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Items: 1 to 20 of 123

1.

Germ cell migration in zebrafish is cyclopamine-sensitive but Smoothened-independent.

Mich JK, Blaser H, Thomas NA, Firestone AJ, Yelon D, Raz E, Chen JK.

Dev Biol. 2009 Apr 15;328(2):342-54. doi: 10.1016/j.ydbio.2009.01.036. Epub 2009 Feb 4.

2.

Hedgehog signaling is required for differentiation of endocardial progenitors in zebrafish.

Wong KS, Rehn K, Palencia-Desai S, Kohli V, Hunter W, Uhl JD, Rost MS, Sumanas S.

Dev Biol. 2012 Jan 15;361(2):377-91. doi: 10.1016/j.ydbio.2011.11.004. Epub 2011 Nov 12.

3.

Impact of the Smoothened inhibitor, IPI-926, on smoothened ciliary localization and Hedgehog pathway activity.

Peluso MO, Campbell VT, Harari JA, Tibbitts TT, Proctor JL, Whitebread N, Conley JM, White KF, Kutok JL, Read MA, McGovern K, Faia KL.

PLoS One. 2014 Mar 7;9(3):e90534. doi: 10.1371/journal.pone.0090534. eCollection 2014.

4.

Effects of inhibition of hedgehog signaling on cell growth and migration of uveal melanoma cells.

Duan F, Lin M, Li C, Ding X, Qian G, Zhang H, Ge S, Fan X, Li J.

Cancer Biol Ther. 2014 May;15(5):544-59. doi: 10.4161/cbt.28157. Epub 2014 Mar 11.

5.

Vertebrate Smoothened functions at the primary cilium.

Corbit KC, Aanstad P, Singla V, Norman AR, Stainier DY, Reiter JF.

Nature. 2005 Oct 13;437(7061):1018-21. Epub 2005 Aug 31.

PMID:
16136078
6.

Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion.

Bijlsma MF, Spek CA, Zivkovic D, van de Water S, Rezaee F, Peppelenbosch MP.

PLoS Biol. 2006 Jul;4(8):e232.

7.

Paracrine insulin-like growth factor signaling influences primordial germ cell migration: in vivo evidence from the zebrafish model.

Sang X, Curran MS, Wood AW.

Endocrinology. 2008 Oct;149(10):5035-42. doi: 10.1210/en.2008-0534. Epub 2008 Jun 19.

PMID:
18566124
8.

Zebrafish Staufen1 and Staufen2 are required for the survival and migration of primordial germ cells.

Ramasamy S, Wang H, Quach HN, Sampath K.

Dev Biol. 2006 Apr 15;292(2):393-406. Epub 2006 Mar 2.

9.

Insulin-like growth factor receptor 1b is required for zebrafish primordial germ cell migration and survival.

Schlueter PJ, Sang X, Duan C, Wood AW.

Dev Biol. 2007 May 1;305(1):377-87. Epub 2007 Feb 21.

10.

Gβγ signaling controls the polarization of zebrafish primordial germ cells by regulating Rac activity.

Xu H, Kardash E, Chen S, Raz E, Lin F.

Development. 2012 Jan;139(1):57-62. doi: 10.1242/dev.073924. Epub 2011 Nov 17.

11.

Roles of Hedgehog pathway components and retinoic acid signalling in specifying zebrafish ventral spinal cord neurons.

England S, Batista MF, Mich JK, Chen JK, Lewis KE.

Development. 2011 Dec;138(23):5121-34. doi: 10.1242/dev.066159.

12.

The extracellular domain of Smoothened regulates ciliary localization and is required for high-level Hh signaling.

Aanstad P, Santos N, Corbit KC, Scherz PJ, Trinh le A, Salvenmoser W, Huisken J, Reiter JF, Stainier DY.

Curr Biol. 2009 Jun 23;19(12):1034-9. doi: 10.1016/j.cub.2009.04.053. Epub 2009 May 21.

13.

Hedgehog signaling is required at multiple stages of zebrafish tooth development.

Jackman WR, Yoo JJ, Stock DW.

BMC Dev Biol. 2010 Nov 30;10:119. doi: 10.1186/1471-213X-10-119.

14.

Tumor shrinkage by cyclopamine tartrate through inhibiting hedgehog signaling.

Fan Q, Gu D, He M, Liu H, Sheng T, Xie G, Li CX, Zhang X, Wainwright B, Garrossian A, Garrossian M, Gardner D, Xie J.

Chin J Cancer. 2011 Jul;30(7):472-81. doi: 10.5732/cjc.011.10157.

15.

Hhip regulates zebrafish muscle development by both sequestering Hedgehog and modulating localization of Smoothened.

Ochi H, Pearson BJ, Chuang PT, Hammerschmidt M, Westerfield M.

Dev Biol. 2006 Sep 1;297(1):127-40. Epub 2006 May 6.

16.

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine.

Taipale J, Chen JK, Cooper MK, Wang B, Mann RK, Milenkovic L, Scott MP, Beachy PA.

Nature. 2000 Aug 31;406(6799):1005-9.

PMID:
10984056
17.

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists.

Frank-Kamenetsky M, Zhang XM, Bottega S, Guicherit O, Wichterle H, Dudek H, Bumcrot D, Wang FY, Jones S, Shulok J, Rubin LL, Porter JA.

J Biol. 2002 Nov 6;1(2):10.

18.

Cyclopamine inhibition of human breast cancer cell growth independent of Smoothened (Smo).

Zhang X, Harrington N, Moraes RC, Wu MF, Hilsenbeck SG, Lewis MT.

Breast Cancer Res Treat. 2009 Jun;115(3):505-21. doi: 10.1007/s10549-008-0093-3. Epub 2008 Jun 19.

19.

Cyclopamine did not affect mouse oocyte maturation in vitro but decreased early embryonic development.

Liu Y, Wei Z, Huang Y, Bai C, Zan L, Li G.

Anim Sci J. 2014 Sep;85(9):840-7. doi: 10.1111/asj.12220. Epub 2014 Jun 3.

PMID:
24889396
20.

Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation.

Wang Y, Zhou Z, Walsh CT, McMahon AP.

Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2623-8. doi: 10.1073/pnas.0812110106. Epub 2009 Feb 5.

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