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Items: 1 to 20 of 184

1.

Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo.

Smith JJ, Kenney RD, Gagne DJ, Frushour BP, Ladd W, Galonek HL, Israelian K, Song J, Razvadauskaite G, Lynch AV, Carney DP, Johnson RJ, Lavu S, Iffland A, Elliott PJ, Lambert PD, Elliston KO, Jirousek MR, Milne JC, Boss O.

BMC Syst Biol. 2009 Mar 10;3:31. doi: 10.1186/1752-0509-3-31.

2.

SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1.

Pacholec M, Bleasdale JE, Chrunyk B, Cunningham D, Flynn D, Garofalo RS, Griffith D, Griffor M, Loulakis P, Pabst B, Qiu X, Stockman B, Thanabal V, Varghese A, Ward J, Withka J, Ahn K.

J Biol Chem. 2010 Mar 12;285(11):8340-51. doi: 10.1074/jbc.M109.088682. Epub 2010 Jan 8.

3.

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.

Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, Bemis JE, Xie R, Disch JS, Ng PY, Nunes JJ, Lynch AV, Yang H, Galonek H, Israelian K, Choy W, Iffland A, Lavu S, Medvedik O, Sinclair DA, Olefsky JM, Jirousek MR, Elliott PJ, Westphal CH.

Nature. 2007 Nov 29;450(7170):712-6.

4.

Sirtuins: novel targets for metabolic disease in drug development.

Jiang WJ.

Biochem Biophys Res Commun. 2008 Aug 29;373(3):341-4. doi: 10.1016/j.bbrc.2008.06.048. Epub 2008 Jun 23. Review.

PMID:
18577374
5.

SIRT1-independent mechanisms of the putative sirtuin enzyme activators SRT1720 and SRT2183.

Huber JL, McBurney MW, Distefano PS, McDonagh T.

Future Med Chem. 2010 Dec;2(12):1751-9. doi: 10.4155/fmc.10.257.

PMID:
21428798
6.

Metabolic benefits from Sirt1 and Sirt1 activators.

Chaudhary N, Pfluger PT.

Curr Opin Clin Nutr Metab Care. 2009 Jul;12(4):431-7. doi: 10.1097/MCO.0b013e32832cdaae. Review.

PMID:
19474719
7.

Biochemical effects of SIRT1 activators.

Baur JA.

Biochim Biophys Acta. 2010 Aug;1804(8):1626-34. doi: 10.1016/j.bbapap.2009.10.025. Epub 2009 Nov 6. Review.

8.

Discovery of oxazolo[4,5-b]pyridines and related heterocyclic analogs as novel SIRT1 activators.

Bemis JE, Vu CB, Xie R, Nunes JJ, Ng PY, Disch JS, Milne JC, Carney DP, Lynch AV, Jin L, Smith JJ, Lavu S, Iffland A, Jirousek MR, Perni RB.

Bioorg Med Chem Lett. 2009 Apr 15;19(8):2350-3. doi: 10.1016/j.bmcl.2008.11.106. Epub 2008 Dec 6.

PMID:
19303289
9.

The expression of SIRT1 in nonalcoholic fatty liver disease induced by high-fat diet in rats.

Deng XQ, Chen LL, Li NX.

Liver Int. 2007 Jun;27(5):708-15.

PMID:
17498258
10.

Calorie restriction in overweight males ameliorates obesity-related metabolic alterations and cellular adaptations through anti-aging effects, possibly including AMPK and SIRT1 activation.

Kitada M, Kume S, Takeda-Watanabe A, Tsuda S, Kanasaki K, Koya D.

Biochim Biophys Acta. 2013 Oct;1830(10):4820-7. doi: 10.1016/j.bbagen.2013.06.014. Epub 2013 Jun 23.

PMID:
23800577
11.

Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation.

Feige JN, Lagouge M, Canto C, Strehle A, Houten SM, Milne JC, Lambert PD, Mataki C, Elliott PJ, Auwerx J.

Cell Metab. 2008 Nov;8(5):347-58. doi: 10.1016/j.cmet.2008.08.017. Erratum in: Cell Metab. 2009 Feb;9(2):210.

12.

SIRT1 activator (SRT1720) improves the follicle reserve and prolongs the ovarian lifespan of diet-induced obesity in female mice via activating SIRT1 and suppressing mTOR signaling.

Zhou XL, Xu JJ, Ni YH, Chen XC, Zhang HX, Zhang XM, Liu WJ, Luo LL, Fu YC.

J Ovarian Res. 2014 Oct 21;7:97. doi: 10.1186/s13048-014-0097-z.

13.

Sirtuins regulate key aspects of lipid metabolism.

Lomb DJ, Laurent G, Haigis MC.

Biochim Biophys Acta. 2010 Aug;1804(8):1652-7. doi: 10.1016/j.bbapap.2009.11.021. Epub 2009 Dec 2. Review.

PMID:
19962456
14.

Sirtuin activators: designing molecules to extend life span.

Camins A, Sureda FX, Junyent F, Verdaguer E, Folch J, Pelegri C, Vilaplana J, Beas-Zarate C, Pallàs M.

Biochim Biophys Acta. 2010 Oct-Dec;1799(10-12):740-9. doi: 10.1016/j.bbagrm.2010.06.005. Epub 2010 Jun 23. Review.

PMID:
20601277
15.

Calorie restriction--the SIR2 connection.

Guarente L, Picard F.

Cell. 2005 Feb 25;120(4):473-82. Review.

16.

[Effects of calorie restriction on SIRT1 expression in liver of nonalcoholic fatty liver disease: experiment with rats].

Chen LL, Deng XQ, Li NX.

Zhonghua Yi Xue Za Zhi. 2007 May 29;87(20):1434-7. Chinese.

PMID:
17785073
17.

Protective role of SIRT1 in diabetic vascular dysfunction.

Orimo M, Minamino T, Miyauchi H, Tateno K, Okada S, Moriya J, Komuro I.

Arterioscler Thromb Vasc Biol. 2009 Jun;29(6):889-94. doi: 10.1161/ATVBAHA.109.185694. Epub 2009 Mar 12.

18.

Silencing metabolic disorders by novel SIRT1 activators.

Sakamoto K.

Cell Metab. 2008 Jan;7(1):3-4. doi: 10.1016/j.cmet.2007.12.005.

19.

The controversial links among calorie restriction, SIRT1, and resveratrol.

Hu Y, Liu J, Wang J, Liu Q.

Free Radic Biol Med. 2011 Jul 15;51(2):250-6. doi: 10.1016/j.freeradbiomed.2011.04.034. Epub 2011 Apr 22. Review.

PMID:
21569839
20.

Sirtuin activators.

Alcaín FJ, Villalba JM.

Expert Opin Ther Pat. 2009 Apr;19(4):403-14. doi: 10.1517/13543770902762893. Review.

PMID:
19441923
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