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pH-regulated mechanisms account for pigment-type differences in epidermal barrier function.

Gunathilake R, Schurer NY, Shoo BA, Celli A, Hachem JP, Crumrine D, Sirimanna G, Feingold KR, Mauro TM, Elias PM.

J Invest Dermatol. 2009 Jul;129(7):1719-29. doi: 10.1038/jid.2008.442. Epub 2009 Jan 29.


Basis for enhanced barrier function of pigmented skin.

Man MQ, Lin TK, Santiago JL, Celli A, Zhong L, Huang ZM, Roelandt T, Hupe M, Sundberg JP, Silva KA, Crumrine D, Martin-Ezquerra G, Trullas C, Sun R, Wakefield JS, Wei ML, Feingold KR, Mauro TM, Elias PM.

J Invest Dermatol. 2014 Sep;134(9):2399-2407. doi: 10.1038/jid.2014.187. Epub 2014 Apr 14.


Facial skin pigmentation is not related to stratum corneum cohesion, basal transepidermal water loss, barrier integrity and barrier repair.

Voegeli R, Rawlings AV, Summers B.

Int J Cosmet Sci. 2015 Apr;37(2):241-52. doi: 10.1111/ics.12189. Epub 2015 Jan 21.


Sustained serine proteases activity by prolonged increase in pH leads to degradation of lipid processing enzymes and profound alterations of barrier function and stratum corneum integrity.

Hachem JP, Man MQ, Crumrine D, Uchida Y, Brown BE, Rogiers V, Roseeuw D, Feingold KR, Elias PM.

J Invest Dermatol. 2005 Sep;125(3):510-20.


pH directly regulates epidermal permeability barrier homeostasis, and stratum corneum integrity/cohesion.

Hachem JP, Crumrine D, Fluhr J, Brown BE, Feingold KR, Elias PM.

J Invest Dermatol. 2003 Aug;121(2):345-53.


Functional consequences of a neutral pH in neonatal rat stratum corneum.

Fluhr JW, Mao-Qiang M, Brown BE, Hachem JP, Moskowitz DG, Demerjian M, Haftek M, Serre G, Crumrine D, Mauro TM, Elias PM, Feingold KR.

J Invest Dermatol. 2004 Jul;123(1):140-51.


Topical peroxisome proliferator activated receptor activators accelerate postnatal stratum corneum acidification.

Fluhr JW, Man MQ, Hachem JP, Crumrine D, Mauro TM, Elias PM, Feingold KR.

J Invest Dermatol. 2009 Feb;129(2):365-74. doi: 10.1038/jid.2008.218. Epub 2008 Aug 14.


Skin type, but neither race nor gender, influence epidermal permeability barrier function.

Reed JT, Ghadially R, Elias PM.

Arch Dermatol. 1995 Oct;131(10):1134-8.


Stratum corneum acidification in neonatal skin: secretory phospholipase A2 and the sodium/hydrogen antiporter-1 acidify neonatal rat stratum corneum.

Fluhr JW, Behne MJ, Brown BE, Moskowitz DG, Selden C, Mao-Qiang M, Mauro TM, Elias PM, Feingold KR.

J Invest Dermatol. 2004 Feb;122(2):320-9.


Increased stratum corneum serine protease activity in acute eczematous atopic skin.

Voegeli R, Rawlings AV, Breternitz M, Doppler S, Schreier T, Fluhr JW.

Br J Dermatol. 2009 Jul;161(1):70-7. doi: 10.1111/j.1365-2133.2009.09142.x. Epub 2009 Mar 30. Erratum in: Br J Dermatol. 2009 Aug;161(2):492.


Increased basal transepidermal water loss leads to elevation of some but not all stratum corneum serine proteases.

Voegeli R, Rawlings AV, Doppler S, Schreier T.

Int J Cosmet Sci. 2008 Dec;30(6):435-42. doi: 10.1111/j.1468-2494.2008.00472.x.


Acute acidification of stratum corneum membrane domains using polyhydroxyl acids improves lipid processing and inhibits degradation of corneodesmosomes.

Hachem JP, Roelandt T, Schürer N, Pu X, Fluhr J, Giddelo C, Man MQ, Crumrine D, Roseeuw D, Feingold KR, Mauro T, Elias PM.

J Invest Dermatol. 2010 Feb;130(2):500-10. doi: 10.1038/jid.2009.249. Epub 2009 Sep 10.


Generation of free fatty acids from phospholipids regulates stratum corneum acidification and integrity.

Fluhr JW, Kao J, Jain M, Ahn SK, Feingold KR, Elias PM.

J Invest Dermatol. 2001 Jul;117(1):44-51.


Short-term glucocorticoid treatment compromises both permeability barrier homeostasis and stratum corneum integrity: inhibition of epidermal lipid synthesis accounts for functional abnormalities.

Kao JS, Fluhr JW, Man MQ, Fowler AJ, Hachem JP, Crumrine D, Ahn SK, Brown BE, Elias PM, Feingold KR.

J Invest Dermatol. 2003 Mar;120(3):456-64.


Neonatal development of the stratum corneum pH gradient: localization and mechanisms leading to emergence of optimal barrier function.

Behne MJ, Barry NP, Hanson KM, Aronchik I, Clegg RW, Gratton E, Feingold K, Holleran WM, Elias PM, Mauro TM.

J Invest Dermatol. 2003 Jun;120(6):998-1006.


Barrier requirements as the evolutionary "driver" of epidermal pigmentation in humans.

Elias PM, Menon G, Wetzel BK, Williams J.

Am J Hum Biol. 2010 Jul-Aug;22(4):526-37. doi: 10.1002/ajhb.21043.


Epidermal permeability barrier recovery is delayed in vitiligo-involved sites.

Liu J, Man WY, Lv CZ, Song SP, Shi YJ, Elias PM, Man MQ.

Skin Pharmacol Physiol. 2010;23(4):193-200. doi: 10.1159/000288166. Epub 2010 Feb 25.


Serine protease signaling of epidermal permeability barrier homeostasis.

Hachem JP, Houben E, Crumrine D, Man MQ, Schurer N, Roelandt T, Choi EH, Uchida Y, Brown BE, Feingold KR, Elias PM.

J Invest Dermatol. 2006 Sep;126(9):2074-86. Epub 2006 May 11.


The aged epidermal permeability barrier. Structural, functional, and lipid biochemical abnormalities in humans and a senescent murine model.

Ghadially R, Brown BE, Sequeira-Martin SM, Feingold KR, Elias PM.

J Clin Invest. 1995 May;95(5):2281-90.

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