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PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma.

Puustinen P, Junttila MR, Vanhatupa S, Sablina AA, Hector ME, Teittinen K, Raheem O, Ketola K, Lin S, Kast J, Haapasalo H, Hahn WC, Westermarck J.

Cancer Res. 2009 Apr 1;69(7):2870-7. doi: 10.1158/0008-5472.CAN-08-2760. Epub 2009 Mar 17.


PME-1 modulates protein phosphatase 2A activity to promote the malignant phenotype of endometrial cancer cells.

Wandzioch E, Pusey M, Werda A, Bail S, Bhaskar A, Nestor M, Yang JJ, Rice LM.

Cancer Res. 2014 Aug 15;74(16):4295-305. doi: 10.1158/0008-5472.CAN-13-3130. Epub 2014 Jun 13.


Protein phosphatase 2A-negative regulation of the protective signaling pathway of Ca2+/CaM-dependent ERK activation in cerebral ischemia.

Zhao J, Wu HW, Chen YJ, Tian HP, Li LX, Han X, Guo J.

J Neurosci Res. 2008 Sep;86(12):2733-45. doi: 10.1002/jnr.21712.


Activation of p38 mitogen-activated protein kinase is required for death receptor-independent caspase-8 activation and cell death in response to sphingosine.

Yoon CH, Kim MJ, Park MT, Byun JY, Choi YH, Yoo HS, Lee YM, Hyun JW, Lee SJ.

Mol Cancer Res. 2009 Mar;7(3):361-70. doi: 10.1158/1541-7786.MCR-08-0069. Epub 2009 Mar 10.


RACK1 targets the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway to link integrin engagement with focal adhesion disassembly and cell motility.

Vomastek T, Iwanicki MP, Schaeffer HJ, Tarcsafalvi A, Parsons JT, Weber MJ.

Mol Cell Biol. 2007 Dec;27(23):8296-305. Epub 2007 Oct 1.


Resistance to mitogen-activated protein kinase kinase (MEK) inhibitors correlates with up-regulation of the MEK/extracellular signal-regulated kinase pathway in hepatocellular carcinoma cells.

Yip-Schneider MT, Klein PJ, Wentz SC, Zeni A, Menze A, Schmidt CM.

J Pharmacol Exp Ther. 2009 Jun;329(3):1063-70. doi: 10.1124/jpet.108.147306. Epub 2009 Mar 3.


Insulin-like growth factor 1 inhibits extracellular signal-regulated kinase to promote neuronal survival via the phosphatidylinositol 3-kinase/protein kinase A/c-Raf pathway.

Subramaniam S, Shahani N, Strelau J, Laliberté C, Brandt R, Kaplan D, Unsicker K.

J Neurosci. 2005 Mar 16;25(11):2838-52.


EFA6A enhances glioma cell invasion through ADP ribosylation factor 6/extracellular signal-regulated kinase signaling.

Li M, Ng SS, Wang J, Lai L, Leung SY, Franco M, Peng Y, He ML, Kung HF, Lin MC.

Cancer Res. 2006 Feb 1;66(3):1583-90.


Tautomycetin inhibits growth of colorectal cancer cells through p21cip/WAF1 induction via the extracellular signal-regulated kinase pathway.

Lee JH, Lee JS, Kim SE, Moon BS, Kim YC, Lee SK, Lee SK, Choi KY.

Mol Cancer Ther. 2006 Dec;5(12):3222-31.


Structural mechanism of demethylation and inactivation of protein phosphatase 2A.

Xing Y, Li Z, Chen Y, Stock JB, Jeffrey PD, Shi Y.

Cell. 2008 Apr 4;133(1):154-63. doi: 10.1016/j.cell.2008.02.041.


The protein kinase C-eta isoform induces proliferation in glioblastoma cell lines through an ERK/Elk-1 pathway.

Uht RM, Amos S, Martin PM, Riggan AE, Hussaini IM.

Oncogene. 2007 May 3;26(20):2885-93. Epub 2006 Dec 4.


Rapid and transient activation of the ERK MAPK signalling pathway by macrophage migration inhibitory factor (MIF) and dependence on JAB1/CSN5 and Src kinase activity.

Lue H, Kapurniotu A, Fingerle-Rowson G, Roger T, Leng L, Thiele M, Calandra T, Bucala R, Bernhagen J.

Cell Signal. 2006 May;18(5):688-703. Epub 2005 Aug 24.


LRRC4 inhibits human glioblastoma cells proliferation, invasion, and proMMP-2 activation by reducing SDF-1 alpha/CXCR4-mediated ERK1/2 and Akt signaling pathways.

Wu M, Chen Q, Li D, Li X, Li X, Huang C, Tang Y, Zhou Y, Wang D, Tang K, Cao L, Shen S, Li G.

J Cell Biochem. 2008 Jan 1;103(1):245-55.


Spatial control of protein phosphatase 2A (de)methylation.

Longin S, Zwaenepoel K, Martens E, Louis JV, Rondelez E, Goris J, Janssens V.

Exp Cell Res. 2008 Jan 1;314(1):68-81. Epub 2007 Aug 7.


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