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Activated integrin VLA-4 localizes to the lamellipodia and mediates T cell migration on VCAM-1.

Hyun YM, Chung HL, McGrath JL, Waugh RE, Kim M.

J Immunol. 2009 Jul 1;183(1):359-69. doi: 10.4049/jimmunol.0803388.


Influence of beta 1 integrin intracytoplasmic domains in the regulation of VLA-4-mediated adhesion of human T cells to VCAM-1 under flow conditions.

Rosenthal-Allieri MA, Ticchioni M, Breittmayer JP, Shimizu Y, Bernard A.

J Immunol. 2005 Jul 15;175(2):1214-23.


High affinity very late antigen-4 subsets expressed on T cells are mandatory for spontaneous adhesion strengthening but not for rolling on VCAM-1 in shear flow.

Chen C, Mobley JL, Dwir O, Shimron F, Grabovsky V, Lobb RR, Shimizu Y, Alon R.

J Immunol. 1999 Jan 15;162(2):1084-95.


Differing requirements for CCR4, E-selectin, and α4β1 for the migration of memory CD4 and activated T cells to dermal inflammation.

Gehad A, Al-Banna NA, Vaci M, Issekutz AC, Mohan K, Latta M, Issekutz TB.

J Immunol. 2012 Jul 1;189(1):337-46. doi: 10.4049/jimmunol.1102315. Epub 2012 Jun 4.


The Src kinase p56(lck) up-regulates VLA-4 integrin affinity. Implications for rapid spontaneous and chemokine-triggered T cell adhesion to VCAM-1 and fibronectin.

Feigelson SW, Grabovsky V, Winter E, Chen LL, Pepinsky RB, Yednock T, Yablonski D, Lobb R, Alon R.

J Biol Chem. 2001 Apr 27;276(17):13891-901. Epub 2000 Dec 1.


Effects of the very late adhesion molecule 4 antagonist WAY103 on human peripheral blood eosinophil vascular cell adhesion molecule 1-dependent functions.

Sedgwick JB, Jansen KJ, Kennedy JD, Kita H, Busse WW.

J Allergy Clin Immunol. 2005 Oct;116(4):812-9. Epub 2005 Aug 24.


Regulation of human basophil adhesion to endothelium under flow conditions: Different very late antigen 4 regulation on umbilical cord blood-derived and peripheral blood basophils.

Kepley CL, Andrews RP, Brown DC, Chigaev A, Sklar LA, Oliver JM, Larson RS.

J Allergy Clin Immunol. 2002 Sep;110(3):469-75.


Functional relevance during lymphocyte migration and cellular localization of activated beta1 integrins.

Gómez M, Luque A, del Pozo MA, Hogg N, Sánchez-Madrid F, Cabañas C.

Eur J Immunol. 1997 Jan;27(1):8-16.


CXCR4 and vascular cell adhesion molecule 1 are key chemokine/adhesion receptors in the migration of cytokine-activated T cells.

Bryant J, Ahern DJ, Brennan FM.

Arthritis Rheum. 2012 Jul;64(7):2137-46. doi: 10.1002/art.34394.


Cross talk between alpha(v)beta3 and alpha4beta1 integrins regulates lymphocyte migration on vascular cell adhesion molecule 1.

Imhof BA, Weerasinghe D, Brown EJ, Lindberg FP, Hammel P, Piali L, Dessing M, Gisler R.

Eur J Immunol. 1997 Dec;27(12):3242-52.


The roles of adhesion molecules and proteinases in lymphocyte transendothelial migration.

Madri JA, Graesser D, Haas T.

Biochem Cell Biol. 1996;74(6):749-57. Review.


Determinants of human B cell migration across brain endothelial cells.

Alter A, Duddy M, Hebert S, Biernacki K, Prat A, Antel JP, Yong VW, Nuttall RK, Pennington CJ, Edwards DR, Bar-Or A.

J Immunol. 2003 May 1;170(9):4497-505.


Essential role for Rap1 GTPase and its guanine exchange factor CalDAG-GEFI in LFA-1 but not VLA-4 integrin mediated human T-cell adhesion.

Ghandour H, Cullere X, Alvarez A, Luscinskas FW, Mayadas TN.

Blood. 2007 Nov 15;110(10):3682-90. Epub 2007 Aug 16.


Inhibition of eosinophilia in vivo by a small molecule inhibitor of very late antigen (VLA)-4.

Okigami H, Takeshita K, Tajimi M, Komura H, Albers M, Lehmann TE, Rölle T, Bacon KB.

Eur J Pharmacol. 2007 Mar 22;559(2-3):202-9. Epub 2006 Dec 12.


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