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Analysis of activator-binding sites on the APC/C supports a cooperative substrate-binding mechanism.

Matyskiela ME, Morgan DO.

Mol Cell. 2009 Apr 10;34(1):68-80. doi: 10.1016/j.molcel.2009.02.027.


The APC/C: a smörgåsbord for proteolysis.

Pines J.

Mol Cell. 2009 Apr 24;34(2):135-6. doi: 10.1016/j.molcel.2009.04.006.


Structures of APC/C(Cdh1) with substrates identify Cdh1 and Apc10 as the D-box co-receptor.

da Fonseca PC, Kong EH, Zhang Z, Schreiber A, Williams MA, Morris EP, Barford D.

Nature. 2011 Feb 10;470(7333):274-8. doi: 10.1038/nature09625. Epub 2010 Nov 24.


An architectural map of the anaphase-promoting complex.

Thornton BR, Ng TM, Matyskiela ME, Carroll CW, Morgan DO, Toczyski DP.

Genes Dev. 2006 Feb 15;20(4):449-60.


Structural basis for the subunit assembly of the anaphase-promoting complex.

Schreiber A, Stengel F, Zhang Z, Enchev RI, Kong EH, Morris EP, Robinson CV, da Fonseca PC, Barford D.

Nature. 2011 Feb 10;470(7333):227-32. doi: 10.1038/nature09756.


Roles of the anaphase-promoting complex/cyclosome and of its activator Cdc20 in functional substrate binding.

Eytan E, Moshe Y, Braunstein I, Hershko A.

Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2081-6. Epub 2006 Feb 2. Erratum in: Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5242.


Substrate binding on the APC/C occurs between the coactivator Cdh1 and the processivity factor Doc1.

Buschhorn BA, Petzold G, Galova M, Dube P, Kraft C, Herzog F, Stark H, Peters JM.

Nat Struct Mol Biol. 2011 Jan;18(1):6-13. doi: 10.1038/nsmb.1979. Epub 2010 Dec 26.


TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1.

Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM.

Curr Biol. 2003 Sep 2;13(17):1459-68.


The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substrates.

Kraft C, Vodermaier HC, Maurer-Stroh S, Eisenhaber F, Peters JM.

Mol Cell. 2005 May 27;18(5):543-53.


Hsl1p, a Swe1p inhibitor, is degraded via the anaphase-promoting complex.

Burton JL, Solomon MJ.

Mol Cell Biol. 2000 Jul;20(13):4614-25.


Pseudosubstrate inhibition of the anaphase-promoting complex by Acm1: regulation by proteolysis and Cdc28 phosphorylation.

Ostapenko D, Burton JL, Wang R, Solomon MJ.

Mol Cell Biol. 2008 Aug;28(15):4653-64. doi: 10.1128/MCB.00055-08. Epub 2008 Jun 2.


Ubiquitination of Cdc20 by the APC occurs through an intramolecular mechanism.

Foe IT, Foster SA, Cheung SK, DeLuca SZ, Morgan DO, Toczyski DP.

Curr Biol. 2011 Nov 22;21(22):1870-7. doi: 10.1016/j.cub.2011.09.051. Epub 2011 Nov 10.


Insights into the cellular mechanism of the yeast ubiquitin ligase APC/C-Cdh1 from the analysis of in vivo degrons.

Arnold L, Höckner S, Seufert W.

Mol Biol Cell. 2015 Mar 1;26(5):843-58. doi: 10.1091/mbc.E14-09-1342. Epub 2014 Dec 24.


Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex.

Pfleger CM, Lee E, Kirschner MW.

Genes Dev. 2001 Sep 15;15(18):2396-407.


Yeast Hct1 recognizes the mitotic cyclin Clb2 and other substrates of the ubiquitin ligase APC.

Schwab M, Neutzner M, Möcker D, Seufert W.

EMBO J. 2001 Sep 17;20(18):5165-75.

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