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Items: 1 to 20 of 355

1.

Impaired balance of mitochondrial fission and fusion in Alzheimer's disease.

Wang X, Su B, Lee HG, Li X, Perry G, Smith MA, Zhu X.

J Neurosci. 2009 Jul 15;29(28):9090-103. doi: 10.1523/JNEUROSCI.1357-09.2009.

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3.

Inhibition of ERK-DLP1 signaling and mitochondrial division alleviates mitochondrial dysfunction in Alzheimer's disease cybrid cell.

Gan X, Huang S, Wu L, Wang Y, Hu G, Li G, Zhang H, Yu H, Swerdlow RH, Chen JX, Yan SS.

Biochim Biophys Acta. 2014 Feb;1842(2):220-31. doi: 10.1016/j.bbadis.2013.11.009. Epub 2013 Nov 16.

4.

Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins.

Wang X, Su B, Siedlak SL, Moreira PI, Fujioka H, Wang Y, Casadesus G, Zhu X.

Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19318-23. doi: 10.1073/pnas.0804871105. Epub 2008 Dec 2.

5.

Leucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like protein.

Niu J, Yu M, Wang C, Xu Z.

J Neurochem. 2012 Aug;122(3):650-8. doi: 10.1111/j.1471-4159.2012.07809.x. Epub 2012 Jun 22.

7.

Parkinson's disease-associated DJ-1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction.

Wang X, Petrie TG, Liu Y, Liu J, Fujioka H, Zhu X.

J Neurochem. 2012 Jun;121(5):830-9. doi: 10.1111/j.1471-4159.2012.07734.x. Epub 2012 Apr 12.

8.

Aβ-Induced Drp1 phosphorylation through Akt activation promotes excessive mitochondrial fission leading to neuronal apoptosis.

Kim DI, Lee KH, Gabr AA, Choi GE, Kim JS, Ko SH, Han HJ.

Biochim Biophys Acta. 2016 Nov;1863(11):2820-2834. doi: 10.1016/j.bbamcr.2016.09.003. Epub 2016 Sep 4.

PMID:
27599716
9.

Appoptosin interacts with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology.

Zhang C, Shi Z, Zhang L, Zhou Z, Zheng X, Liu G, Bu G, Fraser PE, Xu H, Zhang YW.

J Cell Sci. 2016 Mar 1;129(5):994-1002. doi: 10.1242/jcs.176792. Epub 2016 Jan 26.

10.

Protective effects of reduced dynamin-related protein 1 against amyloid beta-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease.

Manczak M, Kandimalla R, Fry D, Sesaki H, Reddy PH.

Hum Mol Genet. 2016 Dec 1;25(23):5148-5166. doi: 10.1093/hmg/ddw330.

PMID:
27677309
11.

Mitofusin2 mutations disrupt axonal mitochondrial positioning and promote axon degeneration.

Misko AL, Sasaki Y, Tuck E, Milbrandt J, Baloh RH.

J Neurosci. 2012 Mar 21;32(12):4145-55. doi: 10.1523/JNEUROSCI.6338-11.2012.

12.

S-Nitrosylation of DRP1 does not affect enzymatic activity and is not specific to Alzheimer's disease.

Bossy B, Petrilli A, Klinglmayr E, Chen J, Lütz-Meindl U, Knott AB, Masliah E, Schwarzenbacher R, Bossy-Wetzel E.

J Alzheimers Dis. 2010;20 Suppl 2:S513-26. doi: 10.3233/JAD-2010-100552.

13.

Loss of Drp1 function alters OPA1 processing and changes mitochondrial membrane organization.

Möpert K, Hajek P, Frank S, Chen C, Kaufmann J, Santel A.

Exp Cell Res. 2009 Aug 1;315(13):2165-80. doi: 10.1016/j.yexcr.2009.04.016. Epub 2009 May 3.

PMID:
19409380
14.

Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases.

Reddy PH, Reddy TP, Manczak M, Calkins MJ, Shirendeb U, Mao P.

Brain Res Rev. 2011 Jun 24;67(1-2):103-18. doi: 10.1016/j.brainresrev.2010.11.004. Epub 2010 Dec 8. Review.

15.

Neural stem cell transplantation enhances mitochondrial biogenesis in a transgenic mouse model of Alzheimer's disease-like pathology.

Zhang W, Gu GJ, Shen X, Zhang Q, Wang GM, Wang PJ.

Neurobiol Aging. 2015 Mar;36(3):1282-92. doi: 10.1016/j.neurobiolaging.2014.10.040. Epub 2014 Dec 18.

PMID:
25582749
16.

Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's disease.

Sheng B, Wang X, Su B, Lee HG, Casadesus G, Perry G, Zhu X.

J Neurochem. 2012 Feb;120(3):419-29. doi: 10.1111/j.1471-4159.2011.07581.x. Epub 2011 Dec 8.

17.

Extracellular signal-regulated kinase is involved in alpha-synuclein-induced mitochondrial dynamic disorders by regulating dynamin-like protein 1.

Gui YX, Wang XY, Kang WY, Zhang YJ, Zhang Y, Zhou Y, Quinn TJ, Liu J, Chen SD.

Neurobiol Aging. 2012 Dec;33(12):2841-54. doi: 10.1016/j.neurobiolaging.2012.02.001. Epub 2012 Mar 22.

PMID:
22445325
18.

LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1.

Wang X, Yan MH, Fujioka H, Liu J, Wilson-Delfosse A, Chen SG, Perry G, Casadesus G, Zhu X.

Hum Mol Genet. 2012 May 1;21(9):1931-44. doi: 10.1093/hmg/dds003. Epub 2012 Jan 6.

19.

S-nitrosylation of Drp1 links excessive mitochondrial fission to neuronal injury in neurodegeneration.

Nakamura T, Cieplak P, Cho DH, Godzik A, Lipton SA.

Mitochondrion. 2010 Aug;10(5):573-8. doi: 10.1016/j.mito.2010.04.007. Epub 2010 May 4. Review.

20.

S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury.

Cho DH, Nakamura T, Fang J, Cieplak P, Godzik A, Gu Z, Lipton SA.

Science. 2009 Apr 3;324(5923):102-5. doi: 10.1126/science.1171091.

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