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Items: 1 to 20 of 120

1.

The multimeric structure of polycystin-2 (TRPP2): structural-functional correlates of homo- and hetero-multimers with TRPC1.

Zhang P, Luo Y, Chasan B, González-Perrett S, Montalbetti N, Timpanaro GA, Cantero Mdel R, Ramos AJ, Goldmann WH, Zhou J, Cantiello HF.

Hum Mol Genet. 2009 Apr 1;18(7):1238-51. doi: 10.1093/hmg/ddp024. Epub 2009 Feb 3.

2.

A single amino acid residue constitutes the third dimerization domain essential for the assembly and function of the tetrameric polycystin-2 (TRPP2) channel.

Feng S, Rodat-Despoix L, Delmas P, Ong AC.

J Biol Chem. 2011 May 27;286(21):18994-9000. doi: 10.1074/jbc.M110.192286. Epub 2011 Apr 7.

3.

A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes.

Giamarchi A, Feng S, Rodat-Despoix L, Xu Y, Bubenshchikova E, Newby LJ, Hao J, Gaudioso C, Crest M, Lupas AN, Honoré E, Williamson MP, Obara T, Ong AC, Delmas P.

EMBO J. 2010 Apr 7;29(7):1176-91. doi: 10.1038/emboj.2010.18. Epub 2010 Feb 18.

4.

The transient receptor potential channels TRPP2 and TRPC1 form a heterotetramer with a 2:2 stoichiometry and an alternating subunit arrangement.

Kobori T, Smith GD, Sandford R, Edwardson JM.

J Biol Chem. 2009 Dec 18;284(51):35507-13. doi: 10.1074/jbc.M109.060228.

5.

Extracellular Loops Are Essential for the Assembly and Function of Polycystin Receptor-Ion Channel Complexes.

Salehi-Najafabadi Z, Li B, Valentino V, Ng C, Martin H, Yu Y, Wang Z, Kashyap P, Yu Y.

J Biol Chem. 2017 Mar 10;292(10):4210-4221. doi: 10.1074/jbc.M116.767897. Epub 2017 Feb 2.

PMID:
28154010
6.

TRPV4, TRPC1, and TRPP2 assemble to form a flow-sensitive heteromeric channel.

Du J, Ma X, Shen B, Huang Y, Birnbaumer L, Yao X.

FASEB J. 2014 Nov;28(11):4677-85. doi: 10.1096/fj.14-251652. Epub 2014 Aug 11.

7.

Mediation of angiotensin II-induced Ca2+ signaling by polycystin 2 in glomerular mesangial cells.

Du J, Ding M, Sours-Brothers S, Graham S, Ma R.

Am J Physiol Renal Physiol. 2008 Apr;294(4):F909-18. doi: 10.1152/ajprenal.00606.2007. Epub 2008 Feb 6. Erratum in: Am J Physiol Renal Physiol. 2008 Apr;294(4):F917.

8.

Formation of a new receptor-operated channel by heteromeric assembly of TRPP2 and TRPC1 subunits.

Bai CX, Giamarchi A, Rodat-Despoix L, Padilla F, Downs T, Tsiokas L, Delmas P.

EMBO Rep. 2008 May;9(5):472-9. doi: 10.1038/embor.2008.29. Epub 2008 Mar 7.

9.

Identification and functional characterization of an N-terminal oligomerization domain for polycystin-2.

Feng S, Okenka GM, Bai CX, Streets AJ, Newby LJ, DeChant BT, Tsiokas L, Obara T, Ong AC.

J Biol Chem. 2008 Oct 17;283(42):28471-9. doi: 10.1074/jbc.M803834200. Epub 2008 Aug 13.

10.

External Ca2+ regulates polycystin-2 (TRPP2) cation currents in LLC-PK1 renal epithelial cells.

Dai XQ, Perez PL, Soria G, Scarinci N, Smoler M, Morsucci DC, Suzuki K, Cantero MD, Cantiello HF.

Exp Cell Res. 2017 Jan 1;350(1):50-61. doi: 10.1016/j.yexcr.2016.11.004. Epub 2016 Nov 9.

PMID:
27836810
11.

Effect of lithium on the electrical properties of polycystin-2 (TRPP2).

Cantero Mdel R, Cantiello HF.

Eur Biophys J. 2011 Sep;40(9):1029-42. doi: 10.1007/s00249-011-0715-2. Epub 2011 Jun 16.

PMID:
21678023
12.

Calcium-induced conformational changes in C-terminal tail of polycystin-2 are necessary for channel gating.

Ćelić AS, Petri ET, Benbow J, Hodsdon ME, Ehrlich BE, Boggon TJ.

J Biol Chem. 2012 May 18;287(21):17232-40. doi: 10.1074/jbc.M112.354613. Epub 2012 Apr 3.

13.

Oligomerization of the polycystin-2 C-terminal tail and effects on its Ca2+-binding properties.

Yang Y, Keeler C, Kuo IY, Lolis EJ, Ehrlich BE, Hodsdon ME.

J Biol Chem. 2015 Apr 17;290(16):10544-54. doi: 10.1074/jbc.M115.641803. Epub 2015 Feb 25.

14.

Structural studies of the C-terminal tail of polycystin-2 (PC2) reveal insights into the mechanisms used for the functional regulation of PC2.

Yang Y, Ehrlich BE.

J Physiol. 2016 Aug 1;594(15):4141-9. doi: 10.1113/JP270933. Epub 2016 Apr 27. Review.

15.

Structure of the EF-hand domain of polycystin-2 suggests a mechanism for Ca2+-dependent regulation of polycystin-2 channel activity.

Petri ET, Celic A, Kennedy SD, Ehrlich BE, Boggon TJ, Hodsdon ME.

Proc Natl Acad Sci U S A. 2010 May 18;107(20):9176-81. doi: 10.1073/pnas.0912295107. Epub 2010 May 3.

16.

A pathogenic C terminus-truncated polycystin-2 mutant enhances receptor-activated Ca2+ entry via association with TRPC3 and TRPC7.

Miyagi K, Kiyonaka S, Yamada K, Miki T, Mori E, Kato K, Numata T, Sawaguchi Y, Numaga T, Kimura T, Kanai Y, Kawano M, Wakamori M, Nomura H, Koni I, Yamagishi M, Mori Y.

J Biol Chem. 2009 Dec 4;284(49):34400-12. doi: 10.1074/jbc.M109.015149. Epub 2009 Oct 7.

17.

Organic cation permeation through the channel formed by polycystin-2.

Anyatonwu GI, Ehrlich BE.

J Biol Chem. 2005 Aug 19;280(33):29488-93. Epub 2005 Jun 16.

18.

Polycystin-2 (TRPP2) Regulation by Ca(2+) Is Effected and Diversified by Actin-Binding Proteins.

Cantero Mdel R, Cantiello HF.

Biophys J. 2015 May 5;108(9):2191-200. doi: 10.1016/j.bpj.2015.03.050.

19.

Voltage dependence and pH regulation of human polycystin-2-mediated cation channel activity.

Gonzalez-Perrett S, Batelli M, Kim K, Essafi M, Timpanaro G, Moltabetti N, Reisin IL, Arnaout MA, Cantiello HF.

J Biol Chem. 2002 Jul 12;277(28):24959-66. Epub 2002 May 3.

20.

Polycystin-2 cation channel function in the human syncytiotrophoblast is regulated by microtubular structures.

Montalbetti N, Li Q, Wu Y, Chen XZ, Cantiello HF.

J Physiol. 2007 Mar 15;579(Pt 3):717-28. Epub 2007 Jan 4.

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