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Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA.

Heo I, Joo C, Cho J, Ha M, Han J, Kim VN.

Mol Cell. 2008 Oct 24;32(2):276-84. doi: 10.1016/j.molcel.2008.09.014.


TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation.

Heo I, Joo C, Kim YK, Ha M, Yoon MJ, Cho J, Yeom KH, Han J, Kim VN.

Cell. 2009 Aug 21;138(4):696-708. doi: 10.1016/j.cell.2009.08.002.


A role of uridylation pathway for blockade of let-7 microRNA biogenesis by Lin28B.

Suzuki HI, Katsura A, Miyazono K.

Cancer Sci. 2015 Sep;106(9):1174-81. doi: 10.1111/cas.12721. Epub 2015 Jul 14.


Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28.

Piskounova E, Viswanathan SR, Janas M, LaPierre RJ, Daley GQ, Sliz P, Gregory RI.

J Biol Chem. 2008 Aug 1;283(31):21310-4. doi: 10.1074/jbc.C800108200. Epub 2008 Jun 12.


Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs.

Heo I, Ha M, Lim J, Yoon MJ, Park JE, Kwon SC, Chang H, Kim VN.

Cell. 2012 Oct 26;151(3):521-32. doi: 10.1016/j.cell.2012.09.022. Epub 2012 Oct 11.


The nuclear RNase III Drosha initiates microRNA processing.

Lee Y, Ahn C, Han J, Choi H, Kim J, Yim J, Lee J, Provost P, RĂ„dmark O, Kim S, Kim VN.

Nature. 2003 Sep 25;425(6956):415-9.


A mirror of two faces: Lin28 as a master regulator of both miRNA and mRNA.

Huang Y.

Wiley Interdiscip Rev RNA. 2012 Jul-Aug;3(4):483-94. doi: 10.1002/wrna.1112. Epub 2012 Mar 29. Review.


Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells.

Hagan JP, Piskounova E, Gregory RI.

Nat Struct Mol Biol. 2009 Oct;16(10):1021-5. doi: 10.1038/nsmb.1676. Epub 2009 Aug 27.


A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment.

Rybak A, Fuchs H, Smirnova L, Brandt C, Pohl EE, Nitsch R, Wulczyn FG.

Nat Cell Biol. 2008 Aug;10(8):987-93. doi: 10.1038/ncb1759. Epub 2008 Jul 6.


Functional anatomy of the Drosophila microRNA-generating enzyme.

Ye X, Paroo Z, Liu Q.

J Biol Chem. 2007 Sep 28;282(39):28373-8. Epub 2007 Jul 31.


Dicer-1 and R3D1-L catalyze microRNA maturation in Drosophila.

Jiang F, Ye X, Liu X, Fincher L, McKearin D, Liu Q.

Genes Dev. 2005 Jul 15;19(14):1674-9. Epub 2005 Jun 28.


Normal microRNA maturation and germ-line stem cell maintenance requires Loquacious, a double-stranded RNA-binding domain protein.

Förstemann K, Tomari Y, Du T, Vagin VV, Denli AM, Bratu DP, Klattenhoff C, Theurkauf WE, Zamore PD.

PLoS Biol. 2005 Jul;3(7):e236. Epub 2005 May 24.


Short loop-targeting oligoribonucleotides antagonize Lin28 and enable pre-let-7 processing and suppression of cell growth in let-7-deficient cancer cells.

Roos M, Rebhan MA, Lucic M, Pavlicek D, Pradere U, Towbin H, Civenni G, Catapano CV, Hall J.

Nucleic Acids Res. 2015 Jan;43(2):e9. doi: 10.1093/nar/gku1090. Epub 2014 Nov 6.


Human RISC couples microRNA biogenesis and posttranscriptional gene silencing.

Gregory RI, Chendrimada TP, Cooch N, Shiekhattar R.

Cell. 2005 Nov 18;123(4):631-40. Epub 2005 Nov 3.


Posttranscriptional regulation of microRNA biogenesis in animals.

Siomi H, Siomi MC.

Mol Cell. 2010 May 14;38(3):323-32. doi: 10.1016/j.molcel.2010.03.013. Review.


A LIN28-dependent structural change in pre-let-7g directly inhibits dicer processing.

Lightfoot HL, Bugaut A, Armisen J, Lehrbach NJ, Miska EA, Balasubramanian S.

Biochemistry. 2011 Sep 6;50(35):7514-21. doi: 10.1021/bi200851d. Epub 2011 Aug 11.


LIN28 alters cell fate succession and acts independently of the let-7 microRNA during neurogliogenesis in vitro.

Balzer E, Heine C, Jiang Q, Lee VM, Moss EG.

Development. 2010 Mar;137(6):891-900. doi: 10.1242/dev.042895.


Lin28a is dormant, functional, and dispensable during mouse oocyte-to-embryo transition.

Flemr M, Moravec M, Libova V, Sedlacek R, Svoboda P.

Biol Reprod. 2014 Jun;90(6):131. doi: 10.1095/biolreprod.114.118703. Epub 2014 May 14.


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