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FANCJ helicase uniquely senses oxidative base damage in either strand of duplex DNA and is stimulated by replication protein A to unwind the damaged DNA substrate in a strand-specific manner.

Suhasini AN, Sommers JA, Mason AC, Voloshin ON, Camerini-Otero RD, Wold MS, Brosh RM Jr.

J Biol Chem. 2009 Jul 3;284(27):18458-70. doi: 10.1074/jbc.M109.012229. Epub 2009 May 5.


Novel function of the Fanconi anemia group J or RECQ1 helicase to disrupt protein-DNA complexes in a replication protein A-stimulated manner.

Sommers JA, Banerjee T, Hinds T, Wan B, Wold MS, Lei M, Brosh RM Jr.

J Biol Chem. 2014 Jul 18;289(29):19928-41. doi: 10.1074/jbc.M113.542456. Epub 2014 Jun 3.


FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability.

Wu Y, Shin-ya K, Brosh RM Jr.

Mol Cell Biol. 2008 Jun;28(12):4116-28. doi: 10.1128/MCB.02210-07. Epub 2008 Apr 21.


Impact of age-associated cyclopurine lesions on DNA repair helicases.

Khan I, Suhasini AN, Banerjee T, Sommers JA, Kaplan DL, Kuper J, Kisker C, Brosh RM Jr.

PLoS One. 2014 Nov 19;9(11):e113293. doi: 10.1371/journal.pone.0113293. eCollection 2014.


Insight into the roles of helicase motif Ia by characterizing Fanconi anemia group J protein (FANCJ) patient mutations.

Guo M, Vidhyasagar V, Ding H, Wu Y.

J Biol Chem. 2014 Apr 11;289(15):10551-65. doi: 10.1074/jbc.M113.538892. Epub 2014 Feb 25.


Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome.

Suhasini AN, Rawtani NA, Wu Y, Sommers JA, Sharma S, Mosedale G, North PS, Cantor SB, Hickson ID, Brosh RM Jr.

EMBO J. 2011 Feb 16;30(4):692-705. doi: 10.1038/emboj.2010.362. Epub 2011 Jan 14.


Inhibition of BACH1 (FANCJ) helicase by backbone discontinuity is overcome by increased motor ATPase or length of loading strand.

Gupta R, Sharma S, Doherty KM, Sommers JA, Cantor SB, Brosh RM Jr.

Nucleic Acids Res. 2006;34(22):6673-83. Epub 2006 Dec 1.


Specialization among iron-sulfur cluster helicases to resolve G-quadruplex DNA structures that threaten genomic stability.

Bharti SK, Sommers JA, George F, Kuper J, Hamon F, Shin-ya K, Teulade-Fichou MP, Kisker C, Brosh RM Jr.

J Biol Chem. 2013 Sep 27;288(39):28217-29. doi: 10.1074/jbc.M113.496463. Epub 2013 Aug 9.


FANCJ uses its motor ATPase to destabilize protein-DNA complexes, unwind triplexes, and inhibit RAD51 strand exchange.

Sommers JA, Rawtani N, Gupta R, Bugreev DV, Mazin AV, Cantor SB, Brosh RM Jr.

J Biol Chem. 2009 Mar 20;284(12):7505-17. doi: 10.1074/jbc.M809019200. Epub 2009 Jan 16.


Fanconi anemia group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes.

Wu Y, Sommers JA, Suhasini AN, Leonard T, Deakyne JS, Mazin AV, Shin-Ya K, Kitao H, Brosh RM Jr.

Blood. 2010 Nov 11;116(19):3780-91. doi: 10.1182/blood-2009-11-256016. Epub 2010 Jul 16.


Biochemical characterization of Warsaw breakage syndrome helicase.

Wu Y, Sommers JA, Khan I, de Winter JP, Brosh RM Jr.

J Biol Chem. 2012 Jan 6;287(2):1007-21. doi: 10.1074/jbc.M111.276022. Epub 2011 Nov 18.


Inhibition of Werner syndrome helicase activity by benzo[a]pyrene diol epoxide adducts can be overcome by replication protein A.

Choudhary S, Doherty KM, Handy CJ, Sayer JM, Yagi H, Jerina DM, Brosh RM Jr.

J Biol Chem. 2006 Mar 3;281(9):6000-9. Epub 2005 Dec 27.


Fanconi anemia and Bloom's syndrome crosstalk through FANCJ-BLM helicase interaction.

Suhasini AN, Brosh RM Jr.

Trends Genet. 2012 Jan;28(1):7-13. doi: 10.1016/j.tig.2011.09.003. Epub 2011 Oct 23.


Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicases.

Doherty KM, Sommers JA, Gray MD, Lee JW, von Kobbe C, Thoma NH, Kureekattil RP, Kenny MK, Brosh RM Jr.

J Biol Chem. 2005 Aug 19;280(33):29494-505. Epub 2005 Jun 17.


A distinct triplex DNA unwinding activity of ChlR1 helicase.

Guo M, Hundseth K, Ding H, Vidhyasagar V, Inoue A, Nguyen CH, Zain R, Lee JS, Wu Y.

J Biol Chem. 2015 Feb 20;290(8):5174-89. doi: 10.1074/jbc.M114.634923. Epub 2015 Jan 5.


FANCJ suppresses microsatellite instability and lymphomagenesis independent of the Fanconi anemia pathway.

Matsuzaki K, Borel V, Adelman CA, Schindler D, Boulton SJ.

Genes Dev. 2015 Dec 15;29(24):2532-46. doi: 10.1101/gad.272740.115. Epub 2015 Dec 4.


DNA repair and replication fork helicases are differentially affected by alkyl phosphotriester lesion.

Suhasini AN, Sommers JA, Yu S, Wu Y, Xu T, Kelman Z, Kaplan DL, Brosh RM Jr.

J Biol Chem. 2012 Jun 1;287(23):19188-98. doi: 10.1074/jbc.M112.352757. Epub 2012 Apr 12.


Fanconi anemia group J helicase and MRE11 nuclease interact to facilitate the DNA damage response.

Suhasini AN, Sommers JA, Muniandy PA, Coulombe Y, Cantor SB, Masson JY, Seidman MM, Brosh RM Jr.

Mol Cell Biol. 2013 Jun;33(11):2212-27. doi: 10.1128/MCB.01256-12. Epub 2013 Mar 25.

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