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Toxoplasma gondii cathepsin L is the primary target of the invasion-inhibitory compound morpholinurea-leucyl-homophenyl-vinyl sulfone phenyl.

Larson ET, Parussini F, Huynh MH, Giebel JD, Kelley AM, Zhang L, Bogyo M, Merritt EA, Carruthers VB.

J Biol Chem. 2009 Sep 25;284(39):26839-50. doi: 10.1074/jbc.M109.003780. Epub 2009 Jul 13.


The cathepsin L of Toxoplasma gondii (TgCPL) and its endogenous macromolecular inhibitor, toxostatin.

Huang R, Que X, Hirata K, Brinen LS, Lee JH, Hansell E, Engel J, Sajid M, Reed S.

Mol Biochem Parasitol. 2009 Mar;164(1):86-94. doi: 10.1016/j.molbiopara.2008.11.012. Epub 2008 Dec 6.


Cysteine protease inhibitors block Toxoplasma gondii microneme secretion and cell invasion.

Teo CF, Zhou XW, Bogyo M, Carruthers VB.

Antimicrob Agents Chemother. 2007 Feb;51(2):679-88. Epub 2006 Dec 4.


Toxoplasma gondii cathepsin proteases are undeveloped prominent vaccine antigens against toxoplasmosis.

Zhao G, Zhou A, Lv G, Meng M, Sun M, Bai Y, Han Y, Wang L, Zhou H, Cong H, Zhao Q, Zhu XQ, He S.

BMC Infect Dis. 2013 May 7;13:207. doi: 10.1186/1471-2334-13-207.


The cathepsin B of Toxoplasma gondii, toxopain-1, is critical for parasite invasion and rhoptry protein processing.

Que X, Ngo H, Lawton J, Gray M, Liu Q, Engel J, Brinen L, Ghosh P, Joiner KA, Reed SL.

J Biol Chem. 2002 Jul 12;277(28):25791-7. Epub 2002 May 8.


Crystal structure of the parasite protease inhibitor chagasin in complex with a host target cysteine protease.

Ljunggren A, Redzynia I, Alvarez-Fernandez M, Abrahamson M, Mort JS, Krupa JC, Jaskolski M, Bujacz G.

J Mol Biol. 2007 Aug 3;371(1):137-53. Epub 2007 May 10.


Cathepsin proteases in Toxoplasma gondii.

Dou Z, Carruthers VB.

Adv Exp Med Biol. 2011;712:49-61. doi: 10.1007/978-1-4419-8414-2_4. Review.


Identification of a new class of nonpeptidic inhibitors of cruzain.

Brak K, Doyle PS, McKerrow JH, Ellman JA.

J Am Chem Soc. 2008 May 21;130(20):6404-10. doi: 10.1021/ja710254m. Epub 2008 Apr 25.


Crystal structure of human cathepsin V.

Somoza JR, Zhan H, Bowman KK, Yu L, Mortara KD, Palmer JT, Clark JM, McGrath ME.

Biochemistry. 2000 Oct 17;39(41):12543-51. Erratum in: Biochemistry 2001 Apr 3;40(13):4200.


Cathepsin L occupies a vacuolar compartment and is a protein maturase within the endo/exocytic system of Toxoplasma gondii.

Parussini F, Coppens I, Shah PP, Diamond SL, Carruthers VB.

Mol Microbiol. 2010 Jun;76(6):1340-57. doi: 10.1111/j.1365-2958.2010.07181.x. Epub 2010 Apr 23.


Non-canonical maturation of two papain-family proteases in Toxoplasma gondii.

Dou Z, Coppens I, Carruthers VB.

J Biol Chem. 2013 Feb 1;288(5):3523-34. doi: 10.1074/jbc.M112.443697. Epub 2012 Dec 18.


Cathepsin Cs are key for the intracellular survival of the protozoan parasite, Toxoplasma gondii.

Que X, Engel JC, Ferguson D, Wunderlich A, Tomavo S, Reed SL.

J Biol Chem. 2007 Feb 16;282(7):4994-5003. Epub 2006 Dec 12.


In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi.

Chen YT, Brinen LS, Kerr ID, Hansell E, Doyle PS, McKerrow JH, Roush WR.

PLoS Negl Trop Dis. 2010 Sep 14;4(9). pii: e825. doi: 10.1371/journal.pntd.0000825.


Synthesis of macrocyclic trypanosomal cysteine protease inhibitors.

Chen YT, Lira R, Hansell E, McKerrow JH, Roush WR.

Bioorg Med Chem Lett. 2008 Nov 15;18(22):5860-3. doi: 10.1016/j.bmcl.2008.06.012. Epub 2008 Jun 10.


Development of peptidomimetics with a vinyl sulfone warhead as irreversible falcipain-2 inhibitors.

Ettari R, Nizi E, Di Francesco ME, Dude MA, Pradel G, Vicík R, Schirmeister T, Micale N, Grasso S, Zappalà M.

J Med Chem. 2008 Feb 28;51(4):988-96. doi: 10.1021/jm701141u. Epub 2008 Jan 31.


Structural basis for the regulation of cysteine-protease activity by a new class of protease inhibitors in Plasmodium.

Hansen G, Heitmann A, Witt T, Li H, Jiang H, Shen X, Heussler VT, Rennenberg A, Hilgenfeld R.

Structure. 2011 Jul 13;19(7):919-29. doi: 10.1016/j.str.2011.03.025.


Identification and characterization of a cathepsin L-like cysteine protease from Gnathostoma spinigerum.

Kongkerd N, Uparanukraw P, Morakote N, Sajid M, McKerrow JH.

Mol Biochem Parasitol. 2008 Aug;160(2):129-37. doi: 10.1016/j.molbiopara.2008.05.001. Epub 2008 May 8.


Crystal structure of the parasite inhibitor chagasin in complex with papain allows identification of structural requirements for broad reactivity and specificity determinants for target proteases.

Redzynia I, Ljunggren A, Bujacz A, Abrahamson M, Jaskolski M, Bujacz G.

FEBS J. 2009 Feb;276(3):793-806. doi: 10.1111/j.1742-4658.2008.06824.x.


Peptidyl allyl sulfones: a new class of inhibitors for clan CA cysteine proteases.

Götz MG, Caffrey CR, Hansell E, McKerrow JH, Powers JC.

Bioorg Med Chem. 2004 Oct 1;12(19):5203-11.


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