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Items: 1 to 20 of 122

1.

PARP-1 inhibition-induced activation of PI-3-kinase-Akt pathway promotes resistance to taxol.

Szanto A, Hellebrand EE, Bognar Z, Tucsek Z, Szabo A, Gallyas F Jr, Sumegi B, Varbiro G.

Biochem Pharmacol. 2009 Apr 15;77(8):1348-57. doi: 10.1016/j.bcp.2009.01.008. Epub 2009 Jan 24.

PMID:
19426673
2.

Pivotal role of Akt activation in mitochondrial protection and cell survival by poly(ADP-ribose)polymerase-1 inhibition in oxidative stress.

Tapodi A, Debreceni B, Hanto K, Bognar Z, Wittmann I, Gallyas F Jr, Varbiro G, Sumegi B.

J Biol Chem. 2005 Oct 21;280(42):35767-75. Epub 2005 Aug 22.

3.

Critical role of PI3-kinase/Akt activation in the PARP inhibitor induced heart function recovery during ischemia-reperfusion.

Kovacs K, Toth A, Deres P, Kalai T, Hideg K, Gallyas F Jr, Sumegi B.

Biochem Pharmacol. 2006 Feb 14;71(4):441-52. Epub 2005 Dec 6.

PMID:
16337154
4.

PARP inhibition attenuates acute kidney allograft rejection by suppressing cell death pathways and activating PI-3K-Akt cascade.

Kalmar-Nagy K, Degrell P, Szabo A, Sumegi K, Wittmann I, Gallyas F Jr, Sumegi B.

PLoS One. 2013 Dec 3;8(12):e81928. doi: 10.1371/journal.pone.0081928. eCollection 2013.

6.

Taxol induces caspase-10-dependent apoptosis.

Park SJ, Wu CH, Gordon JD, Zhong X, Emami A, Safa AR.

J Biol Chem. 2004 Dec 3;279(49):51057-67. Epub 2004 Sep 27.

7.

Critical role of bad phosphorylation by Akt in cytostatic resistance of human bladder cancer cells.

Szanto A, Bognar Z, Szigeti A, Szabo A, Farkas L, Gallyas F Jr.

Anticancer Res. 2009 Jan;29(1):159-64.

9.

Knockdown of DEPTOR inhibits cell proliferation and increases chemosensitivity to melphalan in human multiple myeloma RPMI-8226 cells via inhibiting PI3K/AKT activity.

Zhang HR, Chen JM, Zeng ZY, Que WZ.

J Int Med Res. 2013 Jun;41(3):584-95. doi: 10.1177/0300060513480920. Epub 2013 Apr 15.

PMID:
23613505
10.
11.

Protective effect of the poly(ADP-ribose) polymerase inhibitor PJ34 on mitochondrial depolarization-mediated cell death in hepatocellular carcinoma cells involves attenuation of c-Jun N-terminal kinase-2 and protein kinase B/Akt activation.

Radnai B, Antus C, Racz B, Engelmann P, Priber JK, Tucsek Z, Veres B, Turi Z, Lorand T, Sumegi B, Gallyas F Jr.

Mol Cancer. 2012 May 14;11:34. doi: 10.1186/1476-4598-11-34.

12.
13.

Herbacetin induces apoptosis in HepG2 cells: Involvements of ROS and PI3K/Akt pathway.

Qiao Y, Xiang Q, Yuan L, Xu L, Liu Z, Liu X.

Food Chem Toxicol. 2013 Jan;51:426-33. doi: 10.1016/j.fct.2012.09.036. Epub 2012 Oct 12.

PMID:
23063593
14.
15.

Silencing dishevelled-1 sensitizes paclitaxel-resistant human ovarian cancer cells via AKT/GSK-3β/β-catenin signalling.

Zhang K, Song H, Yang P, Dai X, Li Y, Wang L, Du J, Pan K, Zhang T.

Cell Prolif. 2015 Apr;48(2):249-58. doi: 10.1111/cpr.12161. Epub 2015 Jan 21.

PMID:
25643607
17.
18.

The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism.

Chiarini F, Del Sole M, Mongiorgi S, Gaboardi GC, Cappellini A, Mantovani I, Follo MY, McCubrey JA, Martelli AM.

Leukemia. 2008 Jun;22(6):1106-16. doi: 10.1038/leu.2008.79. Epub 2008 Apr 3.

PMID:
18385752
19.

PARP inhibition restores extrinsic apoptotic sensitivity in glioblastoma.

Karpel-Massler G, Pareja F, Aimé P, Shu C, Chau L, Westhoff MA, Halatsch ME, Crary JF, Canoll P, Siegelin MD.

PLoS One. 2014 Dec 22;9(12):e114583. doi: 10.1371/journal.pone.0114583. eCollection 2014.

20.

A quinazoline-derivative compound with PARP inhibitory effect suppresses hypertension-induced vascular alterations in spontaneously hypertensive rats.

Magyar K, Deres L, Eros K, Bruszt K, Seress L, Hamar J, Hideg K, Balogh A, Gallyas F Jr, Sumegi B, Toth K, Halmosi R.

Biochim Biophys Acta. 2014 Jul;1842(7):935-44. doi: 10.1016/j.bbadis.2014.03.008. Epub 2014 Mar 19.

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