Opin Cell Biol. 2000 Dec;12(6):697-704. Review.


Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis.

Maclean KH, Dorsey FC, Cleveland JL, Kastan MB.

J Clin Invest. 2008 Jan;118(1):79-88. Erratum in: J Clin Invest. 2008 Apr;118(4):1584.

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