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PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis.

Huang X, Venet F, Wang YL, Lepape A, Yuan Z, Chen Y, Swan R, Kherouf H, Monneret G, Chung CS, Ayala A.

Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6303-8. doi: 10.1073/pnas.0809422106. Epub 2009 Mar 30.


Identification of B7-H1 as a novel mediator of the innate immune/proinflammatory response as well as a possible myeloid cell prognostic biomarker in sepsis.

Huang X, Chen Y, Chung CS, Yuan Z, Monaghan SF, Wang F, Ayala A.

J Immunol. 2014 Feb 1;192(3):1091-9. doi: 10.4049/jimmunol.1302252. Epub 2013 Dec 30.


B7-H3 augments the inflammatory response and is associated with human sepsis.

Zhang G, Wang J, Kelly J, Gu G, Hou J, Zhou Y, Redmond HP, Wang JH, Zhang X.

J Immunol. 2010 Sep 15;185(6):3677-84. doi: 10.4049/jimmunol.0904020. Epub 2010 Aug 9.


Upregulation of programmed death-1 on T cells and programmed death ligand-1 on monocytes in septic shock patients.

Zhang Y, Li J, Lou J, Zhou Y, Bo L, Zhu J, Zhu K, Wan X, Cai Z, Deng X.

Crit Care. 2011;15(1):R70. doi: 10.1186/cc10059. Epub 2011 Feb 24.


Inflammatory mechanisms in sepsis: elevated invariant natural killer T-cell numbers in mouse and their modulatory effect on macrophage function.

Heffernan DS, Monaghan SF, Thakkar RK, Tran ML, Chung CS, Gregory SH, Cioffi WG, Ayala A.

Shock. 2013 Aug;40(2):122-8. doi: 10.1097/SHK.0b013e31829ca519.


Loss of the oxygen sensor PHD3 enhances the innate immune response to abdominal sepsis.

Kiss J, Mollenhauer M, Walmsley SR, Kirchberg J, Radhakrishnan P, Niemietz T, Dudda J, Steinert G, Whyte MK, Carmeliet P, Mazzone M, Weitz J, Schneider M.

J Immunol. 2012 Aug 15;189(4):1955-65. doi: 10.4049/jimmunol.1103471. Epub 2012 Jul 11.


BTLA expression contributes to septic morbidity and mortality by inducing innate inflammatory cell dysfunction.

Shubin NJ, Chung CS, Heffernan DS, Irwin LR, Monaghan SF, Ayala A.

J Leukoc Biol. 2012 Sep;92(3):593-603. doi: 10.1189/jlb.1211641. Epub 2012 Mar 29.


Sepsis-induced potentiation of peritoneal macrophage migration is mitigated by programmed cell death receptor-1 gene deficiency.

Ayala A, Elphick GF, Kim YS, Huang X, Carreira-Rosario A, Santos SC, Shubin NJ, Chen Y, Reichner J, Chung CS.

J Innate Immun. 2014;6(3):325-38. doi: 10.1159/000355888. Epub 2013 Nov 16.


Interleukin 5 is protective during sepsis in an eosinophil-independent manner.

Linch SN, Danielson ET, Kelly AM, Tamakawa RA, Lee JJ, Gold JA.

Am J Respir Crit Care Med. 2012 Aug 1;186(3):246-54. doi: 10.1164/rccm.201201-0134OC. Epub 2012 May 31.


Sepsis-induced changes in macrophage co-stimulatory molecule expression: CD86 as a regulator of anti-inflammatory IL-10 response.

Newton S, Ding Y, Chung CS, Chen Y, Lomas-Neira JL, Ayala A.

Surg Infect (Larchmt). 2004 Winter;5(4):375-83.


Macrophage migration inhibitory factor and host innate immune defenses against bacterial sepsis.

Calandra T, Froidevaux C, Martin C, Roger T.

J Infect Dis. 2003 Jun 15;187 Suppl 2:S385-90.


CCR1 and CC chemokine ligand 5 interactions exacerbate innate immune responses during sepsis.

Ness TL, Carpenter KJ, Ewing JL, Gerard CJ, Hogaboam CM, Kunkel SL.

J Immunol. 2004 Dec 1;173(11):6938-48.


Macrophage migration inhibitory factor and innate immune responses to bacterial infections.

Froidevaux C, Roger T, Martin C, Glauser MP, Calandra T.

Crit Care Med. 2001 Jul;29(7 Suppl):S13-5. Review.


PD-1 negatively regulates interleukin-12 expression by limiting STAT-1 phosphorylation in monocytes/macrophages during chronic hepatitis C virus infection.

Ma CJ, Ni L, Zhang Y, Zhang CL, Wu XY, Atia AN, Thayer P, Moorman JP, Yao ZQ.

Immunology. 2011 Mar;132(3):421-31. doi: 10.1111/j.1365-2567.2010.03382.x. Epub 2010 Nov 23.


PD-1 on dendritic cells impedes innate immunity against bacterial infection.

Yao S, Wang S, Zhu Y, Luo L, Zhu G, Flies S, Xu H, Ruff W, Broadwater M, Choi IH, Tamada K, Chen L.

Blood. 2009 Jun 4;113(23):5811-8. doi: 10.1182/blood-2009-02-203141. Epub 2009 Apr 1.


Thrombospondin-1 contributes to mortality in murine sepsis through effects on innate immunity.

McMaken S, Exline MC, Mehta P, Piper M, Wang Y, Fischer SN, Newland CA, Schrader CA, Balser SR, Sarkar A, Baran CP, Marsh CB, Cook CH, Phillips GS, Ali NA.

PLoS One. 2011 May 9;6(5):e19654. doi: 10.1371/journal.pone.0019654.


Aberrant inflammation and lethality to septic peritonitis in mice lacking STAT3 in macrophages and neutrophils.

Matsukawa A, Takeda K, Kudo S, Maeda T, Kagayama M, Akira S.

J Immunol. 2003 Dec 1;171(11):6198-205.


Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis.

Brahmamdam P, Inoue S, Unsinger J, Chang KC, McDunn JE, Hotchkiss RS.

J Leukoc Biol. 2010 Aug;88(2):233-40. doi: 10.1189/jlb.0110037. Epub 2010 May 18.


ISG12 is a critical modulator of innate immune responses in murine models of sepsis.

Uhrin P, Perkmann T, Binder B, Schabbauer G.

Immunobiology. 2013 Sep;218(9):1207-16. doi: 10.1016/j.imbio.2013.04.009. Epub 2013 Apr 19.


OX40 ligand regulates inflammation and mortality in the innate immune response to sepsis.

Karulf M, Kelly A, Weinberg AD, Gold JA.

J Immunol. 2010 Oct 15;185(8):4856-62. doi: 10.4049/jimmunol.1000404. Epub 2010 Sep 15.

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