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Items: 1 to 20 of 165

1.

Novel 3,3-disubstituted pyrrolidines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors.

Bannwart LM, Carter DS, Cai HY, Choy JC, Greenhouse R, Jaime-Figueroa S, Iyer PS, Lin CJ, Lee EK, Lucas MC, Lynch SM, Madera AM, Moore A, Ozboya K, Raptova L, Roetz R, Schoenfeld RC, Stein KA, Steiner S, Villa M, Weikert RJ, Zhai Y.

Bioorg Med Chem Lett. 2008 Dec 1;18(23):6062-6. doi: 10.1016/j.bmcl.2008.10.025. Epub 2008 Oct 11.

PMID:
18954985
2.

Design, synthesis, and biological evaluation of new monoamine reuptake inhibitors with potential therapeutic utility in depression and pain.

Lucas MC, Weikert RJ, Carter DS, Cai HY, Greenhouse R, Iyer PS, Lin CJ, Lee EK, Madera AM, Moore A, Ozboya K, Schoenfeld RC, Steiner S, Zhai Y, Lynch SM.

Bioorg Med Chem Lett. 2010 Sep 15;20(18):5559-66. doi: 10.1016/j.bmcl.2010.07.020. Epub 2010 Aug 4.

PMID:
20691589
3.

Antidepressant-like pharmacological profile of a novel triple reuptake inhibitor, (1S,2S)-3-(methylamino)-2-(naphthalen-2-yl)-1-phenylpropan-1-ol (PRC200-SS).

Liang Y, Shaw AM, Boules M, Briody S, Robinson J, Oliveros A, Blazar E, Williams K, Zhang Y, Carlier PR, Richelson E.

J Pharmacol Exp Ther. 2008 Nov;327(2):573-83. doi: 10.1124/jpet.108.143610. Epub 2008 Aug 8.

4.

Discovery of N-methyl-1-(1-phenylcyclohexyl)methanamine, a novel triple serotonin, norepinephrine, and dopamine reuptake inhibitor.

Shao L, Hewitt MC, Wang F, Malcolm SC, Ma J, Campbell JE, Campbell UC, Engel SR, Spicer NA, Hardy LW, Schreiber R, Spear KL, Varney MA.

Bioorg Med Chem Lett. 2011 Mar 1;21(5):1438-41. doi: 10.1016/j.bmcl.2011.01.016. Epub 2011 Jan 12.

PMID:
21310609
5.

Design, synthesis, and biological activities of 1-aryl-1,4-diazepan-2-one derivatives as novel triple reuptake inhibitors.

Honda E, Ishichi Y, Kimura E, Yoshikawa M, Kanzaki N, Nakagawa H, Terao Y, Suzuki A, Kawai T, Arakawa Y, Ohta H, Terauchi J.

Bioorg Med Chem Lett. 2014 Aug 15;24(16):3898-902. doi: 10.1016/j.bmcl.2014.06.046. Epub 2014 Jun 24.

PMID:
25017029
6.

Synthesis and pharmacological evaluation of 3-aryl-3-azolylpropan-1-amines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors.

Lee KH, Park CE, Min KH, Shin YJ, Chung CM, Kim HH, Yoon HJ, Won-Kim, Ryu EJ, Shin YJ, Nam HS, Cho JW, Lee HY.

Bioorg Med Chem Lett. 2010 Sep 15;20(18):5567-71. doi: 10.1016/j.bmcl.2010.07.021. Epub 2010 Aug 17.

PMID:
20724153
7.

D-161, a novel pyran-based triple monoamine transporter blocker: behavioral pharmacological evidence for antidepressant-like action.

Dutta AK, Ghosh B, Biswas S, Reith ME.

Eur J Pharmacol. 2008 Jul 28;589(1-3):73-9. doi: 10.1016/j.ejphar.2008.05.008. Epub 2008 May 20.

PMID:
18561912
8.

N-[(3S)-Pyrrolidin-3-yl]benzamides as novel dual serotonin and noradrenaline reuptake inhibitors: impact of small structural modifications on P-gp recognition and CNS penetration.

Wakenhut F, Allan GA, Fish PV, Fray MJ, Harrison AC, McCoy R, Phillips SC, Ryckmans T, Stobie A, Westbrook D, Westbrook SL, Whitlock GA.

Bioorg Med Chem Lett. 2009 Sep 1;19(17):5078-81. doi: 10.1016/j.bmcl.2009.07.049. Epub 2009 Jul 31. Erratum in: Bioorg Med Chem Lett. 2010 Jan 15;20(2):772. Ryckmans, Thomas [added].

PMID:
19647430
9.

4-Piperidines and 3-pyrrolidines as dual serotonin and noradrenaline reuptake inhibitors: design, synthesis and structure-activity relationships.

Fish PV, Andrews MD, Jonathan Fray M, Stobie A, Wakenhut F, Whitlock GA.

Bioorg Med Chem Lett. 2009 May 15;19(10):2829-34. doi: 10.1016/j.bmcl.2009.03.090. Epub 2009 Mar 26.

PMID:
19359175
10.

Antidepressant-like effects of novel triple reuptake inhibitors, PRC025 and PRC050.

Shaw AM, Boules M, Zhang Y, Williams K, Robinson J, Carlier PR, Richelson E.

Eur J Pharmacol. 2007 Jan 19;555(1):30-6. Epub 2006 Oct 17.

PMID:
17109850
11.

N-Benzyl-N-(pyrrolidin-3-yl)carboxamides as a new class of selective dual serotonin/noradrenaline reuptake inhibitors.

Wakenhut F, Fish PV, Fray MJ, Gurrell I, Mills JE, Stobie A, Whitlock GA.

Bioorg Med Chem Lett. 2008 Aug 1;18(15):4308-11. doi: 10.1016/j.bmcl.2008.06.078. Epub 2008 Jun 28.

PMID:
18625557
12.

Discovery of N-methyl-1-(1-phenylcyclohexyl)ethanamine, a novel triple serotonin, norepinephrine and dopamine reuptake inhibitor.

Shao L, Hewitt MC, Wang F, Malcolm SC, Ma J, Campbell JE, Campbell UC, Engel SR, Spicer NA, Hardy LW, Schreiber R, Spear KL, Varney MA.

Bioorg Med Chem Lett. 2011 Mar 1;21(5):1434-7. doi: 10.1016/j.bmcl.2011.01.019. Epub 2011 Jan 12.

PMID:
21310612
13.

Pharmacophore-based discovery of 3,4-disubstituted pyrrolidines as a novel class of monoamine transporter inhibitors.

Enyedy IJ, Zaman WA, Sakamuri S, Kozikowski AP, Johnson KM, Wang S.

Bioorg Med Chem Lett. 2001 May 7;11(9):1113-8.

PMID:
11354356
14.

2-Substituted N-aryl piperazines as novel triple reuptake inhibitors for the treatment of depression.

Carter DS, Cai HY, Lee EK, Iyer PS, Lucas MC, Roetz R, Schoenfeld RC, Weikert RJ.

Bioorg Med Chem Lett. 2010 Jul 1;20(13):3941-5. doi: 10.1016/j.bmcl.2010.05.008. Epub 2010 May 10.

PMID:
20570146
15.

Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors.

Shao L, Wang F, Malcolm SC, Ma J, Hewitt MC, Campbell UC, Bush LR, Spicer NA, Engel SR, Saraswat LD, Hardy LW, Koch P, Schreiber R, Spear KL, Varney MA.

Bioorg Med Chem. 2011 Jan 1;19(1):663-76. doi: 10.1016/j.bmc.2010.10.034. Epub 2010 Oct 21.

PMID:
21093273
16.

N-Benzyl-N-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-amines as selective dual serotonin/noradrenaline reuptake inhibitors.

Fish PV, Fray MJ, Stobie A, Wakenhut F, Whitlock GA.

Bioorg Med Chem Lett. 2007 Apr 1;17(7):2022-5. Epub 2007 Jan 19.

PMID:
17267217
17.

A novel class of 3-(phenoxy-phenyl-methyl)-pyrrolidines as potent and balanced norepinephrine and serotonin reuptake inhibitors: synthesis and structure-activity relationships.

Van Orden LJ, Van Dyke PM, Saito DR, Church TJ, Chang R, Smith JA, Martin WJ, Jaw-Tsai S, Stangeland EL.

Bioorg Med Chem Lett. 2013 Mar 1;23(5):1456-61. doi: 10.1016/j.bmcl.2012.12.061. Epub 2012 Dec 22.

PMID:
23347683
18.

Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction.

Carroll FI, Blough BE, Abraham P, Mills AC, Holleman JA, Wolckenhauer SA, Decker AM, Landavazo A, McElroy KT, Navarro HA, Gatch MB, Forster MJ.

J Med Chem. 2009 Nov 12;52(21):6768-81. doi: 10.1021/jm901189z.

PMID:
19821577
19.
20.

Synthesis and biological evaluation of novel 3,4-diaryl lactam derivatives as triple reuptake inhibitors.

Park JE, Song C, Choi K, Sim T, Moon B, Roh EJ.

Bioorg Med Chem Lett. 2013 Oct 15;23(20):5515-8. doi: 10.1016/j.bmcl.2013.08.062. Epub 2013 Aug 26.

PMID:
24012181

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