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Items: 1 to 20 of 106

1.

SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging.

Oberdoerffer P, Michan S, McVay M, Mostoslavsky R, Vann J, Park SK, Hartlerode A, Stegmuller J, Hafner A, Loerch P, Wright SM, Mills KD, Bonni A, Yankner BA, Scully R, Prolla TA, Alt FW, Sinclair DA.

Cell. 2008 Nov 28;135(5):907-18. doi: 10.1016/j.cell.2008.10.025.

2.

Aging: a sirtuin shake-up?

Vijg J, Maslov AY, Suh Y.

Cell. 2008 Nov 28;135(5):797-8. doi: 10.1016/j.cell.2008.11.008.

3.

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.

Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, Liu P, Mostoslavsky G, Franco S, Murphy MM, Mills KD, Patel P, Hsu JT, Hong AL, Ford E, Cheng HL, Kennedy C, Nunez N, Bronson R, Frendewey D, Auerbach W, Valenzuela D, Karow M, Hottiger MO, Hursting S, Barrett JC, Guarente L, Mulligan R, Demple B, Yancopoulos GD, Alt FW.

Cell. 2006 Jan 27;124(2):315-29.

4.

SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair.

McCord RA, Michishita E, Hong T, Berber E, Boxer LD, Kusumoto R, Guan S, Shi X, Gozani O, Burlingame AL, Bohr VA, Chua KF.

Aging (Albany NY). 2009 Jan 15;1(1):109-21.

5.

Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice.

Wang RH, Sengupta K, Li C, Kim HS, Cao L, Xiao C, Kim S, Xu X, Zheng Y, Chilton B, Jia R, Zheng ZM, Appella E, Wang XW, Ried T, Deng CX.

Cancer Cell. 2008 Oct 7;14(4):312-23. doi: 10.1016/j.ccr.2008.09.001.

6.

Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation.

Li K, Casta A, Wang R, Lozada E, Fan W, Kane S, Ge Q, Gu W, Orren D, Luo J.

J Biol Chem. 2008 Mar 21;283(12):7590-8. doi: 10.1074/jbc.M709707200. Epub 2008 Jan 17.

7.

Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses.

Chen WY, Wang DH, Yen RC, Luo J, Gu W, Baylin SB.

Cell. 2005 Nov 4;123(3):437-48.

8.

Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress.

Chua KF, Mostoslavsky R, Lombard DB, Pang WW, Saito S, Franco S, Kaushal D, Cheng HL, Fischer MR, Stokes N, Murphy MM, Appella E, Alt FW.

Cell Metab. 2005 Jul;2(1):67-76. Erratum in: Cell Metab. 2006 Jan;3(1):75.

9.

Sirt1 regulates aging and resistance to oxidative stress in the heart.

Alcendor RR, Gao S, Zhai P, Zablocki D, Holle E, Yu X, Tian B, Wagner T, Vatner SF, Sadoshima J.

Circ Res. 2007 May 25;100(10):1512-21. Epub 2007 Apr 19.

10.

Functional interplay between Parp-1 and SirT1 in genome integrity and chromatin-based processes.

El Ramy R, Magroun N, Messadecq N, Gauthier LR, Boussin FD, Kolthur-Seetharam U, Schreiber V, McBurney MW, Sassone-Corsi P, Dantzer F.

Cell Mol Life Sci. 2009 Oct;66(19):3219-34. doi: 10.1007/s00018-009-0105-4. Epub 2009 Aug 12.

PMID:
19672559
11.

SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons.

Dobbin MM, Madabhushi R, Pan L, Chen Y, Kim D, Gao J, Ahanonu B, Pao PC, Qiu Y, Zhao Y, Tsai LH.

Nat Neurosci. 2013 Aug;16(8):1008-15. doi: 10.1038/nn.3460. Epub 2013 Jul 14.

12.

Linking sirtuins, IGF-I signaling, and starvation.

Longo VD.

Exp Gerontol. 2009 Jan-Feb;44(1-2):70-4. doi: 10.1016/j.exger.2008.06.005. Epub 2008 Jun 24. Review.

PMID:
18638538
13.

Effects of hyperglycemia and aging on nuclear sirtuins and DNA damage of mouse hepatocytes.

Ghiraldini FG, Crispim AC, Mello ML.

Mol Biol Cell. 2013 Aug;24(15):2467-76. doi: 10.1091/mbc.E13-04-0186. Epub 2013 Jun 12.

14.

Sirt1 ablation promotes stress-induced loss of epigenetic and genomic hematopoietic stem and progenitor cell maintenance.

Singh SK, Williams CA, Klarmann K, Burkett SS, Keller JR, Oberdoerffer P.

J Exp Med. 2013 May 6;210(5):987-1001. doi: 10.1084/jem.20121608. Epub 2013 Apr 29.

15.

Chromosomal characterization and localization of the NAD+-dependent histone deacetylase gene sirtuin 1 in the mouse.

Mahlknecht U, Voelter-Mahlknecht S.

Int J Mol Med. 2009 Feb;23(2):245-52.

PMID:
19148549
16.

SIRT1: tumor promoter or tumor suppressor?

Lim CS.

Med Hypotheses. 2006;67(2):341-4. Epub 2006 Mar 20.

PMID:
16546327
17.

SIRT1 contributes to telomere maintenance and augments global homologous recombination.

Palacios JA, Herranz D, De Bonis ML, Velasco S, Serrano M, Blasco MA.

J Cell Biol. 2010 Dec 27;191(7):1299-313. doi: 10.1083/jcb.201005160.

18.

SIRT1: roles in aging and cancer.

Kim EJ, Um SJ.

BMB Rep. 2008 Nov 30;41(11):751-6. Review.

19.

SIRT6 recruits SNF2H to DNA break sites, preventing genomic instability through chromatin remodeling.

Toiber D, Erdel F, Bouazoune K, Silberman DM, Zhong L, Mulligan P, Sebastian C, Cosentino C, Martinez-Pastor B, Giacosa S, D'Urso A, Näär AM, Kingston R, Rippe K, Mostoslavsky R.

Mol Cell. 2013 Aug 22;51(4):454-68. doi: 10.1016/j.molcel.2013.06.018. Epub 2013 Aug 1.

20.

Repairing split ends: SIRT6, mono-ADP ribosylation and DNA repair.

Van Meter M, Mao Z, Gorbunova V, Seluanov A.

Aging (Albany NY). 2011 Sep;3(9):829-35. Review.

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