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Items: 1 to 20 of 80

1.

A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN.

Rahdar M, Inoue T, Meyer T, Zhang J, Vazquez F, Devreotes PN.

Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):480-5. doi: 10.1073/pnas.0811212106. Epub 2008 Dec 29.

2.

Mechanism of human PTEN localization revealed by heterologous expression in Dictyostelium.

Nguyen HN, Afkari Y, Senoo H, Sesaki H, Devreotes PN, Iijima M.

Oncogene. 2014 Dec 11;33(50):5688-96. doi: 10.1038/onc.2013.507. Epub 2013 Dec 2.

3.

A mutant form of PTEN linked to autism.

Redfern RE, Daou MC, Li L, Munson M, Gericke A, Ross AH.

Protein Sci. 2010 Oct;19(10):1948-56. doi: 10.1002/pro.483.

4.

Molecular Features of Phosphatase and Tensin Homolog (PTEN) Regulation by C-terminal Phosphorylation.

Chen Z, Dempsey DR, Thomas SN, Hayward D, Bolduc DM, Cole PA.

J Biol Chem. 2016 Jul 1;291(27):14160-9. doi: 10.1074/jbc.M116.728980. Epub 2016 May 11.

5.

The C-terminal tail inhibitory phosphorylation sites of PTEN regulate its intrinsic catalytic activity and the kinetics of its binding to phosphatidylinositol-4,5-bisphosphate.

Chia YC, Catimel B, Lio DS, Ang CS, Peng B, Wu H, Zhu HJ, Cheng HC.

Arch Biochem Biophys. 2015 Dec 1;587:48-60. doi: 10.1016/j.abb.2015.10.004. Epub 2015 Oct 22.

PMID:
26471078
6.

Allosteric activation of PTEN phosphatase by phosphatidylinositol 4,5-bisphosphate.

Campbell RB, Liu F, Ross AH.

J Biol Chem. 2003 Sep 5;278(36):33617-20. Epub 2003 Jul 11.

7.

Membrane-binding and activation mechanism of PTEN.

Das S, Dixon JE, Cho W.

Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7491-6. Epub 2003 Jun 13.

8.

Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane.

Vazquez F, Matsuoka S, Sellers WR, Yanagida T, Ueda M, Devreotes PN.

Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3633-8. Epub 2006 Feb 28.

9.

The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif.

Walker SM, Leslie NR, Perera NM, Batty IH, Downes CP.

Biochem J. 2004 Apr 15;379(Pt 2):301-7.

10.

SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane.

Huang J, Yan J, Zhang J, Zhu S, Wang Y, Shi T, Zhu C, Chen C, Liu X, Cheng J, Mustelin T, Feng GS, Chen G, Yu J.

Nat Commun. 2012 Jun 19;3:911. doi: 10.1038/ncomms1919.

PMID:
22713753
11.

Catalysis by the tumor-suppressor enzymes PTEN and PTEN-L.

Johnston SB, Raines RT.

PLoS One. 2015 Jan 21;10(1):e0116898. doi: 10.1371/journal.pone.0116898. eCollection 2015.

12.
13.

Direct modification and activation of a nuclear receptor-PIPâ‚‚ complex by the inositol lipid kinase IPMK.

Blind RD, Suzawa M, Ingraham HA.

Sci Signal. 2012 Jun 19;5(229):ra44. doi: 10.1126/scisignal.2003111.

14.

Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase.

Chagpar RB, Links PH, Pastor MC, Furber LA, Hawrysh AD, Chamberlain MD, Anderson DH.

Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5471-6. doi: 10.1073/pnas.0908899107. Epub 2010 Mar 8.

15.

Ubiquitination of PTEN (phosphatase and tensin homolog) inhibits phosphatase activity and is enhanced by membrane targeting and hyperosmotic stress.

Maccario H, Perera NM, Gray A, Downes CP, Leslie NR.

J Biol Chem. 2010 Apr 23;285(17):12620-8. doi: 10.1074/jbc.M109.072280. Epub 2010 Feb 22.

16.

Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation.

Shan X, Czar MJ, Bunnell SC, Liu P, Liu Y, Schwartzberg PL, Wange RL.

Mol Cell Biol. 2000 Sep;20(18):6945-57.

17.

Defining the membrane-associated state of the PTEN tumor suppressor protein.

Lumb CN, Sansom MS.

Biophys J. 2013 Feb 5;104(3):613-21. doi: 10.1016/j.bpj.2012.12.002.

18.

Understanding PTEN regulation: PIP2, polarity and protein stability.

Leslie NR, Batty IH, Maccario H, Davidson L, Downes CP.

Oncogene. 2008 Sep 18;27(41):5464-76. doi: 10.1038/onc.2008.243. Review.

PMID:
18794881
20.

A voltage-sensing phosphatase, Ci-VSP, which shares sequence identity with PTEN, dephosphorylates phosphatidylinositol 4,5-bisphosphate.

Iwasaki H, Murata Y, Kim Y, Hossain MI, Worby CA, Dixon JE, McCormack T, Sasaki T, Okamura Y.

Proc Natl Acad Sci U S A. 2008 Jun 10;105(23):7970-5. doi: 10.1073/pnas.0803936105. Epub 2008 Jun 4.

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