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Impaired Bub1 function in vivo compromises tension-dependent checkpoint function leading to aneuploidy and tumorigenesis.

Schliekelman M, Cowley DO, O'Quinn R, Oliver TG, Lu L, Salmon ED, Van Dyke T.

Cancer Res. 2009 Jan 1;69(1):45-54. doi: 10.1158/0008-5472.CAN-07-6330.


Loss of BubR1 acetylation causes defects in spindle assembly checkpoint signaling and promotes tumor formation.

Park I, Lee HO, Choi E, Lee YK, Kwon MS, Min J, Park PG, Lee S, Kong YY, Gong G, Lee H.

J Cell Biol. 2013 Jul 22;202(2):295-309. doi: 10.1083/jcb.201210099.


Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis.

Jeganathan K, Malureanu L, Baker DJ, Abraham SC, van Deursen JM.

J Cell Biol. 2007 Oct 22;179(2):255-67. Epub 2007 Oct 15.


BubR1 is a spindle assembly checkpoint protein regulating meiotic cell cycle progression of mouse oocyte.

Wei L, Liang XW, Zhang QH, Li M, Yuan J, Li S, Sun SC, Ouyang YC, Schatten H, Sun QY.

Cell Cycle. 2010 Mar 15;9(6):1112-21. Epub 2010 Mar 15.


Different spindle checkpoint proteins monitor microtubule attachment and tension at kinetochores in Drosophila cells.

Logarinho E, Bousbaa H, Dias JM, Lopes C, Amorim I, Antunes-Martins A, Sunkel CE.

J Cell Sci. 2004 Apr 1;117(Pt 9):1757-71. Epub 2004 Mar 16.


Dissecting the roles of human BUB1 in the spindle assembly checkpoint.

Vleugel M, Hoek TA, Tromer E, Sliedrecht T, Groenewold V, Omerzu M, Kops GJ.

J Cell Sci. 2015 Aug 15;128(16):2975-82. doi: 10.1242/jcs.169821. Epub 2015 Jul 6.


Bub1 and aurora B cooperate to maintain BubR1-mediated inhibition of APC/CCdc20.

Morrow CJ, Tighe A, Johnson VL, Scott MI, Ditchfield C, Taylor SS.

J Cell Sci. 2005 Aug 15;118(Pt 16):3639-52. Epub 2005 Jul 26.


Bub1 kinase targets Sgo1 to ensure efficient chromosome biorientation in budding yeast mitosis.

Fernius J, Hardwick KG.

PLoS Genet. 2007 Nov;3(11):e213. Epub 2007 Oct 15.


Distinct domains in Bub1 localize RZZ and BubR1 to kinetochores to regulate the checkpoint.

Zhang G, Lischetti T, Hayward DG, Nilsson J.

Nat Commun. 2015 Jun 2;6:7162. doi: 10.1038/ncomms8162.


Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression.

Ricke RM, Jeganathan KB, Malureanu L, Harrison AM, van Deursen JM.

J Cell Biol. 2012 Dec 10;199(6):931-49. doi: 10.1083/jcb.201205115. Epub 2012 Dec 3.


The multiple roles of Bub1 in chromosome segregation during mitosis and meiosis.

Marchetti F, Venkatachalam S.

Cell Cycle. 2010 Jan 1;9(1):58-63. Epub 2010 Jan 18.


Uncoupling of the spindle-checkpoint and chromosome-congression functions of BubR1.

Elowe S, Dulla K, Uldschmid A, Li X, Dou Z, Nigg EA.

J Cell Sci. 2010 Jan 1;123(Pt 1):84-94. doi: 10.1242/jcs.056507.


Mad2 and BubR1 function in a single checkpoint pathway that responds to a loss of tension.

Shannon KB, Canman JC, Salmon ED.

Mol Biol Cell. 2002 Oct;13(10):3706-19.


Mad2 and BubR1 modulates tumourigenesis and paclitaxel response in MKN45 gastric cancer cells.

Bargiela-Iparraguirre J, Prado-Marchal L, Pajuelo-Lozano N, Jiménez B, Perona R, Sánchez-Pérez I.

Cell Cycle. 2014;13(22):3590-601. doi: 10.4161/15384101.2014.962952.


Laterally attached kinetochores recruit the checkpoint protein Bub1, but satisfy the spindle checkpoint.

Shimogawa MM, Wargacki MM, Muller EG, Davis TN.

Cell Cycle. 2010 Sep 1;9(17):3619-28.


The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint.

Hauf S, Cole RW, LaTerra S, Zimmer C, Schnapp G, Walter R, Heckel A, van Meel J, Rieder CL, Peters JM.

J Cell Biol. 2003 Apr 28;161(2):281-94. Epub 2003 Apr 21.


The spindle assembly checkpoint is satisfied in the absence of interkinetochore tension during mitosis with unreplicated genomes.

O'Connell CB, Loncarek J, Hergert P, Kourtidis A, Conklin DS, Khodjakov A.

J Cell Biol. 2008 Oct 6;183(1):29-36. doi: 10.1083/jcb.200801038. Epub 2008 Sep 29.


Mutations in the essential spindle checkpoint gene bub1 cause chromosome missegregation and fail to block apoptosis in Drosophila.

Basu J, Bousbaa H, Logarinho E, Li Z, Williams BC, Lopes C, Sunkel CE, Goldberg ML.

J Cell Biol. 1999 Jul 12;146(1):13-28.


The Spindle Assembly Checkpoint Safeguards Genomic Integrity of Skeletal Muscle Satellite Cells.

Kollu S, Abou-Khalil R, Shen C, Brack AS.

Stem Cell Reports. 2015 Jun 9;4(6):1061-74. doi: 10.1016/j.stemcr.2015.04.006. Epub 2015 May 7.

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