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Items: 1 to 20 of 142


Differential dependence of hypoxia-inducible factors 1 alpha and 2 alpha on mTORC1 and mTORC2.

Toschi A, Lee E, Gadir N, Ohh M, Foster DA.

J Biol Chem. 2008 Dec 12;283(50):34495-9. doi: 10.1074/jbc.C800170200. Epub 2008 Oct 22.


Regulation of androgen receptor transcriptional activity by rapamycin in prostate cancer cell proliferation and survival.

Wang Y, Mikhailova M, Bose S, Pan CX, deVere White RW, Ghosh PM.

Oncogene. 2008 Nov 27;27(56):7106-17. doi: 10.1038/onc.2008.318. Epub 2008 Sep 8.


Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin.

Toschi A, Lee E, Xu L, Garcia A, Gadir N, Foster DA.

Mol Cell Biol. 2009 Mar;29(6):1411-20. doi: 10.1128/MCB.00782-08. Epub 2008 Dec 29.


Hypoxia-induced endothelial proliferation requires both mTORC1 and mTORC2.

Li W, Petrimpol M, Molle KD, Hall MN, Battegay EJ, Humar R.

Circ Res. 2007 Jan 5;100(1):79-87. Epub 2006 Nov 16.


mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling.

Julien LA, Carriere A, Moreau J, Roux PP.

Mol Cell Biol. 2010 Feb;30(4):908-21. doi: 10.1128/MCB.00601-09. Epub 2009 Dec 7.


PI3K-mTORC2 but not PI3K-mTORC1 regulates transcription of HIF2A/EPAS1 and vascularization in neuroblastoma.

Mohlin S, Hamidian A, von Stedingk K, Bridges E, Wigerup C, Bexell D, Påhlman S.

Cancer Res. 2015 Nov 1;75(21):4617-28. doi: 10.1158/0008-5472.CAN-15-0708. Epub 2015 Oct 2.


PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling.

Woo SY, Kim DH, Jun CB, Kim YM, Haar EV, Lee SI, Hegg JW, Bandhakavi S, Griffin TJ, Kim DH.

J Biol Chem. 2007 Aug 31;282(35):25604-12. Epub 2007 Jun 28.


Rapamycin-Induced Hypoxia Inducible Factor 2A Is Essential for Chondrogenic Differentiation of Amniotic Fluid Stem Cells.

Preitschopf A, Schörghofer D, Kinslechner K, Schütz B, Zwickl H, Rosner M, Joó JG, Nehrer S, Hengstschläger M, Mikula M.

Stem Cells Transl Med. 2016 May;5(5):580-90. doi: 10.5966/sctm.2015-0262. Epub 2016 Mar 29.


Prognostic impact of hypoxia-inducible factors 1alpha and 2alpha in colorectal cancer patients: correlation with tumor angiogenesis and cyclooxygenase-2 expression.

Yoshimura H, Dhar DK, Kohno H, Kubota H, Fujii T, Ueda S, Kinugasa S, Tachibana M, Nagasue N.

Clin Cancer Res. 2004 Dec 15;10(24):8554-60.


mTORC1 and mTORC2 regulate insulin secretion through Akt in INS-1 cells.

Le Bacquer O, Queniat G, Gmyr V, Kerr-Conte J, Lefebvre B, Pattou F.

J Endocrinol. 2013 Jan 2;216(1):21-9. doi: 10.1530/JOE-12-0351. Print 2013 Jan.


Endothelial Cell mTOR Complex-2 Regulates Sprouting Angiogenesis.

Farhan MA, Carmine-Simmen K, Lewis JD, Moore RB, Murray AG.

PLoS One. 2015 Aug 21;10(8):e0135245. doi: 10.1371/journal.pone.0135245. eCollection 2015.


Stabilization of HIF-2α through redox regulation of mTORC2 activation and initiation of mRNA translation.

Nayak BK, Feliers D, Sudarshan S, Friedrichs WE, Day RT, New DD, Fitzgerald JP, Eid A, Denapoli T, Parekh DJ, Gorin Y, Block K.

Oncogene. 2013 Jun 27;32(26):3147-55. doi: 10.1038/onc.2012.333. Epub 2012 Aug 6.


STAT3 or USF2 contributes to HIF target gene specificity.

Pawlus MR, Wang L, Murakami A, Dai G, Hu CJ.

PLoS One. 2013 Aug 21;8(8):e72358. doi: 10.1371/journal.pone.0072358. eCollection 2013.


Rapamycin regulates the phosphorylation of rictor.

Akcakanat A, Singh G, Hung MC, Meric-Bernstam F.

Biochem Biophys Res Commun. 2007 Oct 19;362(2):330-3. Epub 2007 Aug 8.


Targeting of mTORC2 may have advantages over selective targeting of mTORC1 in the treatment of malignant pheochromocytoma.

Zhang X, Wang X, Xu T, Zhong S, Shen Z.

Tumour Biol. 2015 Jul;36(7):5273-81. doi: 10.1007/s13277-015-3187-7. Epub 2015 Feb 11.


Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2.

Luo Y, Liu L, Wu Y, Singh K, Su B, Zhang N, Liu X, Shen Y, Huang S.

Oncotarget. 2015 Feb 28;6(6):4286-98.


Distinct signaling mechanisms of mTORC1 and mTORC2 in glioblastoma multiforme: a tale of two complexes.

Jhanwar-Uniyal M, Gillick JL, Neil J, Tobias M, Thwing ZE, Murali R.

Adv Biol Regul. 2015 Jan;57:64-74. doi: 10.1016/j.jbior.2014.09.004. Epub 2014 Sep 18.


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