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The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay.

Gehring NH, Lamprinaki S, Hentze MW, Kulozik AE.

PLoS Biol. 2009 May 26;7(5):e1000120. doi: 10.1371/journal.pbio.1000120. Epub 2009 May 26.


CWC22-dependent pre-mRNA splicing and eIF4A3 binding enables global deposition of exon junction complexes.

Steckelberg AL, Altmueller J, Dieterich C, Gehring NH.

Nucleic Acids Res. 2015 May 19;43(9):4687-700. doi: 10.1093/nar/gkv320. Epub 2015 Apr 13.


Transcriptome-wide modulation of splicing by the exon junction complex.

Wang Z, Murigneux V, Le Hir H.

Genome Biol. 2014;15(12):551.


Proteins associated with the exon junction complex also control the alternative splicing of apoptotic regulators.

Michelle L, Cloutier A, Toutant J, Shkreta L, Thibault P, Durand M, Garneau D, Gendron D, Lapointe E, Couture S, Le Hir H, Klinck R, Elela SA, Prinos P, Chabot B.

Mol Cell Biol. 2012 Mar;32(5):954-67. doi: 10.1128/MCB.06130-11. Epub 2011 Dec 27.


Perispeckles are major assembly sites for the exon junction core complex.

Daguenet E, Baguet A, Degot S, Schmidt U, Alpy F, Wendling C, Spiegelhalter C, Kessler P, Rio MC, Le Hir H, Bertrand E, Tomasetto C.

Mol Biol Cell. 2012 May;23(9):1765-82. doi: 10.1091/mbc.E12-01-0040. Epub 2012 Mar 14.


CWC22 connects pre-mRNA splicing and exon junction complex assembly.

Steckelberg AL, Boehm V, Gromadzka AM, Gehring NH.

Cell Rep. 2012 Sep 27;2(3):454-61. doi: 10.1016/j.celrep.2012.08.017. Epub 2012 Sep 6.


Human CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly.

Barbosa I, Haque N, Fiorini F, Barrandon C, Tomasetto C, Blanchette M, Le Hir H.

Nat Struct Mol Biol. 2012 Oct;19(10):983-90. doi: 10.1038/nsmb.2380. Epub 2012 Sep 9.


Human spliceosomal protein CWC22 plays a role in coupling splicing to exon junction complex deposition and nonsense-mediated decay.

Alexandrov A, Colognori D, Shu MD, Steitz JA.

Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21313-8. doi: 10.1073/pnas.1219725110. Epub 2012 Dec 10.


Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay.

Singh KK, Wachsmuth L, Kulozik AE, Gehring NH.

RNA Biol. 2013 Aug;10(8):1291-8. doi: 10.4161/rna.25827. Epub 2013 Jul 23.


eIF4A3 is a novel component of the exon junction complex.

Chan CC, Dostie J, Diem MD, Feng W, Mann M, Rappsilber J, Dreyfuss G.

RNA. 2004 Feb;10(2):200-9.


Association of the breast cancer protein MLN51 with the exon junction complex via its speckle localizer and RNA binding module.

Degot S, Le Hir H, Alpy F, Kedinger V, Stoll I, Wendling C, Seraphin B, Rio MC, Tomasetto C.

J Biol Chem. 2004 Aug 6;279(32):33702-15. Epub 2004 May 27.


eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay.

Shibuya T, Tange TØ, Sonenberg N, Moore MJ.

Nat Struct Mol Biol. 2004 Apr;11(4):346-51. Epub 2004 Mar 21.


Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.

Tange TØ, Shibuya T, Jurica MS, Moore MJ.

RNA. 2005 Dec;11(12):1869-83.


Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay.

Kashima I, Yamashita A, Izumi N, Kataoka N, Morishita R, Hoshino S, Ohno M, Dreyfuss G, Ohno S.

Genes Dev. 2006 Feb 1;20(3):355-67.


The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity.

Ballut L, Marchadier B, Baguet A, Tomasetto C, Séraphin B, Le Hir H.

Nat Struct Mol Biol. 2005 Oct;12(10):861-9. Epub 2005 Sep 18.


Structure of the Y14-Magoh core of the exon junction complex.

Lau CK, Diem MD, Dreyfuss G, Van Duyne GD.

Curr Biol. 2003 May 27;13(11):933-41.

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