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Valproic acid activates the PI3K/Akt/mTOR pathway in muscle and ameliorates pathology in a mouse model of Duchenne muscular dystrophy.

Gurpur PB, Liu J, Burkin DJ, Kaufman SJ.

Am J Pathol. 2009 Mar;174(3):999-1008. doi: 10.2353/ajpath.2009.080537. Epub 2009 Jan 29.


Activation of AKT signaling promotes cell growth and survival in α7β1 integrin-mediated alleviation of muscular dystrophy.

Boppart MD, Burkin DJ, Kaufman SJ.

Biochim Biophys Acta. 2011 Apr;1812(4):439-46. doi: 10.1016/j.bbadis.2011.01.002. Epub 2011 Jan 7.


MicroRNA-486-dependent modulation of DOCK3/PTEN/AKT signaling pathways improves muscular dystrophy-associated symptoms.

Alexander MS, Casar JC, Motohashi N, Vieira NM, Eisenberg I, Marshall JL, Gasperini MJ, Lek A, Myers JA, Estrella EA, Kang PB, Shapiro F, Rahimov F, Kawahara G, Widrick JJ, Kunkel LM.

J Clin Invest. 2014 Jun;124(6):2651-67. doi: 10.1172/JCI73579. Epub 2014 May 1.


Transforming growth factor type-β inhibits Mas receptor expression in fibroblasts but not in myoblasts or differentiated myotubes; Relevance to fibrosis associated to muscular dystrophies.

Cofre C, Acuña MJ, Contreras O, Morales MG, Riquelme C, Cabello-Verrugio C, Brandan E.

Biofactors. 2015 Mar-Apr;41(2):111-20. doi: 10.1002/biof.1208. Epub 2015 Mar 23. Erratum in: Biofactors. 2015 May 6;41(3):209.


Rapamycin ameliorates dystrophic phenotype in mdx mouse skeletal muscle.

Eghtesad S, Jhunjhunwala S, Little SR, Clemens PR.

Mol Med. 2011 Sep-Oct;17(9-10):917-24. doi: 10.2119/molmed.2010.00256. Epub 2011 May 20.


Hypertrophic response of Duchenne and limb-girdle muscular dystrophies is associated with activation of Akt pathway.

Peter AK, Crosbie RH.

Exp Cell Res. 2006 Aug 1;312(13):2580-91. Epub 2006 May 22.


PTEN contributes to profound PI3K/Akt signaling pathway deregulation in dystrophin-deficient dog muscle.

Feron M, Guevel L, Rouger K, Dubreil L, Arnaud MC, Ledevin M, Megeney LA, Cherel Y, Sakanyan V.

Am J Pathol. 2009 Apr;174(4):1459-70. doi: 10.2353/ajpath.2009.080460. Epub 2009 Mar 5.


Levels of α7 integrin and laminin-α2 are increased following prednisone treatment in the mdx mouse and GRMD dog models of Duchenne muscular dystrophy.

Wuebbles RD, Sarathy A, Kornegay JN, Burkin DJ.

Dis Model Mech. 2013 Sep;6(5):1175-84. doi: 10.1242/dmm.012211. Epub 2013 Jul 11.


Enhanced expression of the alpha 7 beta 1 integrin reduces muscular dystrophy and restores viability in dystrophic mice.

Burkin DJ, Wallace GQ, Nicol KJ, Kaufman DJ, Kaufman SJ.

J Cell Biol. 2001 Mar 19;152(6):1207-18.


A growth stimulus is needed for IGF-1 to induce skeletal muscle hypertrophy in vivo.

Shavlakadze T, Chai J, Maley K, Cozens G, Grounds G, Winn N, Rosenthal N, Grounds MD.

J Cell Sci. 2010 Mar 15;123(Pt 6):960-71. doi: 10.1242/jcs.061119. Epub 2010 Feb 23. Erratum in: J Cell Sci. 2013 Oct 1;126(Pt 19):4536.


Valproic acid enhances Oct4 promoter activity through PI3K/Akt/mTOR pathway activated nuclear receptors.

Teng HF, Li PN, Hou DR, Liu SW, Lin CT, Loo MR, Kao CH, Lin KH, Chen SL.

Mol Cell Endocrinol. 2014 Mar 5;383(1-2):147-58. doi: 10.1016/j.mce.2013.12.008. Epub 2013 Dec 19.


Overexpression of Galgt2 in skeletal muscle prevents injury resulting from eccentric contractions in both mdx and wild-type mice.

Martin PT, Xu R, Rodino-Klapac LR, Oglesbay E, Camboni M, Montgomery CL, Shontz K, Chicoine LG, Clark KR, Sahenk Z, Mendell JR, Janssen PM.

Am J Physiol Cell Physiol. 2009 Mar;296(3):C476-88. doi: 10.1152/ajpcell.00456.2008. Epub 2008 Dec 24.


The fibrotic role of phosphatidylinositol-3-kinase/Akt pathway in injured skeletal muscle after acute contusion.

Li HY, Zhang QG, Chen JW, Chen SQ, Chen SY.

Int J Sports Med. 2013 Sep;34(9):789-94. doi: 10.1055/s-0032-1333284. Epub 2013 Feb 26.


Severe muscular dystrophy in mice that lack dystrophin and alpha7 integrin.

Rooney JE, Welser JV, Dechert MA, Flintoff-Dye NL, Kaufman SJ, Burkin DJ.

J Cell Sci. 2006 Jun 1;119(Pt 11):2185-95. Epub 2006 May 9.


Absence of alpha 7 integrin in dystrophin-deficient mice causes a myopathy similar to Duchenne muscular dystrophy.

Guo C, Willem M, Werner A, Raivich G, Emerson M, Neyses L, Mayer U.

Hum Mol Genet. 2006 Mar 15;15(6):989-98. Epub 2006 Feb 13.


A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells.

Sekulić A, Hudson CC, Homme JL, Yin P, Otterness DM, Karnitz LM, Abraham RT.

Cancer Res. 2000 Jul 1;60(13):3504-13.


Bowman-Birk inhibitor attenuates dystrophic pathology in mdx mice.

Morris CA, Selsby JT, Morris LD, Pendrak K, Sweeney HL.

J Appl Physiol (1985). 2010 Nov;109(5):1492-9. doi: 10.1152/japplphysiol.01283.2009. Epub 2010 Sep 16.


Inhibition of prostaglandin D synthase suppresses muscular necrosis.

Mohri I, Aritake K, Taniguchi H, Sato Y, Kamauchi S, Nagata N, Maruyama T, Taniike M, Urade Y.

Am J Pathol. 2009 May;174(5):1735-44. doi: 10.2353/ajpath.2009.080709. Epub 2009 Apr 9.

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