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Items: 1 to 20 of 314

1.

Dimer disruption and monomer sequestration by alkyl tripeptides are successful strategies for inhibiting wild-type and multidrug-resistant mutated HIV-1 proteases.

Bannwarth L, Rose T, Dufau L, Vanderesse R, Dumond J, Jamart-Grégoire B, Pannecouque C, De Clercq E, Reboud-Ravaux M.

Biochemistry. 2009 Jan 20;48(2):379-87. doi: 10.1021/bi801422u.

PMID:
19105629
2.
3.

Disruption of the HIV-1 protease dimer with interface peptides: structural studies using NMR spectroscopy combined with [2-(13)C]-Trp selective labeling.

Frutos S, Rodriguez-Mias RA, Madurga S, Collinet B, Reboud-Ravaux M, Ludevid D, Giralt E.

Biopolymers. 2007;88(2):164-73.

PMID:
17236209
4.

Molecular dynamics simulations of HIV-1 protease monomer: Assembly of N-terminus and C-terminus into beta-sheet in water solution.

Yan MC, Sha Y, Wang J, Xiong XQ, Ren JH, Cheng MS.

Proteins. 2008 Feb 15;70(3):731-8.

PMID:
17729281
5.

Molecular tongs containing amino acid mimetic fragments: new inhibitors of wild-type and mutated HIV-1 protease dimerization.

Bannwarth L, Kessler A, Pèthe S, Collinet B, Merabet N, Boggetto N, Sicsic S, Reboud-Ravaux M, Ongeri S.

J Med Chem. 2006 Jul 27;49(15):4657-64.

PMID:
16854071
6.

Dimerization inhibitors of HIV-1 protease.

Boggetto N, Reboud-Ravaux M.

Biol Chem. 2002 Sep;383(9):1321-4. Review.

PMID:
12437124
7.

Potent inhibition of drug-resistant HIV protease variants by monoclonal antibodies.

Bartonová V, Král V, Sieglová I, Brynda J, Fábry M, Horejsí M, Kozísek M, Sasková KG, Konvalinka J, Sedlácek J, Rezácová P.

Antiviral Res. 2008 Jun;78(3):275-7. doi: 10.1016/j.antiviral.2008.01.009.

PMID:
18329737
8.

Molecular analysis of the HIV-1 resistance development: enzymatic activities, crystal structures, and thermodynamics of nelfinavir-resistant HIV protease mutants.

Kozísek M, Bray J, Rezácová P, Sasková K, Brynda J, Pokorná J, Mammano F, Rulísek L, Konvalinka J.

J Mol Biol. 2007 Dec 7;374(4):1005-16.

PMID:
17977555
9.

Multidrug resistance to HIV-1 protease inhibition requires cooperative coupling between distal mutations.

Ohtaka H, Schön A, Freire E.

Biochemistry. 2003 Nov 25;42(46):13659-66.

PMID:
14622012
10.

Folded monomer of HIV-1 protease.

Ishima R, Ghirlando R, Tözsér J, Gronenborn AM, Torchia DA, Louis JM.

J Biol Chem. 2001 Dec 28;276(52):49110-6.

12.

Hydrophilic peptides derived from the transframe region of Gag-Pol inhibit the HIV-1 protease.

Louis JM, Dyda F, Nashed NT, Kimmel AR, Davies DR.

Biochemistry. 1998 Feb 24;37(8):2105-10.

PMID:
9485357
13.

A modular approach to HIV-1 proteinase inhibitor design.

Uhlíková T, Konvalinka J, Pichová I, Soucek M, Kräusslich HG, Vondrásek J.

Biochem Biophys Res Commun. 1996 May 6;222(1):38-43.

PMID:
8630071
14.

Domain flexibility in retroviral proteases: structural implications for drug resistant mutations.

Rose RB, Craik CS, Stroud RM.

Biochemistry. 1998 Feb 24;37(8):2607-21.

PMID:
9485411
15.

The folding and dimerization of HIV-1 protease: evidence for a stable monomer from simulations.

Levy Y, Caflisch A, Onuchic JN, Wolynes PG.

J Mol Biol. 2004 Jun 25;340(1):67-79.

PMID:
15184023
16.

Unusual binding mode of an HIV-1 protease inhibitor explains its potency against multi-drug-resistant virus strains.

Weber J, Mesters JR, Lepsík M, Prejdová J, Svec M, Sponarová J, Mlcochová P, Skalická K, Strísovský K, Uhlíková T, Soucek M, Machala L, Stanková M, Vondrásek J, Klimkait T, Kraeusslich HG, Hilgenfeld R, Konvalinka J.

J Mol Biol. 2002 Dec 6;324(4):739-54.

PMID:
12460574
17.

Computational proteomics analysis of binding mechanisms and molecular signatures of the HIV-1 protease drugs.

Verkhivker G.

Artif Intell Med. 2009 Feb-Mar;45(2-3):197-206. doi: 10.1016/j.artmed.2008.08.011.

PMID:
18926674
18.

Anisotropic dynamics of the JE-2147-HIV protease complex: drug resistance and thermodynamic binding mode examined in a 1.09 A structure.

Reiling KK, Endres NF, Dauber DS, Craik CS, Stroud RM.

Biochemistry. 2002 Apr 9;41(14):4582-94.

PMID:
11926820
19.

Design, synthesis, and evaluation of conformationally constrained tongs, new inhibitors of HIV-1 protease dimerization.

Bouras A, Boggetto N, Benatalah Z, de Rosny E, Sicsic S, Reboud-Ravaux M.

J Med Chem. 1999 Mar 25;42(6):957-62.

PMID:
10090778

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