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Items: 1 to 20 of 192

1.

Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4.

Cortellino S, Wang C, Wang B, Bassi MR, Caretti E, Champeval D, Calmont A, Jarnik M, Burch J, Zaret KS, Larue L, Bellacosa A.

Dev Biol. 2009 Jan 1;325(1):225-37. doi: 10.1016/j.ydbio.2008.10.020. Epub 2008 Oct 29.

2.

Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components.

Qin J, Lin Y, Norman RX, Ko HW, Eggenschwiler JT.

Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1456-61. doi: 10.1073/pnas.1011410108. Epub 2011 Jan 5.

3.

G-protein-coupled receptors and localized signaling in the primary cilium during ventral neural tube patterning.

Hwang SH, Mukhopadhyay S.

Birth Defects Res A Clin Mol Teratol. 2015 Jan;103(1):12-9. doi: 10.1002/bdra.23267. Epub 2014 Jun 11.

PMID:
24917297
4.

The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking.

Liem KF Jr, Ashe A, He M, Satir P, Moran J, Beier D, Wicking C, Anderson KV.

J Cell Biol. 2012 Jun 11;197(6):789-800. doi: 10.1083/jcb.201110049.

5.

The graded response to Sonic Hedgehog depends on cilia architecture.

Caspary T, Larkins CE, Anderson KV.

Dev Cell. 2007 May;12(5):767-78.

6.

Intraflagellar transport protein 172 is essential for primary cilia formation and plays a vital role in patterning the mammalian brain.

Gorivodsky M, Mukhopadhyay M, Wilsch-Braeuninger M, Phillips M, Teufel A, Kim C, Malik N, Huttner W, Westphal H.

Dev Biol. 2009 Jan 1;325(1):24-32. doi: 10.1016/j.ydbio.2008.09.019. Epub 2008 Sep 26.

7.
8.

Cluap1 localizes preferentially to the base and tip of cilia and is required for ciliogenesis in the mouse embryo.

Botilde Y, Yoshiba S, Shinohara K, Hasegawa T, Nishimura H, Shiratori H, Hamada H.

Dev Biol. 2013 Sep 1;381(1):203-12. doi: 10.1016/j.ydbio.2013.05.024. Epub 2013 Jun 4.

9.

Forward genetics uncovers Transmembrane protein 107 as a novel factor required for ciliogenesis and Sonic hedgehog signaling.

Christopher KJ, Wang B, Kong Y, Weatherbee SD.

Dev Biol. 2012 Aug 15;368(2):382-92. doi: 10.1016/j.ydbio.2012.06.008. Epub 2012 Jun 12.

10.

The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling.

Mukhopadhyay S, Wen X, Ratti N, Loktev A, Rangell L, Scales SJ, Jackson PK.

Cell. 2013 Jan 17;152(1-2):210-23. doi: 10.1016/j.cell.2012.12.026.

11.

Primary cilia are critical for Sonic hedgehog-mediated dopaminergic neurogenesis in the embryonic midbrain.

Gazea M, Tasouri E, Tolve M, Bosch V, Kabanova A, Gojak C, Kurtulmus B, Novikov O, Spatz J, Pereira G, Hübner W, Brodski C, Tucker KL, Blaess S.

Dev Biol. 2016 Jan 1;409(1):55-71. doi: 10.1016/j.ydbio.2015.10.033. Epub 2015 Nov 2.

12.

Disruption of Mks1 localization to the mother centriole causes cilia defects and developmental malformations in Meckel-Gruber syndrome.

Cui C, Chatterjee B, Francis D, Yu Q, SanAgustin JT, Francis R, Tansey T, Henry C, Wang B, Lemley B, Pazour GJ, Lo CW.

Dis Model Mech. 2011 Jan;4(1):43-56. doi: 10.1242/dmm.006262. Epub 2010 Nov 2.

13.

Intestinal cell kinase, a protein associated with endocrine-cerebro-osteodysplasia syndrome, is a key regulator of cilia length and Hedgehog signaling.

Moon H, Song J, Shin JO, Lee H, Kim HK, Eggenschwiller JT, Bok J, Ko HW.

Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8541-6. doi: 10.1073/pnas.1323161111. Epub 2014 May 22.

14.

Intraflagellar transport, cilia, and mammalian Hedgehog signaling: analysis in mouse embryonic fibroblasts.

Ocbina PJ, Anderson KV.

Dev Dyn. 2008 Aug;237(8):2030-8. doi: 10.1002/dvdy.21551.

15.

A novel murine allele of Intraflagellar Transport Protein 172 causes a syndrome including VACTERL-like features with hydrocephalus.

Friedland-Little JM, Hoffmann AD, Ocbina PJ, Peterson MA, Bosman JD, Chen Y, Cheng SY, Anderson KV, Moskowitz IP.

Hum Mol Genet. 2011 Oct 1;20(19):3725-37. doi: 10.1093/hmg/ddr241. Epub 2011 Jun 8.

16.

IFT25 links the signal-dependent movement of Hedgehog components to intraflagellar transport.

Keady BT, Samtani R, Tobita K, Tsuchya M, San Agustin JT, Follit JA, Jonassen JA, Subramanian R, Lo CW, Pazour GJ.

Dev Cell. 2012 May 15;22(5):940-51. doi: 10.1016/j.devcel.2012.04.009.

17.

Intraflagellar transport 27 is essential for hedgehog signaling but dispensable for ciliogenesis during hair follicle morphogenesis.

Yang N, Li L, Eguether T, Sundberg JP, Pazour GJ, Chen J.

Development. 2015 Jun 15;142(12):2194-202. doi: 10.1242/dev.115261. Epub 2015 May 28. Erratum in: Development. 2015 Aug 15;142(16):2860.

18.

Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis.

Wang C, Low WC, Liu A, Wang B.

J Biol Chem. 2013 Oct 11;288(41):29518-29. doi: 10.1074/jbc.M113.492066. Epub 2013 Aug 16.

19.

Analysis of hedgehog signaling in mouse intraflagellar transport mutants.

Ko HW, Liu A, Eggenschwiler JT.

Methods Cell Biol. 2009;93:347-69. doi: 10.1016/S0091-679X(08)93017-X. Epub 2009 Dec 4.

20.

Arl13b regulates ciliogenesis and the dynamic localization of Shh signaling proteins.

Larkins CE, Aviles GD, East MP, Kahn RA, Caspary T.

Mol Biol Cell. 2011 Dec;22(23):4694-703. doi: 10.1091/mbc.E10-12-0994. Epub 2011 Oct 5.

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