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Items: 1 to 20 of 72

1.

CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling.

Schulthess FT, Paroni F, Sauter NS, Shu L, Ribaux P, Haataja L, Strieter RM, Oberholzer J, King CC, Maedler K.

Cell Metab. 2009 Feb;9(2):125-39. doi: 10.1016/j.cmet.2009.01.003.

2.

CXCL10- a path to β-cell death.

Paroni F, Domsgen E, Maedler K.

Islets. 2009 Nov-Dec;1(3):256-9. doi: 10.4161/isl.1.3.9110.

PMID:
21099280
3.

CXCL10 contributes to p38-mediated apoptosis in primary T lymphocytes in vitro.

Sidahmed AM, León AJ, Bosinger SE, Banner D, Danesh A, Cameron MJ, Kelvin DJ.

Cytokine. 2012 Aug;59(2):433-41. doi: 10.1016/j.cyto.2012.05.002. Epub 2012 May 30.

4.

Puerarin protects pancreatic β-cell survival via PI3K/Akt signaling pathway.

Li Z, Shangguan Z, Liu Y, Wang J, Li X, Yang S, Liu S.

J Mol Endocrinol. 2014 Aug;53(1):71-9. doi: 10.1530/JME-13-0302. Epub 2014 May 14.

PMID:
24827001
5.

The lysine deacetylase inhibitor Givinostat inhibits β-cell IL-1β induced IL-1β transcription and processing.

Dahllöf MS, Christensen DP, Lundh M, Dinarello CA, Mascagni P, Grunnet LG, Mandrup-Poulsen T.

Islets. 2012 Nov-Dec;4(6):417-22. doi: 10.4161/isl.23541.

6.

Enterovirus infection, CXC chemokine ligand 10 (CXCL10), and CXCR3 circuit: a mechanism of accelerated beta-cell failure in fulminant type 1 diabetes.

Tanaka S, Nishida Y, Aida K, Maruyama T, Shimada A, Suzuki M, Shimura H, Takizawa S, Takahashi M, Akiyama D, Arai-Yamashita S, Furuya F, Kawaguchi A, Kaneshige M, Katoh R, Endo T, Kobayashi T.

Diabetes. 2009 Oct;58(10):2285-91. doi: 10.2337/db09-0091. Epub 2009 Jul 29.

7.

Phenylmethimazole suppresses dsRNA-induced cytotoxicity and inflammatory cytokines in murine pancreatic beta cells and blocks viral acceleration of type 1 diabetes in NOD mice.

McCall KD, Schmerr MJ, Thuma JR, James CB, Courreges MC, Benencia F, Malgor R, Schwartz FL.

Molecules. 2013 Mar 27;18(4):3841-58. doi: 10.3390/molecules18043841.

8.

Fetuin A promotes lipotoxicity in β cells through the TLR4 signaling pathway and the role of pioglitazone in anti-lipotoxicity.

Shen X, Yang L, Yan S, Zheng H, Liang L, Cai X, Liao M.

Mol Cell Endocrinol. 2015 Sep 5;412:1-11. doi: 10.1016/j.mce.2015.05.014. Epub 2015 May 15.

PMID:
25986658
9.

Proapoptotic effects of the chemokine, CXCL 10 are mediated by the noncognate receptor TLR4 in hepatocytes.

Sahin H, Borkham-Kamphorst E, do O NT, Berres ML, Kaldenbach M, Schmitz P, Weiskirchen R, Liedtke C, Streetz KL, Maedler K, Trautwein C, Wasmuth HE.

Hepatology. 2013 Feb;57(2):797-805. doi: 10.1002/hep.26069. Epub 2013 Jan 8.

PMID:
22996399
10.

TYK2, a Candidate Gene for Type 1 Diabetes, Modulates Apoptosis and the Innate Immune Response in Human Pancreatic β-Cells.

Marroqui L, Dos Santos RS, Fløyel T, Grieco FA, Santin I, Op de Beeck A, Marselli L, Marchetti P, Pociot F, Eizirik DL.

Diabetes. 2015 Nov;64(11):3808-17. doi: 10.2337/db15-0362. Epub 2015 Aug 3.

11.

Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic beta-cells and human islets: involvement of 3',5'-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-Kinase/Akt signaling.

Granata R, Settanni F, Biancone L, Trovato L, Nano R, Bertuzzi F, Destefanis S, Annunziata M, Martinetti M, Catapano F, Ghè C, Isgaard J, Papotti M, Ghigo E, Muccioli G.

Endocrinology. 2007 Feb;148(2):512-29. Epub 2006 Oct 26.

PMID:
17068144
12.

Increased expression of toll-like receptor 4 and inflammatory cytokines, interleukin-6 in particular, in islets from a mouse model of obesity and type 2 diabetes.

Ladefoged M, Buschard K, Hansen AM.

APMIS. 2013 Jun;121(6):531-8. doi: 10.1111/apm.12018. Epub 2012 Nov 8.

PMID:
23134512
13.

CXCR3, CXCL10 and type 1 diabetes.

Antonelli A, Ferrari SM, Corrado A, Ferrannini E, Fallahi P.

Cytokine Growth Factor Rev. 2014 Feb;25(1):57-65. doi: 10.1016/j.cytogfr.2014.01.006. Epub 2014 Jan 28. Review.

PMID:
24529741
14.

Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways.

Wente W, Efanov AM, Brenner M, Kharitonenkov A, Köster A, Sandusky GE, Sewing S, Treinies I, Zitzer H, Gromada J.

Diabetes. 2006 Sep;55(9):2470-8.

15.

CXCL10 activities, biological structure, and source along with its significant role played in pathophysiology of type I diabetes mellitus.

Ahmadi Z, Arababadi MK, Hassanshahi G.

Inflammation. 2013 Apr;36(2):364-71. doi: 10.1007/s10753-012-9555-1. Review.

PMID:
23065240
16.

Toll-like receptor 4 (TLR4) expression in human and murine pancreatic beta-cells affects cell viability and insulin homeostasis.

Garay-Malpartida HM, Mourão RF, Mantovani M, Santos IA, Sogayar MC, Goldberg AC.

BMC Immunol. 2011 Feb 28;12:18. doi: 10.1186/1471-2172-12-18.

17.

CXCL10 expression induced by Mxi1 inactivation induces mesangial cell apoptosis in mouse Habu nephritis.

Wu L, Chen X, Mei Y, Hong Q, Feng Z, Lv Y, Wen J, Liu X, Cai G, Chen X.

Cell Signal. 2015 May;27(5):943-50. doi: 10.1016/j.cellsig.2015.01.019. Epub 2015 Feb 12.

PMID:
25683914
18.

Th1-Like ICOS+ Foxp3+ Treg Cells Preferentially Express CXCR3 and Home to β-Islets during Pre-Diabetes in BDC2.5 NOD Mice.

Kornete M, Mason ES, Girouard J, Lafferty EI, Qureshi S, Piccirillo CA.

PLoS One. 2015 May 6;10(5):e0126311. doi: 10.1371/journal.pone.0126311. eCollection 2015.

19.

Exercise increases pancreatic β-cell viability in a model of type 1 diabetes through IL-6 signaling.

Paula FM, Leite NC, Vanzela EC, Kurauti MA, Freitas-Dias R, Carneiro EM, Boschero AC, Zoppi CC.

FASEB J. 2015 May;29(5):1805-16. doi: 10.1096/fj.14-264820. Epub 2015 Jan 21.

PMID:
25609426
20.

The orphan nuclear receptor small heterodimer partner negatively regulates pancreatic beta cell survival and hyperglycemia in multiple low-dose streptozotocin-induced type 1 diabetic mice.

Noh JR, Hwang JH, Kim YH, Kim KS, Gang GT, Kim SW, Kim DK, Shong M, Lee IK, Choi HS, Lee CH.

Int J Biochem Cell Biol. 2013 Aug;45(8):1538-45. doi: 10.1016/j.biocel.2013.05.004. Epub 2013 May 13.

PMID:
23680671

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