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Items: 1 to 20 of 107

1.

Covalent binding of the organophosphorus agent FP-biotin to tyrosine in eight proteins that have no active site serine.

Grigoryan H, Li B, Anderson EK, Xue W, Nachon F, Lockridge O, Schopfer LM.

Chem Biol Interact. 2009 Aug 14;180(3):492-8. doi: 10.1016/j.cbi.2009.03.018. Epub 2009 Apr 2.

2.

Tyrosines of human and mouse transferrin covalently labeled by organophosphorus agents: a new motif for binding to proteins that have no active site serine.

Li B, Schopfer LM, Grigoryan H, Thompson CM, Hinrichs SH, Masson P, Lockridge O.

Toxicol Sci. 2009 Jan;107(1):144-55. doi: 10.1093/toxsci/kfn211. Epub 2008 Oct 16.

3.

Five tyrosines and two serines in human albumin are labeled by the organophosphorus agent FP-biotin.

Ding SJ, Carr J, Carlson JE, Tong L, Xue W, Li Y, Schopfer LM, Li B, Nachon F, Asojo O, Thompson CM, Hinrichs SH, Masson P, Lockridge O.

Chem Res Toxicol. 2008 Sep;21(9):1787-94. doi: 10.1021/tx800144z. Epub 2008 Aug 16.

4.

Characteristic mass spectral fragments of the organophosphorus agent FP-biotin and FP-biotinylated peptides from trypsin and bovine albumin (Tyr410).

Schopfer LM, Champion MM, Tamblyn N, Thompson CM, Lockridge O.

Anal Biochem. 2005 Oct 1;345(1):122-32.

PMID:
16125664
5.

Mass spectral characterization of organophosphate-labeled, tyrosine-containing peptides: characteristic mass fragments and a new binding motif for organophosphates.

Schopfer LM, Grigoryan H, Li B, Nachon F, Masson P, Lockridge O.

J Chromatogr B Analyt Technol Biomed Life Sci. 2010 May 15;878(17-18):1297-311. doi: 10.1016/j.jchromb.2009.07.026. Epub 2009 Jul 24.

6.

Mass spectrometry identifies covalent binding of soman, sarin, chlorpyrifos oxon, diisopropyl fluorophosphate, and FP-biotin to tyrosines on tubulin: a potential mechanism of long term toxicity by organophosphorus agents.

Grigoryan H, Schopfer LM, Thompson CM, Terry AV, Masson P, Lockridge O.

Chem Biol Interact. 2008 Sep 25;175(1-3):180-6. doi: 10.1016/j.cbi.2008.04.013. Epub 2008 Apr 22.

7.

Albumin, a new biomarker of organophosphorus toxicant exposure, identified by mass spectrometry.

Peeples ES, Schopfer LM, Duysen EG, Spaulding R, Voelker T, Thompson CM, Lockridge O.

Toxicol Sci. 2005 Feb;83(2):303-12. Epub 2004 Nov 3.

PMID:
15525694
8.

Mass spectral characterization of organophosphate-labeled lysine in peptides.

Grigoryan H, Li B, Xue W, Grigoryan M, Schopfer LM, Lockridge O.

Anal Biochem. 2009 Nov 1;394(1):92-100. doi: 10.1016/j.ab.2009.07.008. Epub 2009 Jul 9.

9.

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry assay for organophosphorus toxicants bound to human albumin at Tyr411.

Li B, Schopfer LM, Hinrichs SH, Masson P, Lockridge O.

Anal Biochem. 2007 Feb 15;361(2):263-72. Epub 2006 Dec 4.

10.

Mass spectrometry identifies multiple organophosphorylated sites on tubulin.

Grigoryan H, Schopfer LM, Peeples ES, Duysen EG, Grigoryan M, Thompson CM, Lockridge O.

Toxicol Appl Pharmacol. 2009 Oct 15;240(2):149-58. doi: 10.1016/j.taap.2009.07.020. Epub 2009 Jul 24.

11.

Cresyl saligenin phosphate, an organophosphorus toxicant, makes covalent adducts with histidine, lysine, and tyrosine residues of human serum albumin.

Liyasova MS, Schopfer LM, Lockridge O.

Chem Res Toxicol. 2012 Aug 20;25(8):1752-61. doi: 10.1021/tx300215g. Epub 2012 Jul 26.

12.

Review of tyrosine and lysine as new motifs for organophosphate binding to proteins that have no active site serine.

Lockridge O, Schopfer LM.

Chem Biol Interact. 2010 Sep 6;187(1-3):344-8. doi: 10.1016/j.cbi.2010.03.002. Epub 2010 Mar 6. Review.

13.

Nanoimages show disruption of tubulin polymerization by chlorpyrifos oxon: implications for neurotoxicity.

Grigoryan H, Lockridge O.

Toxicol Appl Pharmacol. 2009 Oct 15;240(2):143-8. doi: 10.1016/j.taap.2009.07.015. Epub 2009 Jul 22.

14.

PHOS-select iron affinity beads enrich peptides for the detection of organophosphorus adducts on albumin.

Jiang W, Dubrovskii YA, Podolskaya EP, Murashko EA, Babakov V, Nachon F, Masson P, Schopfer LM, Lockridge O.

Chem Res Toxicol. 2013 Dec 16;26(12):1917-25. doi: 10.1021/tx400352h. Epub 2013 Nov 14.

15.

Detection of adduct on tyrosine 411 of albumin in humans poisoned by dichlorvos.

Li B, Ricordel I, Schopfer LM, Baud F, Mégarbane B, Nachon F, Masson P, Lockridge O.

Toxicol Sci. 2010 Jul;116(1):23-31. doi: 10.1093/toxsci/kfq117. Epub 2010 Apr 15.

16.

Identification of new binding sites of human transferrin incubated with organophosphorus agents via Q Exactive LC-MS/MS.

Sun F, Ding J, Yu H, Gao R, Wang H, Pei C.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jun 1;1022:256-264. doi: 10.1016/j.jchromb.2016.04.028. Epub 2016 Apr 19.

PMID:
27128859
17.

Profiling serine hydrolase activities in complex proteomes.

Kidd D, Liu Y, Cravatt BF.

Biochemistry. 2001 Apr 3;40(13):4005-15.

PMID:
11300781
18.

Mice treated with a nontoxic dose of chlorpyrifos oxon have diethoxyphosphotyrosine labeled proteins in blood up to 4 days post exposure, detected by mass spectrometry.

Jiang W, Duysen EG, Lockridge O.

Toxicology. 2012 May 16;295(1-3):15-22. doi: 10.1016/j.tox.2012.03.001. Epub 2012 Mar 8.

PMID:
22406659
19.

Reaction kinetics of biotinylated organophosphorus toxicant, FP-biotin, with human acetylcholinesterase and human butyrylcholinesterase.

Schopfer LM, Voelker T, Bartels CF, Thompson CM, Lockridge O.

Chem Res Toxicol. 2005 Apr;18(4):747-54.

PMID:
15833035
20.

New insights on molecular interactions of organophosphorus pesticides with esterases.

Mangas I, Estevez J, Vilanova E, França TC.

Toxicology. 2017 Feb 1;376:30-43. doi: 10.1016/j.tox.2016.06.006. Epub 2016 Jun 14. Review.

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