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Items: 1 to 20 of 528

1.

KLYP956 is a non-imidazole-based orally active inhibitor of nitric-oxide synthase dimerization.

Symons KT, Massari ME, Nguyen PM, Lee TT, Roppe J, Bonnefous C, Payne JE, Smith ND, Noble SA, Sablad M, Rozenkrants N, Zhang Y, Rao TS, Shiau AK, Hassig CA.

Mol Pharmacol. 2009 Jul;76(1):153-62. doi: 10.1124/mol.109.055434. Epub 2009 Apr 13.

2.

Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models.

Bonnefous C, Payne JE, Roppe J, Zhuang H, Chen X, Symons KT, Nguyen PM, Sablad M, Rozenkrants N, Zhang Y, Wang L, Severance D, Walsh JP, Yazdani N, Shiau AK, Noble SA, Rix P, Rao TS, Hassig CA, Smith ND.

J Med Chem. 2009 May 14;52(9):3047-62. doi: 10.1021/jm900173b.

PMID:
19374401
3.
4.

Mechanistic studies with potent and selective inducible nitric-oxide synthase dimerization inhibitors.

Blasko E, Glaser CB, Devlin JJ, Xia W, Feldman RI, Polokoff MA, Phillips GB, Whitlow M, Auld DS, McMillan K, Ghosh S, Stuehr DJ, Parkinson JF.

J Biol Chem. 2002 Jan 4;277(1):295-302. Epub 2001 Oct 31.

5.

Allosteric inhibitors of inducible nitric oxide synthase dimerization discovered via combinatorial chemistry.

McMillan K, Adler M, Auld DS, Baldwin JJ, Blasko E, Browne LJ, Chelsky D, Davey D, Dolle RE, Eagen KA, Erickson S, Feldman RI, Glaser CB, Mallari C, Morrissey MM, Ohlmeyer MH, Pan G, Parkinson JF, Phillips GB, Polokoff MA, Sigal NH, Vergona R, Whitlow M, Young TA, Devlin JJ.

Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1506-11.

6.

Pharmacological characterization of KLYP961, a dual inhibitor of inducible and neuronal nitric-oxide synthases.

Symons KT, Nguyen PM, Massari ME, Anzola JV, Staszewski LM, Wang L, Yazdani N, Dorow S, Muhammad J, Sablad M, Rozenkrants N, Bonefous C, Payne JE, Rix PJ, Shiau AK, Noble SA, Smith ND, Hassig CA, Zhang Y, Rao TS.

J Pharmacol Exp Ther. 2011 Feb;336(2):468-78. doi: 10.1124/jpet.110.172817. Epub 2010 Oct 29.

7.

Structures of the N(omega)-hydroxy-L-arginine complex of inducible nitric oxide synthase oxygenase dimer with active and inactive pterins.

Crane BR, Arvai AS, Ghosh S, Getzoff ED, Stuehr DJ, Tainer JA.

Biochemistry. 2000 Apr 25;39(16):4608-21.

PMID:
10769116
8.

Structure-activity relationships of 2-aminothiazole derivatives as inducible nitric oxide synthase inhibitor.

Ueda S, Terauchi H, Kawasaki M, Yano A, Ido M.

Chem Pharm Bull (Tokyo). 2004 May;52(5):634-7.

9.

Kalirin inhibition of inducible nitric-oxide synthase.

Ratovitski EA, Alam MR, Quick RA, McMillan A, Bao C, Kozlovsky C, Hand TA, Johnson RC, Mains RE, Eipper BA, Lowenstein CJ.

J Biol Chem. 1999 Jan 8;274(2):993-9.

10.

Formation of nitric oxide synthase-iron(II) nitrosoalkane complexes: severe restriction of access to the iron(II) site in the presence of tetrahydrobiopterin.

Renodon A, Boucher JL, Wu C, Gachhui R, Sari MA, Mansuy D, Stuehr D.

Biochemistry. 1998 May 5;37(18):6367-74.

PMID:
9572852
11.
12.

Cyclo(dehydrohistidyl-l-tryptophyl) inhibits nitric oxide production by preventing the dimerization of inducible nitric oxide synthase.

Sohn MJ, Hur GM, Byun HS, Kim WG.

Biochem Pharmacol. 2008 Feb 15;75(4):923-30. Epub 2007 Oct 24.

PMID:
18061143
13.

A tryptophan that modulates tetrahydrobiopterin-dependent electron transfer in nitric oxide synthase regulates enzyme catalysis by additional mechanisms.

Wang ZQ, Wei CC, Santolini J, Panda K, Wang Q, Stuehr DJ.

Biochemistry. 2005 Mar 29;44(12):4676-90.

PMID:
15779894
14.

Structural requirements for inhibition of the neuronal nitric oxide synthase (NOS-I): 3D-QSAR analysis of 4-oxo- and 4-amino-pteridine-based inhibitors.

Matter H, Kotsonis P, Klingler O, Strobel H, Fröhlich LG, Frey A, Pfleiderer W, Schmidt HH.

J Med Chem. 2002 Jul 4;45(14):2923-41.

PMID:
12086480
15.

Pharmacological interference with dimerization of human neuronal nitric-oxide synthase expressed in adenovirus-infected DLD-1 cells.

Habisch HJ, Gorren AC, Liang H, Venema RC, Parkinson JF, Schmidt K, Mayer B.

Mol Pharmacol. 2003 Mar;63(3):682-9.

16.

Control of nitric oxide synthase dimer assembly by a heme-NO-dependent mechanism.

Chen Y, Panda K, Stuehr DJ.

Biochemistry. 2002 Apr 9;41(14):4618-25.

PMID:
11926824
17.
18.

An inducible nitric-oxide synthase (NOS)-associated protein inhibits NOS dimerization and activity.

Ratovitski EA, Bao C, Quick RA, McMillan A, Kozlovsky C, Lowenstein CJ.

J Biol Chem. 1999 Oct 15;274(42):30250-7.

19.

Antifungal imidazoles block assembly of inducible NO synthase into an active dimer.

Sennequier N, Wolan D, Stuehr DJ.

J Biol Chem. 1999 Jan 8;274(2):930-8.

20.

Synthesis and evaluation of new sulfur-containing L-arginine-derived inhibitors of nitric oxide synthase.

Ichimori K, Stuehr DJ, Atkinson RN, King SB.

J Med Chem. 1999 May 20;42(10):1842-8.

PMID:
10346937

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