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Airway smooth muscle hyperplasia and hypertrophy correlate with glycogen synthase kinase-3(beta) phosphorylation in a mouse model of asthma.

Bentley JK, Deng H, Linn MJ, Lei J, Dokshin GA, Fingar DC, Bitar KN, Henderson WR Jr, Hershenson MB.

Am J Physiol Lung Cell Mol Physiol. 2009 Feb;296(2):L176-84. doi: 10.1152/ajplung.90376.2008. Epub 2008 Nov 14.


Inhibition of glycogen synthase kinase-3beta is sufficient for airway smooth muscle hypertrophy.

Deng H, Dokshin GA, Lei J, Goldsmith AM, Bitar KN, Fingar DC, Hershenson MB, Bentley JK.

J Biol Chem. 2008 Apr 11;283(15):10198-207. doi: 10.1074/jbc.M800624200. Epub 2008 Feb 5.


Akt activation induces hypertrophy without contractile phenotypic maturation in airway smooth muscle.

Ma L, Brown M, Kogut P, Serban K, Li X, McConville J, Chen B, Bentley JK, Hershenson MB, Dulin N, Solway J, Camoretti-Mercado B.

Am J Physiol Lung Cell Mol Physiol. 2011 May;300(5):L701-9. doi: 10.1152/ajplung.00119.2009. Epub 2011 Mar 4.


Mechanical stretch up-regulates microRNA-26a and induces human airway smooth muscle hypertrophy by suppressing glycogen synthase kinase-3β.

Mohamed JS, Lopez MA, Boriek AM.

J Biol Chem. 2010 Sep 17;285(38):29336-47. doi: 10.1074/jbc.M110.101147. Epub 2010 Jun 3.


Pulmonary artery smooth muscle hypertrophy: roles of glycogen synthase kinase-3beta and p70 ribosomal S6 kinase.

Deng H, Hershenson MB, Lei J, Anyanwu AC, Pinsky DJ, Bentley JK.

Am J Physiol Lung Cell Mol Physiol. 2010 Jun;298(6):L793-803. doi: 10.1152/ajplung.00108.2009. Epub 2010 Feb 26.


[Effects of budesonide on airway inflammation and airway remodeling in the ovalbumin sensitized and challenged mice].

Shen HH, Wang SB.

Zhonghua Jie He He Hu Xi Za Zhi. 2005 Mar;28(3):154-9. Chinese.


Hypertrophic airway smooth muscle mass correlates with increased airway responsiveness in a murine model of asthma.

Plant PJ, North ML, Ward A, Ward M, Khanna N, Correa J, Scott JA, Batt J.

Am J Respir Cell Mol Biol. 2012 Apr;46(4):532-40. doi: 10.1165/rcmb.2011-0293OC. Epub 2011 Nov 22.


Glycogen synthase kinase-3β/β-catenin signaling regulates neonatal lung mesenchymal stromal cell myofibroblastic differentiation.

Popova AP, Bentley JK, Anyanwu AC, Richardson MN, Linn MJ, Lei J, Wong EJ, Goldsmith AM, Pryhuber GS, Hershenson MB.

Am J Physiol Lung Cell Mol Physiol. 2012 Sep;303(5):L439-48. doi: 10.1152/ajplung.00408.2011. Epub 2012 Jul 6.


Potential Role of Glycogen Synthase Kinase-3β in Regulation of Myocardin Activity in Human Vascular Smooth Muscle Cells.

Zhou YX, Shi Z, Singh P, Yin H, Yu YN, Li L, Walsh MP, Gui Y, Zheng XL.

J Cell Physiol. 2016 Feb;231(2):393-402. doi: 10.1002/jcp.25084.


Transforming growth factor-β-induced differentiation of airway smooth muscle cells is inhibited by fibroblast growth factor-2.

Schuliga M, Javeed A, Harris T, Xia Y, Qin C, Wang Z, Zhang X, Lee PV, Camoretti-Mercado B, Stewart AG.

Am J Respir Cell Mol Biol. 2013 Mar;48(3):346-53. doi: 10.1165/rcmb.2012-0151OC. Epub 2012 Dec 13.


Smooth muscle CaMKIIδ promotes allergen-induced airway hyperresponsiveness and inflammation.

Spinelli AM, Liu Y, Sun LY, González-Cobos JC, Backs J, Trebak M, Singer HA.

Pflugers Arch. 2015 Dec;467(12):2541-54. doi: 10.1007/s00424-015-1713-5. Epub 2015 Jun 20.


The presence of LPS in OVA inhalations affects airway inflammation and AHR but not remodeling in a rodent model of asthma.

Tsuchiya K, Siddiqui S, Risse PA, Hirota N, Martin JG.

Am J Physiol Lung Cell Mol Physiol. 2012 Jul 1;303(1):L54-63. doi: 10.1152/ajplung.00208.2011. Epub 2012 Apr 20.


Cooperative regulation of GSK-3 by muscarinic and PDGF receptors is associated with airway myocyte proliferation.

Gosens R, Dueck G, Rector E, Nunes RO, Gerthoffer WT, Unruh H, Zaagsma J, Meurs H, Halayko AJ.

Am J Physiol Lung Cell Mol Physiol. 2007 Nov;293(5):L1348-58. Epub 2007 Sep 14.


ISO-1, a macrophage migration inhibitory factor antagonist, inhibits airway remodeling in a murine model of chronic asthma.

Chen PF, Luo YL, Wang W, Wang JX, Lai WY, Hu SM, Cheng KF, Al-Abed Y.

Mol Med. 2010 Sep-Oct;16(9-10):400-8. doi: 10.2119/molmed.2009.00128. Epub 2010 May 14.


The aurora kinase A regulates GSK-3beta in gastric cancer cells.

Dar AA, Belkhiri A, El-Rifai W.

Oncogene. 2009 Feb 12;28(6):866-75. doi: 10.1038/onc.2008.434. Epub 2008 Dec 8.


Glycogen synthase kinase-3beta inhibition attenuates asthma in mice.

Bao Z, Lim S, Liao W, Lin Y, Thiemermann C, Leung BP, Wong WS.

Am J Respir Crit Care Med. 2007 Sep 1;176(5):431-8. Epub 2007 Jun 7.


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