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The ribosomal stalk is required for ribosome binding, depurination of the rRNA and cytotoxicity of ricin A chain in Saccharomyces cerevisiae.

Chiou JC, Li XP, Remacha M, Ballesta JP, Tumer NE.

Mol Microbiol. 2008 Dec;70(6):1441-52. doi: 10.1111/j.1365-2958.2008.06492.x.


The P1/P2 proteins of the human ribosomal stalk are required for ribosome binding and depurination by ricin in human cells.

May KL, Li XP, Martínez-Azorín F, Ballesta JP, Grela P, Tchórzewski M, Tumer NE.

FEBS J. 2012 Oct;279(20):3925-36. doi: 10.1111/j.1742-4658.2012.08752.x.


Shiga toxin 1 is more dependent on the P proteins of the ribosomal stalk for depurination activity than Shiga toxin 2.

Chiou JC, Li XP, Remacha M, Ballesta JP, Tumer NE.

Int J Biochem Cell Biol. 2011 Dec;43(12):1792-801. doi: 10.1016/j.biocel.2011.08.018.


Ribosome depurination is not sufficient for ricin-mediated cell death in Saccharomyces cerevisiae.

Li XP, Baricevic M, Saidasan H, Tumer NE.

Infect Immun. 2007 Jan;75(1):417-28.


Functional divergence between the two P1-P2 stalk dimers on the ribosome in their interaction with ricin A chain.

Grela P, Li XP, Tchórzewski M, Tumer NE.

Biochem J. 2014 May 15;460(1):59-67. doi: 10.1042/BJ20140014.


Pentameric organization of the ribosomal stalk accelerates recruitment of ricin a chain to the ribosome for depurination.

Li XP, Grela P, Krokowski D, Tchórzewski M, Tumer NE.

J Biol Chem. 2010 Dec 31;285(53):41463-71. doi: 10.1074/jbc.M110.171793.


Generation of pokeweed antiviral protein mutations in Saccharomyces cerevisiae: evidence that ribosome depurination is not sufficient for cytotoxicity.

Hudak KA, Parikh BA, Di R, Baricevic M, Santana M, Seskar M, Tumer NE.

Nucleic Acids Res. 2004 Aug 10;32(14):4244-56.


Identification of amino acids critical for the cytotoxicity of Shiga toxin 1 and 2 in Saccharomyces cerevisiae.

Di R, Kyu E, Shete V, Saidasan H, Kahn PC, Tumer NE.

Toxicon. 2011 Mar 15;57(4):525-39. doi: 10.1016/j.toxicon.2010.12.006.


Active center cleft residues of pokeweed antiviral protein mediate its high-affinity binding to the ribosomal protein L3.

Rajamohan F, Ozer Z, Mao C, Uckun FM.

Biochemistry. 2001 Aug 7;40(31):9104-14.


Arginine residues on the opposite side of the active site stimulate the catalysis of ribosome depurination by ricin A chain by interacting with the P-protein stalk.

Li XP, Kahn PC, Kahn JN, Grela P, Tumer NE.

J Biol Chem. 2013 Oct 18;288(42):30270-84. doi: 10.1074/jbc.M113.510966.


A two-step binding model proposed for the electrostatic interactions of ricin a chain with ribosomes.

Li XP, Chiou JC, Remacha M, Ballesta JP, Tumer NE.

Biochemistry. 2009 May 12;48(18):3853-63. doi: 10.1021/bi802371h.


Pokeweed antiviral protein accesses ribosomes by binding to L3.

Hudak KA, Dinman JD, Tumer NE.

J Biol Chem. 1999 Feb 5;274(6):3859-64.

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