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UAF1 is a subunit of multiple deubiquitinating enzyme complexes.

Cohn MA, Kee Y, Haas W, Gygi SP, D'Andrea AD.

J Biol Chem. 2009 Feb 20;284(8):5343-51. doi: 10.1074/jbc.M808430200. Epub 2008 Dec 15.


WDR20 regulates activity of the USP12 x UAF1 deubiquitinating enzyme complex.

Kee Y, Yang K, Cohn MA, Haas W, Gygi SP, D'Andrea AD.

J Biol Chem. 2010 Apr 9;285(15):11252-7. doi: 10.1074/jbc.M109.095141. Epub 2010 Feb 10.


A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway.

Cohn MA, Kowal P, Yang K, Haas W, Huang TT, Gygi SP, D'Andrea AD.

Mol Cell. 2007 Dec 14;28(5):786-97.


The USP1/UAF1 complex promotes double-strand break repair through homologous recombination.

Murai J, Yang K, Dejsuphong D, Hirota K, Takeda S, D'Andrea AD.

Mol Cell Biol. 2011 Jun;31(12):2462-9. doi: 10.1128/MCB.05058-11. Epub 2011 Apr 11.


E1-mediated recruitment of a UAF1-USP deubiquitinase complex facilitates human papillomavirus DNA replication.

Lehoux M, Gagnon D, Archambault J.

J Virol. 2014 Aug;88(15):8545-55. doi: 10.1128/JVI.00379-14. Epub 2014 May 21.


The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway.

Nijman SM, Huang TT, Dirac AM, Brummelkamp TR, Kerkhoven RM, D'Andrea AD, Bernards R.

Mol Cell. 2005 Feb 4;17(3):331-9.


Human ELG1 regulates the level of ubiquitinated proliferating cell nuclear antigen (PCNA) through Its interactions with PCNA and USP1.

Lee KY, Yang K, Cohn MA, Sikdar N, D'Andrea AD, Myung K.

J Biol Chem. 2010 Apr 2;285(14):10362-9. doi: 10.1074/jbc.M109.092544. Epub 2010 Feb 9.


Serine phosphorylation is critical for the activation of ubiquitin-specific protease 1 and its interaction with WD40-repeat protein UAF1.

Villamil MA, Liang Q, Chen J, Choi YS, Hou S, Lee KH, Zhuang Z.

Biochemistry. 2012 Nov 13;51(45):9112-23. doi: 10.1021/bi300845s. Epub 2012 Nov 1.


Regulation of the Fanconi anemia pathway by a SUMO-like delivery network.

Yang K, Moldovan GL, Vinciguerra P, Murai J, Takeda S, D'Andrea AD.

Genes Dev. 2011 Sep 1;25(17):1847-58. doi: 10.1101/gad.17020911.


Two nuclear localization signals in USP1 mediate nuclear import of the USP1/UAF1 complex.

Garcia-Santisteban I, Zorroza K, Rodriguez JA.

PLoS One. 2012;7(6):e38570. doi: 10.1371/journal.pone.0038570. Epub 2012 Jun 6.


Inactivation of Uaf1 causes defective homologous recombination and early embryonic lethality in mice.

Park E, Kim JM, Primack B, Weinstock DM, Moreau LA, Parmar K, D'Andrea AD.

Mol Cell Biol. 2013 Nov;33(22):4360-70. doi: 10.1128/MCB.00870-13. Epub 2013 Sep 3.


Deubiquitination of FANCD2 is required for DNA crosslink repair.

Oestergaard VH, Langevin F, Kuiken HJ, Pace P, Niedzwiedz W, Simpson LJ, Ohzeki M, Takata M, Sale JE, Patel KJ.

Mol Cell. 2007 Dec 14;28(5):798-809.


Hematopoietic stem cell defects in mice with deficiency of Fancd2 or Usp1.

Parmar K, Kim J, Sykes SM, Shimamura A, Stuckert P, Zhu K, Hamilton A, Deloach MK, Kutok JL, Akashi K, Gilliland DG, D'andrea A.

Stem Cells. 2010 Jul;28(7):1186-95. doi: 10.1002/stem.437.


Structure-function analysis of USP1: insights into the role of Ser313 phosphorylation site and the effect of cancer-associated mutations on autocleavage.

Olazabal-Herrero A, García-Santisteban I, Rodríguez JA.

Mol Cancer. 2015 Feb 6;14:33. doi: 10.1186/s12943-015-0311-7.


Selective and cell-active inhibitors of the USP1/ UAF1 deubiquitinase complex reverse cisplatin resistance in non-small cell lung cancer cells.

Chen J, Dexheimer TS, Ai Y, Liang Q, Villamil MA, Inglese J, Maloney DJ, Jadhav A, Simeonov A, Zhuang Z.

Chem Biol. 2011 Nov 23;18(11):1390-400. doi: 10.1016/j.chembiol.2011.08.014.


A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses.

Liang Q, Dexheimer TS, Zhang P, Rosenthal AS, Villamil MA, You C, Zhang Q, Chen J, Ott CA, Sun H, Luci DK, Yuan B, Simeonov A, Jadhav A, Xiao H, Wang Y, Maloney DJ, Zhuang Z.

Nat Chem Biol. 2014 Apr;10(4):298-304. doi: 10.1038/nchembio.1455. Epub 2014 Feb 16.


Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype.

Kim JM, Parmar K, Huang M, Weinstock DM, Ruit CA, Kutok JL, D'Andrea AD.

Dev Cell. 2009 Feb;16(2):314-20. doi: 10.1016/j.devcel.2009.01.001.


Regulation of histone H2A and H2B deubiquitination and Xenopus development by USP12 and USP46.

Joo HY, Jones A, Yang C, Zhai L, Smith AD 4th, Zhang Z, Chandrasekharan MB, Sun ZW, Renfrow MB, Wang Y, Chang C, Wang H.

J Biol Chem. 2011 Mar 4;286(9):7190-201. doi: 10.1074/jbc.M110.158311. Epub 2010 Dec 23.


USP1 deubiquitinase maintains phosphorylated CHK1 by limiting its DDB1-dependent degradation.

Guervilly JH, Renaud E, Takata M, Rosselli F.

Hum Mol Genet. 2011 Jun 1;20(11):2171-81. doi: 10.1093/hmg/ddr103. Epub 2011 Mar 9.

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