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Items: 1 to 20 of 290

1.

Human ether-a-go-go related gene (hERG) K+ channels: function and dysfunction.

Perrin MJ, Subbiah RN, Vandenberg JI, Hill AP.

Prog Biophys Mol Biol. 2008 Oct-Nov;98(2-3):137-48. doi: 10.1016/j.pbiomolbio.2008.10.006. Epub 2008 Nov 5. Review.

PMID:
19027781
2.

[HERG K+ channel, the target of anti-arrhythmias drugs].

Guan FY, Yang SJ.

Yao Xue Xue Bao. 2007 Jul;42(7):687-91. Review. Chinese.

PMID:
17882949
3.
4.

hERG potassium channels and cardiac arrhythmia.

Sanguinetti MC, Tristani-Firouzi M.

Nature. 2006 Mar 23;440(7083):463-9. Review.

PMID:
16554806
5.
6.

[Progress in research on defective protein trafficking and functional restoration in HERG-associated long QT syndrome].

Fang P, Lian J.

Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2016 Feb;33(1):101-4. doi: 10.3760/cma.j.issn.1003-9406.2016.01.024. Review. Chinese.

PMID:
26829745
7.

HERG trafficking and pharmacological rescue of LQTS-2 mutant channels.

Robertson GA, January CT.

Handb Exp Pharmacol. 2006;(171):349-55. Review.

PMID:
16610352
8.

Activation of human ether-a-go-go related gene (hERG) potassium channels by small molecules.

Zhou PZ, Babcock J, Liu LQ, Li M, Gao ZB.

Acta Pharmacol Sin. 2011 Jun;32(6):781-8. doi: 10.1038/aps.2011.70. Epub 2011 May 30. Review.

9.

Identification and functional characterization of the human ether-a-go-go-related gene Q738X mutant associated with hereditary long QT syndrome type 2.

Han SN, Yang SH, Zhang Y, Sun XY, Duan YY, Hu XJ, Fan TL, Huang CZ, Yang G, Zhang Z, Zhang L.

Int J Mol Med. 2014 Sep;34(3):810-5. doi: 10.3892/ijmm.2014.1827. Epub 2014 Jul 1.

PMID:
24993425
10.

A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channels.

Gustina AS, Trudeau MC.

Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):13082-7. doi: 10.1073/pnas.0900180106. Epub 2009 Jul 27.

11.

Fever-induced QTc prolongation and ventricular arrhythmias in individuals with type 2 congenital long QT syndrome.

Amin AS, Herfst LJ, Delisle BP, Klemens CA, Rook MB, Bezzina CR, Underkofler HA, Holzem KM, Ruijter JM, Tan HL, January CT, Wilde AA.

J Clin Invest. 2008 Jul;118(7):2552-61. doi: 10.1172/JCI35337.

12.

The Susceptibilities of Human Ether-à-Go-Go-Related Gene Channel with the G487R Mutation to Arrhythmogenic Factors.

Hisajima N, Hata Y, Kinoshita K, Fukushima T, Nishida N, Kano M, Tabata T.

Biol Pharm Bull. 2015;38(5):781-4. doi: 10.1248/bpb.b14-00630.

13.

Familial and acquired long qt syndrome and the cardiac rapid delayed rectifier potassium current.

Witchel HJ, Hancox JC.

Clin Exp Pharmacol Physiol. 2000 Oct;27(10):753-66. Review.

PMID:
11022966
14.

Translational toxicology and rescue strategies of the hERG channel dysfunction: biochemical and molecular mechanistic aspects.

Zhang KP, Yang BF, Li BX.

Acta Pharmacol Sin. 2014 Dec;35(12):1473-84. doi: 10.1038/aps.2014.101. Epub 2014 Nov 24. Review.

15.
16.

A splice site mutation in hERG leads to cryptic splicing in human long QT syndrome.

Gong Q, Zhang L, Moss AJ, Vincent GM, Ackerman MJ, Robinson JC, Jones MA, Tester DJ, Zhou Z.

J Mol Cell Cardiol. 2008 Mar;44(3):502-9. doi: 10.1016/j.yjmcc.2008.01.002. Epub 2008 Jan 17.

17.

A missense mutation (G604S) in the S5/pore region of HERG causes long QT syndrome in a Chinese family with a high incidence of sudden unexpected death.

Zhang Y, Zhou N, Jiang W, Peng J, Wan H, Huang C, Xie Z, Huang CL, Grace AA, Ma A.

Eur J Pediatr. 2007 Sep;166(9):927-33. Epub 2006 Dec 14.

PMID:
17171344
18.

Modulation of HERG potassium channel function by drug action.

Thomas D, Karle CA, Kiehn J.

Ann Med. 2004;36 Suppl 1:41-6.

PMID:
15176423
19.

Molecular determinants of cocaine block of human ether-á-go-go-related gene potassium channels.

Guo J, Gang H, Zhang S.

J Pharmacol Exp Ther. 2006 May;317(2):865-74. Epub 2006 Jan 5.

20.

Molecular mechanisms for drug interactions with hERG that cause long QT syndrome.

Stansfeld PJ, Sutcliffe MJ, Mitcheson JS.

Expert Opin Drug Metab Toxicol. 2006 Feb;2(1):81-94. Review.

PMID:
16863470

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