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Items: 1 to 20 of 153

1.

Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome.

Imaeda AB, Watanabe A, Sohail MA, Mahmood S, Mohamadnejad M, Sutterwala FS, Flavell RA, Mehal WZ.

J Clin Invest. 2009 Feb;119(2):305-14. doi: 10.1172/JCI35958. Epub 2009 Jan 26.

2.

Role of the Nalp3 inflammasome in acetaminophen-induced sterile inflammation and liver injury.

Williams CD, Antoine DJ, Shaw PJ, Benson C, Farhood A, Williams DP, Kanneganti TD, Park BK, Jaeschke H.

Toxicol Appl Pharmacol. 2011 May 1;252(3):289-97. doi: 10.1016/j.taap.2011.03.001. Epub 2011 Mar 21.

3.

The NALP3 inflammasome is involved in neurotoxic prion peptide-induced microglial activation.

Shi F, Yang L, Kouadir M, Yang Y, Wang J, Zhou X, Yin X, Zhao D.

J Neuroinflammation. 2012 Jul 11;9:73. doi: 10.1186/1742-2094-9-73.

4.

DAMPs ramp up drug toxicity.

Maher JJ.

J Clin Invest. 2009 Feb;119(2):246-9.

5.

Activation of the IL-1beta-processing inflammasome is involved in contact hypersensitivity.

Watanabe H, Gaide O, Pétrilli V, Martinon F, Contassot E, Roques S, Kummer JA, Tschopp J, French LE.

J Invest Dermatol. 2007 Aug;127(8):1956-63. Epub 2007 Apr 12.

6.

Role of caspase-1 and interleukin-1beta in acetaminophen-induced hepatic inflammation and liver injury.

Williams CD, Farhood A, Jaeschke H.

Toxicol Appl Pharmacol. 2010 Sep 15;247(3):169-78. doi: 10.1016/j.taap.2010.07.004. Epub 2010 Jul 15.

7.

Lipopolysaccharide induces and activates the Nalp3 inflammasome in the liver.

Ganz M, Csak T, Nath B, Szabo G.

World J Gastroenterol. 2011 Nov 21;17(43):4772-8. doi: 10.3748/wjg.v17.i43.4772.

8.

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants.

Eisenbarth SC, Colegio OR, O'Connor W, Sutterwala FS, Flavell RA.

Nature. 2008 Jun 19;453(7198):1122-6. doi: 10.1038/nature06939. Epub 2008 May 21.

9.

Pure Hemozoin is inflammatory in vivo and activates the NALP3 inflammasome via release of uric acid.

Griffith JW, Sun T, McIntosh MT, Bucala R.

J Immunol. 2009 Oct 15;183(8):5208-20. doi: 10.4049/jimmunol.0713552. Epub 2009 Sep 25.

10.

Gene silencing of NALP3 protects against liver ischemia-reperfusion injury in mice.

Zhu P, Duan L, Chen J, Xiong A, Xu Q, Zhang H, Zheng F, Tan Z, Gong F, Fang M.

Hum Gene Ther. 2011 Jul;22(7):853-64. doi: 10.1089/hum.2010.145. Epub 2011 Mar 7.

PMID:
21128730
11.

Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells.

Csak T, Ganz M, Pespisa J, Kodys K, Dolganiuc A, Szabo G.

Hepatology. 2011 Jul;54(1):133-44. doi: 10.1002/hep.24341.

12.

Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis.

Gasse P, Riteau N, Charron S, Girre S, Fick L, Pétrilli V, Tschopp J, Lagente V, Quesniaux VF, Ryffel B, Couillin I.

Am J Respir Crit Care Med. 2009 May 15;179(10):903-13. doi: 10.1164/rccm.200808-1274OC. Epub 2009 Feb 12.

PMID:
19218193
13.

Purinergic receptor antagonist A438079 protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activation.

Xie Y, Williams CD, McGill MR, Lebofsky M, Ramachandran A, Jaeschke H.

Toxicol Sci. 2013 Jan;131(1):325-35. doi: 10.1093/toxsci/kfs283. Epub 2012 Sep 17.

14.

Heatstroke induces liver injury via IL-1β and HMGB1-induced pyroptosis.

Geng Y, Ma Q, Liu YN, Peng N, Yuan FF, Li XG, Li M, Wu YS, Li BL, Song WB, Zhu W, Xu WW, Fan J, Su L.

J Hepatol. 2015 Sep;63(3):622-33. doi: 10.1016/j.jhep.2015.04.010. Epub 2015 Apr 27.

PMID:
25931416
15.

Innate immune sensing of modified vaccinia virus Ankara (MVA) is mediated by TLR2-TLR6, MDA-5 and the NALP3 inflammasome.

Delaloye J, Roger T, Steiner-Tardivel QG, Le Roy D, Knaup Reymond M, Akira S, Petrilli V, Gomez CE, Perdiguero B, Tschopp J, Pantaleo G, Esteban M, Calandra T.

PLoS Pathog. 2009 Jun;5(6):e1000480. doi: 10.1371/journal.ppat.1000480. Epub 2009 Jun 19.

16.

Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors.

Babelova A, Moreth K, Tsalastra-Greul W, Zeng-Brouwers J, Eickelberg O, Young MF, Bruckner P, Pfeilschifter J, Schaefer RM, Gröne HJ, Schaefer L.

J Biol Chem. 2009 Sep 4;284(36):24035-48. doi: 10.1074/jbc.M109.014266. Epub 2009 Jul 15.

17.

Contribution of TIR domain-containing adapter inducing IFN-beta-mediated IL-18 release to LPS-induced liver injury in mice.

Imamura M, Tsutsui H, Yasuda K, Uchiyama R, Yumikura-Futatsugi S, Mitani K, Hayashi S, Akira S, Taniguchi S, Van Rooijen N, Tschopp J, Yamamoto T, Fujimoto J, Nakanishi K.

J Hepatol. 2009 Aug;51(2):333-41. doi: 10.1016/j.jhep.2009.03.027. Epub 2009 May 20.

PMID:
19501931
18.

Chemical stimulation of the intracranial dura activates NALP3 inflammasome in trigeminal ganglia neurons.

Chen L, Li X, Huang L, Wu Q, Chen L, Wan Q.

Brain Res. 2014 May 30;1566:1-11. doi: 10.1016/j.brainres.2014.04.019. Epub 2014 Apr 23.

PMID:
24769167
19.

Expression and function of the NALP3 inflammasome in rheumatoid synovium.

Kolly L, Busso N, Palmer G, Talabot-Ayer D, Chobaz V, So A.

Immunology. 2010 Feb;129(2):178-85. doi: 10.1111/j.1365-2567.2009.03174.x. Epub 2009 Aug 17.

20.

Activation of the Nlrp3 inflammasome by Streptococcus pyogenes requires streptolysin O and NF-kappa B activation but proceeds independently of TLR signaling and P2X7 receptor.

Harder J, Franchi L, Muñoz-Planillo R, Park JH, Reimer T, Núñez G.

J Immunol. 2009 Nov 1;183(9):5823-9. doi: 10.4049/jimmunol.0900444. Epub 2009 Oct 7.

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