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Items: 1 to 20 of 98

1.

Initiation and elongation in fibrillation of ALS-linked superoxide dismutase.

Chattopadhyay M, Durazo A, Sohn SH, Strong CD, Gralla EB, Whitelegge JP, Valentine JS.

Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18663-8. doi: 10.1073/pnas.0807058105. Epub 2008 Nov 20.

2.

The Disulfide Bond, but Not Zinc or Dimerization, Controls Initiation and Seeded Growth in Amyotrophic Lateral Sclerosis-linked Cu,Zn Superoxide Dismutase (SOD1) Fibrillation.

Chattopadhyay M, Nwadibia E, Strong CD, Gralla EB, Valentine JS, Whitelegge JP.

J Biol Chem. 2015 Dec 18;290(51):30624-36. doi: 10.1074/jbc.M115.666503. Epub 2015 Oct 28.

3.

A structural modeling approach for the understanding of initiation and elongation of ALS-linked superoxide dismutase fibrils.

Falconi M, Iacovelli F, Desideri A.

J Mol Model. 2013 Sep;19(9):3695-704. doi: 10.1007/s00894-013-1896-7. Epub 2013 Jun 19.

PMID:
23780345
4.

Loss of metal ions, disulfide reduction and mutations related to familial ALS promote formation of amyloid-like aggregates from superoxide dismutase.

Oztug Durer ZA, Cohlberg JA, Dinh P, Padua S, Ehrenclou K, Downes S, Tan JK, Nakano Y, Bowman CJ, Hoskins JL, Kwon C, Mason AZ, Rodriguez JA, Doucette PA, Shaw BF, Valentine JS.

PLoS One. 2009;4(3):e5004. doi: 10.1371/journal.pone.0005004. Epub 2009 Mar 27.

5.

Aggregation of copper-zinc superoxide dismutase in familial and sporadic ALS.

Chattopadhyay M, Valentine JS.

Antioxid Redox Signal. 2009 Jul;11(7):1603-14. doi: 10.1089/ARS.2009.2536. Review.

6.

Immature copper-zinc superoxide dismutase and familial amyotrophic lateral sclerosis.

Seetharaman SV, Prudencio M, Karch C, Holloway SP, Borchelt DR, Hart PJ.

Exp Biol Med (Maywood). 2009 Oct;234(10):1140-54. doi: 10.3181/0903-MR-104. Epub 2009 Jul 13. Review.

7.

Complete loss of post-translational modifications triggers fibrillar aggregation of SOD1 in the familial form of amyotrophic lateral sclerosis.

Furukawa Y, Kaneko K, Yamanaka K, O'Halloran TV, Nukina N.

J Biol Chem. 2008 Aug 29;283(35):24167-76. doi: 10.1074/jbc.M802083200. Epub 2008 Jun 13.

8.

Disulfide cross-linked protein represents a significant fraction of ALS-associated Cu, Zn-superoxide dismutase aggregates in spinal cords of model mice.

Furukawa Y, Fu R, Deng HX, Siddique T, O'Halloran TV.

Proc Natl Acad Sci U S A. 2006 May 2;103(18):7148-53. Epub 2006 Apr 24.

9.

Metal-free superoxide dismutase forms soluble oligomers under physiological conditions: a possible general mechanism for familial ALS.

Banci L, Bertini I, Durazo A, Girotto S, Gralla EB, Martinelli M, Valentine JS, Vieru M, Whitelegge JP.

Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11263-7. Epub 2007 Jun 25.

10.

Conformational Disorder of the Most Immature Cu, Zn-Superoxide Dismutase Leading to Amyotrophic Lateral Sclerosis.

Furukawa Y, Anzai I, Akiyama S, Imai M, Cruz FJ, Saio T, Nagasawa K, Nomura T, Ishimori K.

J Biol Chem. 2016 Feb 19;291(8):4144-55. doi: 10.1074/jbc.M115.683763. Epub 2015 Dec 22.

11.

Disruption of mitochondrial membrane integrity induced by amyloid aggregates arising from variants of SOD1.

Oladzad Abbasabadi A, Javanian A, Nikkhah M, Meratan AA, Ghiasi P, Nemat-Gorgani M.

Int J Biol Macromol. 2013 Oct;61:212-7. doi: 10.1016/j.ijbiomac.2013.07.007. Epub 2013 Jul 17.

PMID:
23872456
12.

Superoxide dismutase 1 and tgSOD1 mouse spinal cord seed fibrils, suggesting a propagative cell death mechanism in amyotrophic lateral sclerosis.

Chia R, Tattum MH, Jones S, Collinge J, Fisher EM, Jackson GS.

PLoS One. 2010 May 13;5(5):e10627. doi: 10.1371/journal.pone.0010627.

13.

Inducible superoxide dismutase 1 aggregation in transgenic amyotrophic lateral sclerosis mouse fibroblasts.

Turner BJ, Lopes EC, Cheema SS.

J Cell Biochem. 2004 Apr 1;91(5):1074-84.

PMID:
15034941
14.

Structural changes to monomeric CuZn superoxide dismutase caused by the familial amyotrophic lateral sclerosis-associated mutation A4V.

Schmidlin T, Kennedy BK, Daggett V.

Biophys J. 2009 Sep 16;97(6):1709-18. doi: 10.1016/j.bpj.2009.06.043.

15.

An intersubunit disulfide bond prevents in vitro aggregation of a superoxide dismutase-1 mutant linked to familial amytrophic lateral sclerosis.

Ray SS, Nowak RJ, Strokovich K, Brown RH Jr, Walz T, Lansbury PT Jr.

Biochemistry. 2004 May 4;43(17):4899-905.

PMID:
15109247
16.

Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1.

Atkin JD, Farg MA, Turner BJ, Tomas D, Lysaght JA, Nunan J, Rembach A, Nagley P, Beart PM, Cheema SS, Horne MK.

J Biol Chem. 2006 Oct 6;281(40):30152-65. Epub 2006 Jul 17.

17.

Mechanism for transforming cytosolic SOD1 into integral membrane proteins of organelles by ALS-causing mutations.

Lim L, Lee X, Song J.

Biochim Biophys Acta. 2015 Jan;1848(1 Pt A):1-7. doi: 10.1016/j.bbamem.2014.10.002. Epub 2014 Oct 12.

18.

Nonamyloid aggregates arising from mature copper/zinc superoxide dismutases resemble those observed in amyotrophic lateral sclerosis.

Hwang YM, Stathopulos PB, Dimmick K, Yang H, Badiei HR, Tong MS, Rumfeldt JA, Chen P, Karanassios V, Meiering EM.

J Biol Chem. 2010 Dec 31;285(53):41701-11. doi: 10.1074/jbc.M110.113696. Epub 2010 Oct 25.

19.

Structural consequences of the familial amyotrophic lateral sclerosis SOD1 mutant His46Arg.

Antonyuk S, Elam JS, Hough MA, Strange RW, Doucette PA, Rodriguez JA, Hayward LJ, Valentine JS, Hart PJ, Hasnain SS.

Protein Sci. 2005 May;14(5):1201-13.

20.

Structural similarity of wild-type and ALS-mutant superoxide dismutase-1 fibrils using limited proteolysis and atomic force microscopy.

Chan PK, Chattopadhyay M, Sharma S, Souda P, Gralla EB, Borchelt DR, Whitelegge JP, Valentine JS.

Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):10934-9. doi: 10.1073/pnas.1309613110. Epub 2013 Jun 18.

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