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Items: 1 to 20 of 91

1.

REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A-DDB1 ubiquitin ligase.

Katiyar S, Liu E, Knutzen CA, Lang ES, Lombardo CR, Sankar S, Toth JI, Petroski MD, Ronai Z, Chiang GG.

EMBO Rep. 2009 Aug;10(8):866-72. doi: 10.1038/embor.2009.93.

2.

mTORC1 dependent regulation of REDD1 protein stability.

Tan CY, Hagen T.

PLoS One. 2013 May 22;8(5):e63970. doi: 10.1371/journal.pone.0063970.

4.

mTORC1 signaling requires proteasomal function and the involvement of CUL4-DDB1 ubiquitin E3 ligase.

Ghosh P, Wu M, Zhang H, Sun H.

Cell Cycle. 2008 Feb 1;7(3):373-81.

PMID:
18235224
5.

A novel mechanism by which thiazolidinediones facilitate the proteasomal degradation of cyclin D1 in cancer cells.

Wei S, Yang HC, Chuang HC, Yang J, Kulp SK, Lu PJ, Lai MD, Chen CS.

J Biol Chem. 2008 Sep 26;283(39):26759-70. doi: 10.1074/jbc.M802160200.

6.

WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase.

Hu J, Zacharek S, He YJ, Lee H, Shumway S, Duronio RJ, Xiong Y.

Genes Dev. 2008 Apr 1;22(7):866-71. doi: 10.1101/gad.1624008.

7.

Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery.

Angers S, Li T, Yi X, MacCoss MJ, Moon RT, Zheng N.

Nature. 2006 Oct 5;443(7111):590-3.

PMID:
16964240
8.

Acute alcohol intoxication increases REDD1 in skeletal muscle.

Lang CH, Frost RA, Vary TC.

Alcohol Clin Exp Res. 2008 May;32(5):796-805. doi: 10.1111/j.1530-0277.2008.00637.x.

PMID:
18336631
9.

Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling.

DeYoung MP, Horak P, Sofer A, Sgroi D, Ellisen LW.

Genes Dev. 2008 Jan 15;22(2):239-51. doi: 10.1101/gad.1617608.

10.
11.

Cullin-4A┬ĚDNA damage-binding protein 1 E3 ligase complex targets tumor suppressor RASSF1A for degradation during mitosis.

Jiang L, Rong R, Sheikh MS, Huang Y.

J Biol Chem. 2011 Mar 4;286(9):6971-8. doi: 10.1074/jbc.M110.186494.

12.

DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress.

Leung-Pineda V, Huh J, Piwnica-Worms H.

Cancer Res. 2009 Mar 15;69(6):2630-7. doi: 10.1158/0008-5472.CAN-08-3382.

13.

VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation.

Huang J, Chen J.

Oncogene. 2008 Jul 3;27(29):4056-64. doi: 10.1038/onc.2008.44.

PMID:
18332868
14.

The oral iron chelator deferasirox represses signaling through the mTOR in myeloid leukemia cells by enhancing expression of REDD1.

Ohyashiki JH, Kobayashi C, Hamamura R, Okabe S, Tauchi T, Ohyashiki K.

Cancer Sci. 2009 May;100(5):970-7. doi: 10.1111/j.1349-7006.2009.01131.x.

15.

L2DTL/CDT2 and PCNA interact with p53 and regulate p53 polyubiquitination and protein stability through MDM2 and CUL4A/DDB1 complexes.

Banks D, Wu M, Higa LA, Gavrilova N, Quan J, Ye T, Kobayashi R, Sun H, Zhang H.

Cell Cycle. 2006 Aug;5(15):1719-29.

PMID:
16861890
16.

Regulation of mTOR and cell growth in response to energy stress by REDD1.

Sofer A, Lei K, Johannessen CM, Ellisen LW.

Mol Cell Biol. 2005 Jul;25(14):5834-45.

17.
18.

Growth control under stress: mTOR regulation through the REDD1-TSC pathway.

Ellisen LW.

Cell Cycle. 2005 Nov;4(11):1500-02. Review.

PMID:
16258273
19.

CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation.

Higa LA, Wu M, Ye T, Kobayashi R, Sun H, Zhang H.

Nat Cell Biol. 2006 Nov;8(11):1277-83.

PMID:
17041588
20.
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