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Items: 1 to 20 of 323

1.

The potent protein kinase C-selective inhibitor AEB071 (sotrastaurin) represents a new class of immunosuppressive agents affecting early T-cell activation.

Evenou JP, Wagner J, Zenke G, Brinkmann V, Wagner K, Kovarik J, Welzenbach KA, Weitz-Schmidt G, Guntermann C, Towbin H, Cottens S, Kaminski S, Letschka T, Lutz-Nicoladoni C, Gruber T, Hermann-Kleiter N, Thuille N, Baier G.

J Pharmacol Exp Ther. 2009 Sep;330(3):792-801. doi: 10.1124/jpet.109.153205. Epub 2009 Jun 2.

2.

Effects of the new immunosuppressive agent AEB071 on human immune cells.

Matz M, Weber U, Mashreghi MF, Lorkowski C, Ladhoff J, Kramer S, Neumayer HH, Budde K.

Nephrol Dial Transplant. 2010 Jul;25(7):2159-67. doi: 10.1093/ndt/gfp775. Epub 2010 Jan 25.

PMID:
20100729
3.

Differential roles of PKC-theta in the regulation of intracellular calcium concentration in primary T cells.

Manicassamy S, Sadim M, Ye RD, Sun Z.

J Mol Biol. 2006 Jan 20;355(3):347-59. Epub 2005 Nov 8.

PMID:
16309697
4.

Mechanistic study of saikosaponin-d (Ssd) on suppression of murine T lymphocyte activation.

Wong VK, Zhou H, Cheung SS, Li T, Liu L.

J Cell Biochem. 2009 May 15;107(2):303-15. doi: 10.1002/jcb.22126.

PMID:
19301261
5.

Protein kinase C-theta-mediated signals enhance CD4+ T cell survival by up-regulating Bcl-xL.

Manicassamy S, Gupta S, Huang Z, Sun Z.

J Immunol. 2006 Jun 1;176(11):6709-16.

6.

Blockade of T-cell activation by dithiocarbamates involves novel mechanisms of inhibition of nuclear factor of activated T cells.

Martínez-Martínez S, Gómez del Arco P, Armesilla AL, Aramburu J, Luo C, Rao A, Redondo JM.

Mol Cell Biol. 1997 Nov;17(11):6437-47.

7.

Filamin A is required for T cell activation mediated by protein kinase C-theta.

Hayashi K, Altman A.

J Immunol. 2006 Aug 1;177(3):1721-8.

9.

AEB071--a promising immunosuppressive agent.

Sommerer C, Zeier M.

Clin Transplant. 2009 Dec;23 Suppl 21:15-8. doi: 10.1111/j.1399-0012.2009.01104.x. Review.

PMID:
19930311
10.

Protein kinase C-theta (PKC theta): a key enzyme in T cell life and death.

Altman A, Villalba M.

J Biochem. 2002 Dec;132(6):841-6. Review.

11.

UR-1505, a new salicylate, blocks T cell activation through nuclear factor of activated T cells.

Román J, de Arriba AF, Barrón S, Michelena P, Giral M, Merlos M, Bailón E, Comalada M, Gálvez J, Zarzuelo A, Ramis I.

Mol Pharmacol. 2007 Aug;72(2):269-79. Epub 2007 May 2.

12.

Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes.

Wagner J, von Matt P, Sedrani R, Albert R, Cooke N, Ehrhardt C, Geiser M, Rummel G, Stark W, Strauss A, Cowan-Jacob SW, Beerli C, Weckbecker G, Evenou JP, Zenke G, Cottens S.

J Med Chem. 2009 Oct 22;52(20):6193-6. doi: 10.1021/jm901108b.

PMID:
19827831
13.

Protein kinase C inhibitor AEB071 targets ocular melanoma harboring GNAQ mutations via effects on the PKC/Erk1/2 and PKC/NF-κB pathways.

Wu X, Li J, Zhu M, Fletcher JA, Hodi FS.

Mol Cancer Ther. 2012 Sep;11(9):1905-14. doi: 10.1158/1535-7163.MCT-12-0121. Epub 2012 May 31.

15.

Overview of sotrastaurin clinical pharmacokinetics.

Kovarik JM, Slade A.

Ther Drug Monit. 2010 Oct;32(5):540-3. doi: 10.1097/FTD.0b013e3181ee9e26. Review.

PMID:
20683390
16.

Effects of the novel protein kinase C inhibitor AEB071 (Sotrastaurin) on rat cardiac allograft survival using single agent treatment or combination therapy with cyclosporine, everolimus or FTY720.

Weckbecker G, Pally C, Beerli C, Burkhart C, Wieczorek G, Metzler B, Morris RE, Wagner J, Bruns C.

Transpl Int. 2010 May 1;23(5):543-52. doi: 10.1111/j.1432-2277.2009.01015.x. Epub 2009 Dec 9.

17.

Characterization of TCR-induced phosphorylation of PKCtheta in primary murine lymphocytes.

Thebault S, Ochoa-Garay J.

Mol Immunol. 2004 Feb;40(13):931-42.

PMID:
14725789
18.

Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation.

Birchall AM, Bishop J, Bradshaw D, Cline A, Coffey J, Elliott LH, Gibson VM, Greenham A, Hallam TJ, Harris W, et al.

J Pharmacol Exp Ther. 1994 Feb;268(2):922-9.

PMID:
8114006
19.

CD28 stimulation triggers NF-kappaB activation through the CARMA1-PKCtheta-Grb2/Gads axis.

Takeda K, Harada Y, Watanabe R, Inutake Y, Ogawa S, Onuki K, Kagaya S, Tanabe K, Kishimoto H, Abe R.

Int Immunol. 2008 Dec;20(12):1507-15. doi: 10.1093/intimm/dxn108. Epub 2008 Oct 1.

PMID:
18829987
20.

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