Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 113


A novel IFN regulatory factor 3-dependent pathway activated by trypanosomes triggers IFN-beta in macrophages and fibroblasts.

Chessler AD, Ferreira LR, Chang TH, Fitzgerald KA, Burleigh BA.

J Immunol. 2008 Dec 1;181(11):7917-24.


TLR-dependent induction of IFN-beta mediates host defense against Trypanosoma cruzi.

Koga R, Hamano S, Kuwata H, Atarashi K, Ogawa M, Hisaeda H, Yamamoto M, Akira S, Himeno K, Matsumoto M, Takeda K.

J Immunol. 2006 Nov 15;177(10):7059-66.


Long double-stranded RNA induces an antiviral response independent of IFN regulatory factor 3, IFN-beta promoter stimulator 1, and IFN.

DeWitte-Orr SJ, Mehta DR, Collins SE, Suthar MS, Gale M Jr, Mossman KL.

J Immunol. 2009 Nov 15;183(10):6545-53. doi: 10.4049/jimmunol.0900867. Epub 2009 Oct 28.


NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction.

Sasai M, Shingai M, Funami K, Yoneyama M, Fujita T, Matsumoto M, Seya T.

J Immunol. 2006 Dec 15;177(12):8676-83.


Unique O-methoxyethyl ribose-DNA chimeric oligonucleotide induces an atypical melanoma differentiation-associated gene 5-dependent induction of type I interferon response.

Burel SA, Machemer T, Ragone FL, Kato H, Cauntay P, Greenlee S, Salim A, Gaarde WA, Hung G, Peralta R, Freier SM, Henry SP.

J Pharmacol Exp Ther. 2012 Jul;342(1):150-62. doi: 10.1124/jpet.112.193789. Epub 2012 Apr 13.


The RNA-activated protein kinase enhances the induction of interferon-beta and apoptosis mediated by cytoplasmic RNA sensors.

McAllister CS, Samuel CE.

J Biol Chem. 2009 Jan 16;284(3):1644-51. doi: 10.1074/jbc.M807888200. Epub 2008 Nov 20.


DOK3 is required for IFN-β production by enabling TRAF3/TBK1 complex formation and IRF3 activation.

Kim SS, Lee KG, Chin CS, Ng SK, Pereira NA, Xu S, Lam KP.

J Immunol. 2014 Jul 15;193(2):840-8. doi: 10.4049/jimmunol.1301601. Epub 2014 Jun 13.


NFATc1 mediates Toll-like receptor-independent innate immune responses during Trypanosoma cruzi infection.

Kayama H, Koga R, Atarashi K, Okuyama M, Kimura T, Mak TW, Uematsu S, Akira S, Takayanagi H, Honda K, Yamamoto M, Takeda K.

PLoS Pathog. 2009 Jul;5(7):e1000514. doi: 10.1371/journal.ppat.1000514. Epub 2009 Jul 17.


IFN regulatory factor 3-dependent induction of type I IFNs by intracellular bacteria is mediated by a TLR- and Nod2-independent mechanism.

Stockinger S, Reutterer B, Schaljo B, Schellack C, Brunner S, Materna T, Yamamoto M, Akira S, Taniguchi T, Murray PJ, Müller M, Decker T.

J Immunol. 2004 Dec 15;173(12):7416-25.


IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling.

Lazear HM, Lancaster A, Wilkins C, Suthar MS, Huang A, Vick SC, Clepper L, Thackray L, Brassil MM, Virgin HW, Nikolich-Zugich J, Moses AV, Gale M Jr, Früh K, Diamond MS.

PLoS Pathog. 2013 Jan;9(1):e1003118. doi: 10.1371/journal.ppat.1003118. Epub 2013 Jan 3. Erratum in: PLoS Pathog. 2013 May;9(5). :10.1371/annotation/4de7ddfd-52df-4f87-8ca4-d48afe646ca8.


Phosphatidylinositol-3-kinase and Akt are required for RIG-I-mediated anti-viral signalling through cross-talk with IPS-1.

Yeon SH, Song MJ, Kang HR, Lee JY.

Immunology. 2015 Feb;144(2):312-20. doi: 10.1111/imm.12373.


Identification of TBK1 complexes required for the phosphorylation of IRF3 and the production of interferon β.

Bakshi S, Taylor J, Strickson S, McCartney T, Cohen P.

Biochem J. 2017 Mar 15;474(7):1163-1174. doi: 10.1042/BCJ20160992.


Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway.

Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, Sanjo H, Takeuchi O, Sugiyama M, Okabe M, Takeda K, Akira S.

Science. 2003 Aug 1;301(5633):640-3. Epub 2003 Jul 10.


Impaired innate immunity in Tlr4(-/-) mice but preserved CD8+ T cell responses against Trypanosoma cruzi in Tlr4-, Tlr2-, Tlr9- or Myd88-deficient mice.

Oliveira AC, de Alencar BC, Tzelepis F, Klezewsky W, da Silva RN, Neves FS, Cavalcanti GS, Boscardin S, Nunes MP, Santiago MF, Nóbrega A, Rodrigues MM, Bellio M.

PLoS Pathog. 2010 Apr 29;6(4):e1000870. doi: 10.1371/journal.ppat.1000870.


IFN-alpha regulates TLR-dependent gene expression of IFN-alpha, IFN-beta, IL-28, and IL-29.

Sirén J, Pirhonen J, Julkunen I, Matikainen S.

J Immunol. 2005 Feb 15;174(4):1932-7.


Modified vaccinia virus Ankara triggers type I IFN production in murine conventional dendritic cells via a cGAS/STING-mediated cytosolic DNA-sensing pathway.

Dai P, Wang W, Cao H, Avogadri F, Dai L, Drexler I, Joyce JA, Li XD, Chen Z, Merghoub T, Shuman S, Deng L.

PLoS Pathog. 2014 Apr 17;10(4):e1003989. doi: 10.1371/journal.ppat.1003989. eCollection 2014 Apr.


SARS-CoV nucleocapsid protein antagonizes IFN-β response by targeting initial step of IFN-β induction pathway, and its C-terminal region is critical for the antagonism.

Lu X, Pan J, Tao J, Guo D.

Virus Genes. 2011 Feb;42(1):37-45. doi: 10.1007/s11262-010-0544-x. Epub 2010 Oct 26.


PPM1A silences cytosolic RNA sensing and antiviral defense through direct dephosphorylation of MAVS and TBK1.

Xiang W, Zhang Q, Lin X, Wu S, Zhou Y, Meng F, Fan Y, Shen T, Xiao M, Xia Z, Zou J, Feng XH, Xu P.

Sci Adv. 2016 Jul 1;2(7):e1501889. doi: 10.1126/sciadv.1501889. eCollection 2016 Jul.


Induction of IFN-beta and the innate antiviral response in myeloid cells occurs through an IPS-1-dependent signal that does not require IRF-3 and IRF-7.

Daffis S, Suthar MS, Szretter KJ, Gale M Jr, Diamond MS.

PLoS Pathog. 2009 Oct;5(10):e1000607. doi: 10.1371/journal.ppat.1000607. Epub 2009 Oct 2.

Supplemental Content

Support Center