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The initial phase of an immune response functions to activate regulatory T cells.

O'Gorman WE, Dooms H, Thorne SH, Kuswanto WF, Simonds EF, Krutzik PO, Nolan GP, Abbas AK.

J Immunol. 2009 Jul 1;183(1):332-9. doi: 10.4049/jimmunol.0900691.


Interplay between mTOR and STAT5 signaling modulates the balance between regulatory and effective T cells.

Shan J, Feng L, Sun G, Chen P, Zhou Y, Xia M, Li H, Li Y.

Immunobiology. 2015 Apr;220(4):510-7. doi: 10.1016/j.imbio.2014.10.020. Epub 2014 Oct 31.


Outgrowth of CD4low/negCD25+ T cells with suppressor function in CD4+CD25+ T cell cultures upon polyclonal stimulation ex vivo.

Vogtenhuber C, O'Shaughnessy MJ, Vignali DA, Blazar BR.

J Immunol. 2008 Dec 15;181(12):8767-75.


G protein-coupled receptor 83 overexpression in naive CD4+CD25- T cells leads to the induction of Foxp3+ regulatory T cells in vivo.

Hansen W, Loser K, Westendorf AM, Bruder D, Pfoertner S, Siewert C, Huehn J, Beissert S, Buer J.

J Immunol. 2006 Jul 1;177(1):209-15.


Increased CD127 expression on activated FOXP3+CD4+ regulatory T cells.

Simonetta F, Chiali A, Cordier C, Urrutia A, Girault I, Bloquet S, Tanchot C, Bourgeois C.

Eur J Immunol. 2010 Sep;40(9):2528-38. doi: 10.1002/eji.201040531.


Comparative dose-responses of recombinant human IL-2 and IL-7 on STAT5 phosphorylation in CD4+FOXP3- cells versus regulatory T cells: a whole blood perspective.

Dupont G, Demaret J, Venet F, Malergue F, Malcus C, Poitevin-Later F, Morel J, Monneret G.

Cytokine. 2014 Sep;69(1):146-9. doi: 10.1016/j.cyto.2014.05.021. Epub 2014 Jun 16.


CD25- T cells generate CD25+Foxp3+ regulatory T cells by peripheral expansion.

Curotto de Lafaille MA, Lino AC, Kutchukhidze N, Lafaille JJ.

J Immunol. 2004 Dec 15;173(12):7259-68.


A dynamic dual role of IL-2 signaling in the two-step differentiation process of adaptive regulatory T cells.

Guo Z, Khattar M, Schroder PM, Miyahara Y, Wang G, He X, Chen W, Stepkowski SM.

J Immunol. 2013 Apr 1;190(7):3153-62. doi: 10.4049/jimmunol.1200751. Epub 2013 Feb 20.


Distinct effects of STAT5 activation on CD4+ and CD8+ T cell homeostasis: development of CD4+CD25+ regulatory T cells versus CD8+ memory T cells.

Burchill MA, Goetz CA, Prlic M, O'Neil JJ, Harmon IR, Bensinger SJ, Turka LA, Brennan P, Jameson SC, Farrar MA.

J Immunol. 2003 Dec 1;171(11):5853-64.


Protein kinase B/Akt signals impair Th17 differentiation and support natural regulatory T cell function and induced regulatory T cell formation.

Pierau M, Engelmann S, Reinhold D, Lapp T, Schraven B, Bommhardt UH.

J Immunol. 2009 Nov 15;183(10):6124-34. doi: 10.4049/jimmunol.0900246. Epub 2009 Oct 19.


IL-2 activation of STAT5 enhances production of IL-10 from human cytotoxic regulatory T cells, HOZOT.

Tsuji-Takayama K, Suzuki M, Yamamoto M, Harashima A, Okochi A, Otani T, Inoue T, Sugimoto A, Motoda R, Yamasaki F, Nakamura S, Kibata M.

Exp Hematol. 2008 Feb;36(2):181-92. Epub 2007 Nov 26.


B220+ double-negative T cells suppress polyclonal T cell activation by a Fas-independent mechanism that involves inhibition of IL-2 production.

Hamad AR, Mohamood AS, Trujillo CJ, Huang CT, Yuan E, Schneck JP.

J Immunol. 2003 Sep 1;171(5):2421-6.


IL-7R alpha gene expression is inversely correlated with cell cycle progression in IL-7-stimulated T lymphocytes.

Swainson L, Verhoeyen E, Cosset FL, Taylor N.

J Immunol. 2006 Jun 1;176(11):6702-8.


The production of IL-10 by human regulatory T cells is enhanced by IL-2 through a STAT5-responsive intronic enhancer in the IL-10 locus.

Tsuji-Takayama K, Suzuki M, Yamamoto M, Harashima A, Okochi A, Otani T, Inoue T, Sugimoto A, Toraya T, Takeuchi M, Yamasaki F, Nakamura S, Kibata M.

J Immunol. 2008 Sep 15;181(6):3897-905.


Inducing and expanding regulatory T cell populations by foreign antigen.

Kretschmer K, Apostolou I, Hawiger D, Khazaie K, Nussenzweig MC, von Boehmer H.

Nat Immunol. 2005 Dec;6(12):1219-27. Epub 2005 Oct 23.


Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen.

Knoechel B, Lohr J, Kahn E, Bluestone JA, Abbas AK.

J Exp Med. 2005 Nov 21;202(10):1375-86. Epub 2005 Nov 14.


Implications for gene therapy-limiting expression of IL-2R gamma c delineate differences in signaling thresholds required for lymphocyte development and maintenance.

Orr SJ, Roessler S, Quigley L, Chan T, Ford JW, O'Connor GM, McVicar DW.

J Immunol. 2010 Aug 1;185(3):1393-403. doi: 10.4049/jimmunol.0903528. Epub 2010 Jun 30.

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