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Items: 1 to 20 of 106

1.

Ggamma1, a downstream target for the hmgcr-isoprenoid biosynthetic pathway, is required for releasing the Hedgehog ligand and directing germ cell migration.

Deshpande G, Godishala A, Schedl P.

PLoS Genet. 2009 Jan;5(1):e1000333. doi: 10.1371/journal.pgen.1000333. Epub 2009 Jan 9.

2.

The hedgehog pathway gene shifted functions together with the hmgcr-dependent isoprenoid biosynthetic pathway to orchestrate germ cell migration.

Deshpande G, Zhou K, Wan JY, Friedrich J, Jourjine N, Smith D, Schedl P.

PLoS Genet. 2013;9(9):e1003720. doi: 10.1371/journal.pgen.1003720. Epub 2013 Sep 12.

3.

HMGCoA reductase potentiates hedgehog signaling in Drosophila melanogaster.

Deshpande G, Schedl P.

Dev Cell. 2005 Nov;9(5):629-38.

4.

Hedgehog does not guide migrating Drosophila germ cells.

Renault AD, Ricardo S, Kunwar PS, Santos A, Starz-Gaiano M, Stein JA, Lehmann R.

Dev Biol. 2009 Apr 15;328(2):355-62. doi: 10.1016/j.ydbio.2009.01.042. Epub 2009 Feb 6.

5.

Cells on the move: Modulation of guidance cues during germ cell migration.

Deshpande G, Barr J, Gerlitz O, Lebedeva L, Shidlovskii Y, Schedl P.

Fly (Austin). 2017 Jul 3;11(3):200-207. doi: 10.1080/19336934.2017.1304332. Epub 2017 Mar 16.

PMID:
28300473
6.

Role of lipid metabolism in smoothened derepression in hedgehog signaling.

Yavari A, Nagaraj R, Owusu-Ansah E, Folick A, Ngo K, Hillman T, Call G, Rohatgi R, Scott MP, Banerjee U.

Dev Cell. 2010 Jul 20;19(1):54-65. doi: 10.1016/j.devcel.2010.06.007.

7.

Role of the ABC transporter Mdr49 in Hedgehog signaling and germ cell migration.

Deshpande G, Manry D, Jourjine N, Mogila V, Mozes H, Bialistoky T, Gerlitz O, Schedl P.

Development. 2016 Jun 15;143(12):2111-20. doi: 10.1242/dev.133587. Epub 2016 Apr 27.

8.

Isoprenoids control germ cell migration downstream of HMGCoA reductase.

Santos AC, Lehmann R.

Dev Cell. 2004 Feb;6(2):283-93.

9.

The mevalonate pathway controls heart formation in Drosophila by isoprenylation of Ggamma1.

Yi P, Han Z, Li X, Olson EN.

Science. 2006 Sep 1;313(5791):1301-3. Epub 2006 Jul 20.

10.

Drosophila Vps36 regulates Smo trafficking in Hedgehog signaling.

Yang X, Mao F, Lv X, Zhang Z, Fu L, Lu Y, Wu W, Zhou Z, Zhang L, Zhao Y.

J Cell Sci. 2013 Sep 15;126(Pt 18):4230-8. doi: 10.1242/jcs.128603. Epub 2013 Jul 10.

11.

PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation.

Jia H, Liu Y, Yan W, Jia J.

Development. 2009 Jan;136(2):307-16. doi: 10.1242/dev.030015. Epub 2008 Dec 15.

12.

Hedgehog-regulated atypical PKC promotes phosphorylation and activation of Smoothened and Cubitus interruptus in Drosophila.

Jiang K, Liu Y, Fan J, Epperly G, Gao T, Jiang J, Jia J.

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):E4842-50. doi: 10.1073/pnas.1417147111. Epub 2014 Oct 27.

13.
14.

Drosophila miR-5 suppresses Hedgehog signaling by directly targeting Smoothened.

Wu LF, Gao L, Hou XM, Zhang QH, Li S, Yang YF, Lin XH.

FEBS Lett. 2012 Nov 16;586(22):4052-60. doi: 10.1016/j.febslet.2012.10.008. Epub 2012 Oct 16.

15.

Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila.

Li S, Chen Y, Shi Q, Yue T, Wang B, Jiang J.

PLoS Biol. 2012 Jan;10(1):e1001239. doi: 10.1371/journal.pbio.1001239. Epub 2012 Jan 10.

16.

Casein kinase 2 promotes Hedgehog signaling by regulating both smoothened and Cubitus interruptus.

Jia H, Liu Y, Xia R, Tong C, Yue T, Jiang J, Jia J.

J Biol Chem. 2010 Nov 26;285(48):37218-26. doi: 10.1074/jbc.M110.174565. Epub 2010 Sep 27.

17.

The extracellular loops of Smoothened play a regulatory role in control of Hedgehog pathway activation.

Carroll CE, Marada S, Stewart DP, Ouyang JX, Ogden SK.

Development. 2012 Feb;139(3):612-21. doi: 10.1242/dev.075614. Erratum in: Development. 2012 Feb;139(4):827.

18.

G-protein gamma subunit 1 is required for sugar reception in Drosophila.

Ishimoto H, Takahashi K, Ueda R, Tanimura T.

EMBO J. 2005 Sep 21;24(18):3259-65. Epub 2005 Aug 25. Erratum in: EMBO J. 2005 Oct 5;24(19):3516.

19.

A screen for modifiers of hedgehog signaling in Drosophila melanogaster identifies swm and mts.

Casso DJ, Liu S, Iwaki DD, Ogden SK, Kornberg TB.

Genetics. 2008 Mar;178(3):1399-413. doi: 10.1534/genetics.107.081638. Epub 2008 Feb 3.

20.

Smoothened oligomerization/higher order clustering in lipid rafts is essential for high Hedgehog activity transduction.

Shi D, Lv X, Zhang Z, Yang X, Zhou Z, Zhang L, Zhao Y.

J Biol Chem. 2013 May 3;288(18):12605-14. doi: 10.1074/jbc.M112.399477. Epub 2013 Mar 26.

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