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Items: 1 to 20 of 89


TLR-independent type I interferon induction in response to an extracellular bacterial pathogen via intracellular recognition of its DNA.

Charrel-Dennis M, Latz E, Halmen KA, Trieu-Cuot P, Fitzgerald KA, Kasper DL, Golenbock DT.

Cell Host Microbe. 2008 Dec 11;4(6):543-54. doi: 10.1016/j.chom.2008.11.002.


Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response.

Oganesyan G, Saha SK, Guo B, He JQ, Shahangian A, Zarnegar B, Perry A, Cheng G.

Nature. 2006 Jan 12;439(7073):208-11. Epub 2005 Nov 23.


Protein phosphatase PP1 negatively regulates the Toll-like receptor- and RIG-I-like receptor-triggered production of type I interferon by inhibiting IRF3 phosphorylation at serines 396 and 385 in macrophage.

Gu M, Zhang T, lin W, Liu Z, Lai R, Xia D, Huang H, Wang X.

Cell Signal. 2014 Dec;26(12):2930-9. doi: 10.1016/j.cellsig.2014.09.007. Epub 2014 Sep 17.


A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.

Ishii KJ, Coban C, Kato H, Takahashi K, Torii Y, Takeshita F, Ludwig H, Sutter G, Suzuki K, Hemmi H, Sato S, Yamamoto M, Uematsu S, Kawai T, Takeuchi O, Akira S.

Nat Immunol. 2006 Jan;7(1):40-8. Epub 2005 Nov 13. Erratum in: Nat Immunol. 2006 Apr;7(4):427.


Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways.

Henneke P, Takeuchi O, Malley R, Lien E, Ingalls RR, Freeman MW, Mayadas T, Nizet V, Akira S, Kasper DL, Golenbock DT.

J Immunol. 2002 Oct 1;169(7):3970-7.


CaMKII promotes TLR-triggered proinflammatory cytokine and type I interferon production by directly binding and activating TAK1 and IRF3 in macrophages.

Liu X, Yao M, Li N, Wang C, Zheng Y, Cao X.

Blood. 2008 Dec 15;112(13):4961-70. doi: 10.1182/blood-2008-03-144022. Epub 2008 Sep 25.


IFN regulatory factor 3-dependent induction of type I IFNs by intracellular bacteria is mediated by a TLR- and Nod2-independent mechanism.

Stockinger S, Reutterer B, Schaljo B, Schellack C, Brunner S, Materna T, Yamamoto M, Akira S, Taniguchi T, Murray PJ, Müller M, Decker T.

J Immunol. 2004 Dec 15;173(12):7416-25.


Type I interferon production induced by Streptococcus pyogenes-derived nucleic acids is required for host protection.

Gratz N, Hartweger H, Matt U, Kratochvill F, Janos M, Sigel S, Drobits B, Li XD, Knapp S, Kovarik P.

PLoS Pathog. 2011 May;7(5):e1001345. doi: 10.1371/journal.ppat.1001345. Epub 2011 May 19.


Streptococcus pneumoniae DNA initiates type I interferon signaling in the respiratory tract.

Parker D, Martin FJ, Soong G, Harfenist BS, Aguilar JL, Ratner AJ, Fitzgerald KA, Schindler C, Prince A.

MBio. 2011 May 17;2(3):e00016-11. doi: 10.1128/mBio.00016-11. Print 2011.


TRAF-interacting protein (TRIP) negatively regulates IFN-β production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1.

Zhang M, Wang L, Zhao X, Zhao K, Meng H, Zhao W, Gao C.

J Exp Med. 2012 Sep 24;209(10):1703-11. Epub 2012 Sep 3.


Toll-like receptor 2-dependent and -independent activation of macrophages by group B streptococci.

Draper DW, Bethea HN, He YW.

Immunol Lett. 2006 Feb 15;102(2):202-14. Epub 2005 Oct 6.


Adenovirus induction of IRF3 occurs through a binary trigger targeting Jun N-terminal kinase and TBK1 kinase cascades and type I interferon autocrine signaling.

Nociari M, Ocheretina O, Murphy M, Falck-Pedersen E.

J Virol. 2009 May;83(9):4081-91. doi: 10.1128/JVI.02591-08. Epub 2009 Feb 11.


RIOK3 is an adaptor protein required for IRF3-mediated antiviral type I interferon production.

Feng J, De Jesus PD, Su V, Han S, Gong D, Wu NC, Tian Y, Li X, Wu TT, Chanda SK, Sun R.

J Virol. 2014 Jul;88(14):7987-97. doi: 10.1128/JVI.00643-14. Epub 2014 May 7.


Role of Toll-like receptor 13 in innate immune recognition of group B streptococci.

Signorino G, Mohammadi N, Patanè F, Buscetta M, Venza M, Venza I, Mancuso G, Midiri A, Alexopoulou L, Teti G, Biondo C, Beninati C.

Infect Immun. 2014 Dec;82(12):5013-22. doi: 10.1128/IAI.02282-14. Epub 2014 Sep 15.


SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine production.

An H, Zhao W, Hou J, Zhang Y, Xie Y, Zheng Y, Xu H, Qian C, Zhou J, Yu Y, Liu S, Feng G, Cao X.

Immunity. 2006 Dec;25(6):919-28. Epub 2006 Dec 7.


DOK3 is required for IFN-β production by enabling TRAF3/TBK1 complex formation and IRF3 activation.

Kim SS, Lee KG, Chin CS, Ng SK, Pereira NA, Xu S, Lam KP.

J Immunol. 2014 Jul 15;193(2):840-8. doi: 10.4049/jimmunol.1301601. Epub 2014 Jun 13.


Mycobacterium tuberculosis activates the DNA-dependent cytosolic surveillance pathway within macrophages.

Manzanillo PS, Shiloh MU, Portnoy DA, Cox JS.

Cell Host Microbe. 2012 May 17;11(5):469-80. doi: 10.1016/j.chom.2012.03.007.


NOD2, RIP2 and IRF5 play a critical role in the type I interferon response to Mycobacterium tuberculosis.

Pandey AK, Yang Y, Jiang Z, Fortune SM, Coulombe F, Behr MA, Fitzgerald KA, Sassetti CM, Kelliher MA.

PLoS Pathog. 2009 Jul;5(7):e1000500. doi: 10.1371/journal.ppat.1000500. Epub 2009 Jul 3.

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