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Items: 1 to 20 of 84

1.

Differences in paclitaxel and docetaxel interactions with tubulin detected by mutagenesis of yeast tubulin.

Winefield RD, Entwistle RA, Foland TB, Lushington GH, Himes RH.

ChemMedChem. 2008 Dec;3(12):1844-7. doi: 10.1002/cmdc.200800288. No abstract available.

2.

The paclitaxel site in tubulin probed by site-directed mutagenesis of Saccharomyces cerevisiae beta-tubulin.

Entwistle RA, Winefield RD, Foland TB, Lushington GH, Himes RH.

FEBS Lett. 2008 Jul 9;582(16):2467-70. doi: 10.1016/j.febslet.2008.06.013. Epub 2008 Jun 18.

3.

Insights into the interaction of discodermolide and docetaxel with tubulin. Mapping the binding sites of microtubule-stabilizing agents by using an integrated NMR and computational approach.

Canales A, Rodríguez-Salarichs J, Trigili C, Nieto L, Coderch C, Andreu JM, Paterson I, Jiménez-Barbero J, Díaz JF.

ACS Chem Biol. 2011 Aug 19;6(8):789-99. doi: 10.1021/cb200099u. Epub 2011 May 13.

4.

Elucidating the mechanism of action of the clinically approved taxanes: a comprehensive comparison of local and allosteric effects.

Churchill CD, Klobukowski M, Tuszynski JA.

Chem Biol Drug Des. 2015 Nov;86(5):1253-66. doi: 10.1111/cbdd.12595. Epub 2015 Jul 14.

PMID:
26032329
5.

Understanding tubulin/microtubule-taxane interactions: a quantitative structure-activity relationship study.

Hansch C, Verma RP.

Mol Pharm. 2008 Jan-Feb;5(1):151-61. doi: 10.1021/mp700119e. Epub 2008 Jan 3.

PMID:
18171015
6.

Evaluation of novel epothilone analogues by means of a common pharmacophore and a QSAR pseudoreceptor model for taxanes and epothilones.

Forli S, Manetti F, Altmann KH, Botta M.

ChemMedChem. 2010 Jan;5(1):35-40. doi: 10.1002/cmdc.200900303. No abstract available.

PMID:
19904799
7.

Differentiating between models of epothilone binding to microtubules using tubulin mutagenesis, cytotoxicity, and molecular modeling.

Entwistle RA, Rizk RS, Cheng DM, Lushington GH, Himes RH, Gupta ML Jr.

ChemMedChem. 2012 Sep;7(9):1580-6. doi: 10.1002/cmdc.201200286. Epub 2012 Jul 16.

8.

Tubulin-targeting agents.

Hait WN, Rubin E, Goodin S.

Cancer Chemother Biol Response Modif. 2003;21:41-67. Review. No abstract available.

PMID:
15338740
9.

Molecular mechanism of action of microtubule-stabilizing anticancer agents.

Prota AE, Bargsten K, Zurwerra D, Field JJ, Díaz JF, Altmann KH, Steinmetz MO.

Science. 2013 Feb 1;339(6119):587-90. doi: 10.1126/science.1230582. Epub 2013 Jan 3.

10.

Syntheses and bioactivities of macrocyclic paclitaxel bis-lactones.

Liu C, Schilling JK, Ravindra R, Bane S, Kingston DG.

Bioorg Med Chem. 2004 Dec 1;12(23):6147-61.

PMID:
15519159
11.

Novel C2-C3' N-peptide linked macrocyclic taxoids. Part 1: Synthesis and biological activities of docetaxel analogues with a peptide side chain at C3'.

Larroque AL, Dubois J, Thoret S, Aubert G, Guénard D, Guéritte F.

Bioorg Med Chem Lett. 2005 Nov 1;15(21):4722-6.

PMID:
16165352
12.

Preclinical pharmacologic evaluation of MST-997, an orally active taxane with superior in vitro and in vivo efficacy in paclitaxel- and docetaxel-resistant tumor models.

Sampath D, Greenberger LM, Beyer C, Hari M, Liu H, Baxter M, Yang S, Rios C, Discafani C.

Clin Cancer Res. 2006 Jun 1;12(11 Pt 1):3459-69.

13.

Dissecting paclitaxel-microtubule association: quantitative assessment of the 2'-OH group.

Sharma S, Lagisetti C, Poliks B, Coates RM, Kingston DG, Bane S.

Biochemistry. 2013 Apr 2;52(13):2328-36. doi: 10.1021/bi400014t. Epub 2013 Mar 19.

14.
15.

CoMFA, HQSAR and molecular docking studies of butitaxel analogues with beta-tubulin.

Cunningham SL, Cunningham AR, Day BW.

J Mol Model. 2005 Feb;11(1):48-54. Epub 2004 Dec 23.

PMID:
15616834
16.

Biological evaluation of new antitumor taxoids: alteration of substitution at the C-7 and C-10 of docetaxel.

Li C, Qiu Y, Li X, Liu N, Yao Z.

Bioorg Med Chem Lett. 2014 Feb 1;24(3):855-9. doi: 10.1016/j.bmcl.2013.12.083. Epub 2013 Dec 27.

PMID:
24405702
17.

Synthesis of novel macrocyclic docetaxel analogues. Influence of their macrocyclic ring size on tubulin activity.

Querolle O, Dubois J, Thoret S, Roussi F, Montiel-Smith S, Guéritte F, Guénard D.

J Med Chem. 2003 Aug 14;46(17):3623-30.

PMID:
12904066
18.

Synthesis, biological evaluations, and tubulin binding poses of C-2alpha sulfur linked taxol analogues.

Wang L, Alcaraz AA, Matesanz R, Yang CG, Barasoain I, Díaz JF, Li YZ, Snyder JP, Fang WS.

Bioorg Med Chem Lett. 2007 Jun 1;17(11):3191-4. Epub 2007 Mar 14.

PMID:
17395465
19.

Dual-functional abeo-taxane derivatives destabilizing microtubule equilibrium and inhibiting NF-κB activation.

Zhao Y, Su J, Goto M, Morris-Natschke SL, Li Y, Zhao QS, Yao ZJ, Lee KH.

J Med Chem. 2013 Jun 13;56(11):4749-57. doi: 10.1021/jm400479p. Epub 2013 May 31.

20.

Cyclostreptin (FR182877), an antitumor tubulin-polymerizing agent deficient in enhancing tubulin assembly despite its high affinity for the taxoid site.

Edler MC, Buey RM, Gussio R, Marcus AI, Vanderwal CD, Sorensen EJ, Díaz JF, Giannakakou P, Hamel E.

Biochemistry. 2005 Aug 30;44(34):11525-38. Erratum in: Biochemistry. 2006 May 9;45(18):5932.

PMID:
16114889

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